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      CD27 Monoclonal Antibody (CLB-27/1), PE

      See 48 other CD27 antibodies ›
      CD27 Monoclonal Antibody, PE conjugate for Flow

      Catalog#: MHCD2704 Invitrogen

      Catalog # Size Price (USD) Qty Datasheet
      MHCD2704 0.5 ml
      336.00
      Please enter a quantity in the range of 1 to 199.
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      Product Details

      References

      Bioinformatics

      Documents
      Details
      Tested species reactivity Human
      Published species reactivity Human
      Host / Isotype Mouse / IgG2a
      Class Monoclonal
      Type Antibody
      Clone CLB-27/1
      Immunogen Human CD27
      Conjugate PE
      Form Liquid
      Purification purified
      Storage buffer PBS with 4-5mg/ml BSA
      Contains 0.1% sodium azide
      Storage Conditions 4° C, store in dark
      Tested Applications Dilution *
      Flow Cytometry (Flow) Assay-Dependent

      * Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.

      Published Applications
      Flow Cytometry (Flow) See 1 publications below

      Product Specific Information

      R-phycoerythrin (PE) is a stable and highly soluble phycobiliprotein which provides maximal absorbance and fluorescence without susceptibility to internal or external fluorescence quenching, thus providing an exceptional quantum yields and molar extinction coefficients.

      Background/Target Information

      CD27 (50 kDa) is a member of the tumor necrosis factor (TNF) receptor superfamily. CD40 and CD30 are also members of the TNF receptor superfamily. The TNF superfamily members are known for the regulation of cell proliferation and death. In contrast to the expression of other TNFR/TNF family members, expression of CD27 and its ligand CD70 is predominantly confined to lymphocytes. High expression levels of CD27 appear to be dependent on proper ligation of antigen receptors. CD70 expression requires additional co-stimulatory and/or pro-inflammatory signals. CD27 is a membranebound receptor, but a soluble form of CD27 is also produced.

      Analyte Specific Reagent

      References

      Flow Cytometry

      Species Dilution Title Authors Journal (Vol:Pg) Year
      Human Not Cited CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation.
      MHCD2704 was used in flow cytometry to investigate the CSK polymorphism rs34933034 in B cells and lupus.       		Manjarrez-Orduño N,Marasco E,Chung SA,Katz MS,Kiridly JF,Simpfendorfer KR,Freudenberg J,Ballard DH,Nashi E,Hopkins TJ,Cunninghame Graham DS,Lee AT,Coenen MJ,Franke B,Swinkels DW,Graham RR,Kimberly RP,Gaffney PM,Vyse TJ,Behrens TW,Criswell LA,Diamond B,Gregersen PK Nature genetics (44:1227) 2012

      Documents

      Material safety data sheets (MSDS)

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