|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG2a|
|Storage buffer||PBS with 4-5mg/ml BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 1 publications below|
R-phycoerythrin (PE) is a stable and highly soluble phycobiliprotein which provides maximal absorbance and fluorescence without susceptibility to internal or external fluorescence quenching, thus providing an exceptional quantum yields and molar extinction coefficients.
CD27 (50 kDa) is a member of the tumor necrosis factor (TNF) receptor superfamily. CD40 and CD30 are also members of the TNF receptor superfamily. The TNF superfamily members are known for the regulation of cell proliferation and death. In contrast to the expression of other TNFR/TNF family members, expression of CD27 and its ligand CD70 is predominantly confined to lymphocytes. High expression levels of CD27 appear to be dependent on proper ligation of antigen receptors. CD70 expression requires additional co-stimulatory and/or pro-inflammatory signals. CD27 is a membranebound receptor, but a soluble form of CD27 is also produced.
Analyte Specific Reagent
CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation.
MHCD2704 was used in flow cytometry to investigate the CSK polymorphism rs34933034 in B cells and lupus.
|Manjarrez-Orduño N,Marasco E,Chung SA,Katz MS,Kiridly JF,Simpfendorfer KR,Freudenberg J,Ballard DH,Nashi E,Hopkins TJ,Cunninghame Graham DS,Lee AT,Coenen MJ,Franke B,Swinkels DW,Graham RR,Kimberly RP,Gaffney PM,Vyse TJ,Behrens TW,Criswell LA,Diamond B,Gregersen PK||Nature genetics (44:1227)||2012|