|Tested species reactivity||Dog, Horse, Cat|
|Host / Isotype||Mouse / IgG1|
|Immunogen||The details of the immunogen for this antibody are not currently available.|
|Storage buffer||PBS with 1% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C, store in dark, DO NOT FREEZE!|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Neat|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-16609 should not be used with MA5-16605 (mouse anti-canine CD3), in dual color flow cytometry, due to non-specific interactions between the two reagents. For FACS analysis, use 10ul of the suggested working dilution to label 1x10^6 cells in 100ul.
Reconstitute with 1 ml of distilled water. After reconstitution, store product undiluted at 4°C in the dark.
CD21, also known as CR2, C3d receptor and EBV receptor), is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.