|Tested species reactivity||Mouse|
|Published species reactivity||Mouse, Not Applicable|
|Host / Isotype||Rat / IgG2a|
|Storage buffer||PBS, pH 7.2, with sucrose, 4mg/ml BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CD23 is a 45kDa glycoprotein, which is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. The CD23 molecule is identical to the low affinity IgE receptor found on B cells. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic lymphocyctic leukaemia and some cases of centroblastic/centrocytic lymphoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.
MCD2305 was used in flow cytometry to study the effect of ERK1/2 and ERK5 activation on BAFF-induced B cell survival
|Jacque E,Schweighoffer E,Tybulewicz VL,Ley SC||The Journal of experimental medicine (212:883)||2015|
|Not Applicable||Not Cited||
IkappaBalpha is required for marginal zone B cell lineage development.
MCD2305 was used in flow cytometry to investigate the role of nuclear factor-kappaB signaling in the development of marginal zone B cells
|Ellinghaus U,Rupec RA,Pabst O,Ignatius R,Förster R,Dörken B,Jundt F||European journal of immunology (38:2096)||2008|
IKK-induced NF-¿B1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen.
MCD2305 was used in flow cytometry to study IκB kinase-induced proteolysis of NF-κB1 p105 in B cells using Nfkb1(SSAA/SSAA) mice.
|Jacque E,Schweighoffer E,Visekruna A,Papoutsopoulou S,Janzen J,Zillwood R,Tarlinton DM,Tybulewicz VL,Ley SC||The Journal of experimental medicine (211:2085)||2014|
TLR4 promotes B cell maturation: independence and cooperation with B lymphocyte-activating factor.
MCD2305 was used in flow cytometry to report the cell surface markers and functional properties of B cells matured in vitro with LPS
|Hayashi EA,Granato A,Paiva LS,Bertho AL,Bellio M,Nobrega A||Journal of immunology (Baltimore, Md. : 1950) (184:4662)||2010|