T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells.
The Journal of biological chemistry
Tewari R,Shayahati B,Fan Y,Akimzhanov AM
12-0259-42 was used in Flow Cytometry to characterise lipidation (S-acylation) of the ZAP-70 tyrosine kinase using Acyl-Biotin Exchange assay, a technique that selectively captures S-acylated proteins.
Thu Aug 26 00:00:00 EDT 2021
Mucosal-associated invariant T cell responses differ by sex in COVID-19.
Med (New York, N.Y.)
Yu C,Littleton S,Giroux NS,Mathew R,Ding S,Kalnitsky J,Yang Y,Petzold E,Chung HA,Rivera GO,Rotstein T,Xi R,Ko ER,Tsalik EL,Sempowski GD,Denny TN,Burke TW,McClain MT,Woods CW,Shen X,Saban DR
12-0259-42 was used in Flow Cytometry to reveal a pronounced reduction of circulating mucosal-associated invariant T (MAIT) cells in infected females.
Fri Jun 11 00:00:00 EDT 2021
Th2 Biased Immunity With Altered B Cell Profiles in Circulation of Patients With Sporotrichosis Caused by Sporothrix globosa.
Frontiers in immunology
Zu J,Yao L,Song Y,Cui Y,Guan M,Chen R,Zhen Y,Li S
12-0259 was used in Flow cytometry/Cell sorting to shed light on the potential involvement of peripheral T and B cell immunity against this mycotic infection.
Mon May 31 00:00:00 EDT 2021
CRISPR-Cas9-mediated disruption of PD-1 on human T cells for adoptive cellular therapies of EBV positive gastric cancer.
Su S,Zou Z,Chen F,Ding N,Du J,Shao J,Li L,Fu Y,Hu B,Yang Y,Sha H,Meng F,Wei J,Huang X,Liu B
12-0259 was used in Flow cytometry/Cell sorting to study PD-1/PD-L1-mediated immune tolerance of Epstein-Barr virus-associated gastric cancer and provide a new strategy to break the tolerance for the T cell-based adoptive therapy.
Tue Jan 12 00:00:00 EST 2021
Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis.
Henderson LA,Hoyt KJ,Lee PY,Rao DA,Jonsson AH,Nguyen JP,Rutherford K,Julé AM,Charbonnier LM,Case S,Chang MH,Cohen EM,Dedeoglu F,Fuhlbrigge RC,Halyabar O,Hazen MM,Janssen E,Kim S,Lo J,Lo MS,Meidan E,Son MBF,Sundel RP,Stoll ML,Nusbaum C,Lederer JA,Chatila TA,Nigrovic PA
12-0259 was used in Flow cytometry/Cell sorting to show how systemic juvenile idiopathic arthritis (sJIA) transitions from acute to chronic through the evolving Th17 polarization that begins in Tregs and progresses to T effector cells (Teffs).
Thu Mar 26 00:00:00 EDT 2020
Human Fc Receptor-like 3 Inhibits Regulatory T Cell Function and Binds Secretory IgA.
Agarwal S,Kraus Z,Dement-Brown J,Alabi O,Starost K,Tolnay M
12-0259 was used in Flow cytometry/Cell sorting to study the functional regulation of T cells by human Fc receptor-like 3.
Tue Feb 04 00:00:00 EST 2020
Epigenetically modulated FOXM1 suppresses dendritic cell maturation in pancreatic cancer and colon cancer.
Zhou Z,Chen H,Xie R,Wang H,Li S,Xu Q,Xu N,Cheng Q,Qian Y,Huang R,Shao Z,Xiang M
12-0259 was used in Flow cytometry/Cell sorting to show that upregulation of FOXM1 by H3K79me2 in pancreatic cancer and colon cancer significantly inhibits maturation phenotypes and function of bone marrow dendritic cells (BMDCs) through the Wnt5a signaling pathway, and thus provide novel insights into FOXM1-based antitumor immunotherapy.
Mon Apr 01 00:00:00 EDT 2019
Functionalization-dependent effects of cellulose nanofibrils on tolerogenic mechanisms of human dendritic cells.
International journal of nanomedicine
Tomić S,Ilić N,Kokol V,Gruden-Movsesijan A,Mihajlović D,Bekić M,Sofronić-Milosavljević L,Čolić M,Vučević D
12-0259 was used in Flow cytometry/Cell sorting to investigate how differentially functionalised cellulose nanofibrils affect dendritic cell properties, their viability, morphology, differentiation and maturation potential, and the capacity to regulate T cell-mediated immune response.
Mon Dec 31 00:00:00 EST 2018
The Effects of High Mobility Group Box-1 Protein on Peripheral Treg/Th17 Balance in Patients with Atherosclerosis.
Acta Cardiologica Sinica
Ding JW,Zhou T,Zheng XX,Wang XA,Tong XH,Luo CY,Zhang ZQ,Yu B
12-0259 was used in Flow cytometry/Cell sorting to explore the mechanism of regulatory T cell/Th17 imbalance and the role of high mobility group box-1 protein on the balance in atherosclerosis.
Sat Sep 01 00:00:00 EDT 2018
Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing.
Zheng C,Zheng L,Yoo JK,Guo H,Zhang Y,Guo X,Kang B,Hu R,Huang JY,Zhang Q,Liu Z,Dong M,Hu X,Ouyang W,Peng J,Zhang Z
12-0259 was used in Flow cytometry/Cell sorting to characterise the RNA expression of infiltrating T cells in liver cancer.
Thu Jun 15 00:00:00 EDT 2017
Chemical proteomic map of dimethyl fumarate-sensitive cysteines in primary human T cells.
Blewett MM,Xie J,Zaro BW,Backus KM,Altman A,Teijaro JR,Cravatt BF
12-0259 was used in Flow cytometry/Cell sorting to explore the mode of action of Dimethyl fumarate as a therapy for autoimmune diseases.
Tue Sep 13 00:00:00 EDT 2016
Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition.
The Journal of biological chemistry
Ghosh S,Taylor A,Chin M,Huang HR,Conery AR,Mertz JA,Salmeron A,Dakle PJ,Mele D,Cote A,Jayaram H,Setser JW,Poy F,Hatzivassiliou G,DeAlmeida-Nagata D,Sandy P,Hatton C,Romero FA,Chiang E,Reimer T,Crawford T,Pardo E,Watson VG,Tsui V,Cochran AG,Zawadzke L,Harmange JC,Audia JE,Bryant BM,Cummings RT,Magnuson SR,Grogan JL,Bellon SF,Albrecht BK,Sims RJ,Lora JM
Fri Jun 17 00:00:00 EDT 2016
Age-Associated Differences in MiRNA Signatures Are Restricted to CD45RO Negative T Cells and Are Associated with Changes in the Cellular Composition, Activation and Cellular Ageing.
Teteloshvili N,Kluiver J,van der Geest KS,van der Lei RJ,Jellema P,Pawelec G,Brouwer E,Kroesen BJ,Boots AM,van den Berg A
12-0259 was used in Flow cytometry/Cell sorting to show that ageing related changes in miRNA expression are dominant in the CD45RO- T-cell compartment.
Thu Jun 09 00:00:00 EDT 2016
Impact of Pre-Transplant Anti-T Cell Globulin (ATG) on Immune Recovery after Myeloablative Allogeneic Peripheral Blood Stem Cell Transplantation.
Servais S,Menten-Dedoyart C,Beguin Y,Seidel L,Gothot A,Daulne C,Willems E,Delens L,Humblet-Baron S,Hannon M,Baron F
12-0259 was used in Flow cytometry/Cell sorting to assess the impact of anti-T cell globulin on the recovery of a large variety of lymphoid cell subsets as well as on thymic function after myeloablative peripheral blood stem cell transplantation.
Fri Apr 22 00:00:00 EDT 2016
CRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients.
Su S,Hu B,Shao J,Shen B,Du J,Du Y,Zhou J,Yu L,Zhang L,Chen F,Sha H,Cheng L,Meng F,Zou Z,Huang X,Liu B
12-0259 was used in Flow cytometry/Cell sorting to explore the effects of genetic disruption of the gene PD-1 on T cell viability, IFN-γ production and cytotoxicity.
Thu Jan 28 00:00:00 EST 2016
GITR engagement in combination with CTLA-4 blockade completely abrogates immunosuppression mediated by human liver tumor-derived regulatory T cells ex vivo.
Pedroza-Gonzalez A,Zhou G,Singh SP,Boor PP,Pan Q,Grunhagen D,de Jonge J,Tran TK,Verhoef C,IJzermans JN,Janssen H,Biermann K,Kwekkeboom J,Sprengers D
12-0259 was used in Flow cytometry/Cell sorting to investigate the ability of GITR-ligation and CTLA-4 blockade treatments to alleviate immunosuppression mediated by human liver tumor-derived regulatory T cells.
Tue Dec 01 00:00:00 EST 2015
Regulatory Dendritic Cells Restrain NK Cell IFN-γ Production through Mechanisms Involving NKp46, IL-10, and MHC Class I-Specific Inhibitory Receptors.
Journal of immunology (Baltimore, Md. : 1950)
Spallanzani RG,Torres NI,Avila DE,Ziblat A,Iraolagoitia XL,Rossi LE,Domaica CI,Fuertes MB,Rabinovich GA,Zwirner NW
12-0259 was used in Flow cytometry/Cell sorting to investigate the functional outcome of the interaction between regDC and NK cells and the associated underlying mechanisms.
Tue Sep 01 00:00:00 EDT 2015
Safety and immunologic correlates of Melanoma GVAX, a GM-CSF secreting allogeneic melanoma cell vaccine administered in the adjuvant setting.
Journal of translational medicine
Lipson EJ,Sharfman WH,Chen S,McMiller TL,Pritchard TS,Salas JT,Sartorius-Mergenthaler S,Freed I,Ravi S,Wang H,Luber B,Sproul JD,Taube JM,Pardoll DM,Topalian SL
12-0259 was used in Flow cytometry/Cell sorting to investigate the safety, tolerability and immunologic correlates of Melanoma GVAX.
Sun Jul 05 00:00:00 EDT 2015
Fine specificities of natural regulatory T cells after IVIG therapy in patients with Kawasaki disease.
Burns JC,Touma R,Song Y,Padilla RL,Tremoulet AH,Sidney J,Sette A,Franco A
12-0259 was used in Flow cytometry/Cell sorting to demonstrate an approach to expand the fragment crystallisable region-specific nTreg population to prevent the development of coronary artery abnormalities.
Fri May 01 00:00:00 EDT 2015
Severe impairment of regulatory T-cells and Th1-lymphocyte polarization in patients with Gaucher disease.
Sotiropoulos C,Theodorou G,Repa C,Marinakis T,Verigou E,Solomou E,Karakantza M,Symeonidis A
12-0259 was used in Flow cytometry/Cell sorting to investigate peripheral blood T-lymphocyte subpopulations and intracellular expression of various interleukins and interferons in type I Gaucher disease patients.
Tue Mar 17 00:00:00 EDT 2015
Neuropilin-1 expression characterizes T follicular helper (Tfh) cells activated during B cell differentiation in human secondary lymphoid organs.
Renand A,Milpied P,Rossignol J,Bruneau J,Lemonnier F,Dussiot M,Coulon S,Hermine O
12-0259 was used in Flow cytometry/Cell sorting to characterise Nrp1-expressing T cells in human secondary lymphoid organs.
Mon Feb 23 00:00:00 EST 2015
An increased abundance of tumor-infiltrating regulatory T cells is correlated with the progression and prognosis of pancreatic ductal adenocarcinoma.
Tang Y,Xu X,Guo S,Zhang C,Tang Y,Tian Y,Ni B,Lu B,Wang H
12-0259 was used in Flow cytometry/Cell sorting to reveal Tregs may promote PDA progression by inhibiting the antitumour immunity of CD8+ T cells at local intratumoural sites.
Tue Jan 06 00:00:00 EST 2015
Equisetum arvense (common horsetail) modulates the function of inflammatory immunocompetent cells.
BMC complementary and alternative medicine
Gründemann C,Lengen K,Sauer B,Garcia-Käufer M,Zehl M,Huber R
12-0259 was used in Flow cytometry/Cell sorting to understand the molecular basis for the use of common horsetail in the treatment of inflammatory disorders.
Mon Aug 04 00:00:00 EDT 2014
Small molecule inhibitor of antigen binding and presentation by HLA-DR2b as a therapeutic strategy for the treatment of multiple sclerosis.
Journal of immunology (Baltimore, Md. : 1950)
Ji N,Somanaboeina A,Dixit A,Kawamura K,Hayward NJ,Self C,Olson GL,Forsthuber TG
12-0259 was used in Flow cytometry/Cell sorting to investigate how blocking the HLA-DR2b allele with small molecule inhibitors may offer a promising therapeutic strategy for the treatment of multiple sclerosis.
Fri Nov 15 00:00:00 EST 2013
Calcineurin inhibitor treatment of intravenous immunoglobulin-resistant Kawasaki disease.
The Journal of pediatrics
Tremoulet AH,Pancoast P,Franco A,Bujold M,Shimizu C,Onouchi Y,Tamamoto A,Erdem G,Dodd D,Burns JC
12-0259 was used in Flow cytometry/Cell sorting to investigate treatment of refractory KD with a calcineurin inhibitor.
Sat Sep 01 00:00:00 EDT 2012
Inhibition of SLPI ameliorates disease activity in experimental autoimmune encephalomyelitis.
Müller AM,Jun E,Conlon H,Sadiq SA
12-0259 was used in Flow cytometry/Cell sorting to study how SLPI exerts potent pro-inflammatory actions by modulation of T-cell activity and its neutralization may be beneficial for EAE.
Wed Mar 21 00:00:00 EDT 2012
Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression.
Journal of leukocyte biology
Rossi LE,Avila DE,Spallanzani RG,Ziblat A,Fuertes MB,Lapyckyj L,Croci DO,Rabinovich GA,Domaica CI,Zwirner NW
12-0259 was used in Flow cytometry/Cell sorting to investigate the effect of histone deacetylase inhibitors on immune cells, showing that they can impair NK cell viability and effector functions.
Wed Feb 01 00:00:00 EST 2012
Immunophenotyping at the time of diagnosis distinguishes two groups of nasopharyngeal carcinoma patients: implications for adoptive immunotherapy.
International journal of biological sciences
Li J,Chen QY,Mo H,Zhang YL,Huang ZF,Zeng YX
12-0259 was used in Flow cytometry/Cell sorting to demonstrate that NPC patients could be distinguished on the basis of their immune status.
Thu Sep 15 00:00:00 EDT 2011
Angiopoietin 2 stimulates TIE2-expressing monocytes to suppress T cell activation and to promote regulatory T cell expansion.
Journal of immunology (Baltimore, Md. : 1950)
Coffelt SB,Chen YY,Muthana M,Welford AF,Tal AO,Scholz A,Plate KH,Reiss Y,Murdoch C,De Palma M,Lewis CE
12-0259 was used in Flow cytometry/Cell sorting to suggest that ANGPT2-stimulated TIE2-expressing monocytes/macrophages represent a novel, potent immunosuppressive force in tumours.
Fri Apr 01 00:00:00 EDT 2011
Flt3-L increases CD4+CD25+Foxp3+ICOS+ cells in the lungs of cockroach-sensitized and -challenged mice.
American journal of respiratory cell and molecular biology
McGee HS,Edwan JH,Agrawal DK
12-0259 was used in Flow cytometry/Cell sorting to suggest that the therapeutic effect of Flt3-L is mediated by increased density of CD41CD251Foxp31IL101ICOS1 T-regulatory cells in the lung.
Mon Mar 01 00:00:00 EST 2010
T-cell responses to survivin in cancer patients undergoing radiation therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research
Schaue D,Comin-Anduix B,Ribas A,Zhang L,Goodglick L,Sayre JW,Debucquoy A,Haustermans K,McBride WH
12-0259 was used in Flow cytometry/Cell sorting to show that radiation therapy may increase the likelihood of some cancer patients responding to immunotherapy.
Fri Aug 01 00:00:00 EDT 2008
Functional inactivation of EBV-specific T-lymphocytes in nasopharyngeal carcinoma: implications for tumor immunotherapy.
Li J,Zeng XH,Mo HY,Rolén U,Gao YF,Zhang XS,Chen QY,Zhang L,Zeng MS,Li MZ,Huang WL,Wang XN,Zeng YX,Masucci MG
12-0259 was used in Flow cytometry/Cell sorting to assess whether defects of EBV-specific immunity may contribute to tumoural growth.
Wed Nov 07 00:00:00 EST 2007
T regulatory cell levels decrease in people infected with Schistosoma mansoni on effective treatment.
The American journal of tropical medicine and hygiene
Watanabe K,Mwinzi PN,Black CL,Muok EM,Karanja DM,Secor WE,Colley DG
12-0259 was used in Flow cytometry/Cell sorting to investigate the role of Tregs in Schistosoma mansoni infection, showing that Treg levels decrease in people on effective treatment.
Mon Oct 01 00:00:00 EDT 2007