|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Mouse / IgG2a|
|Storage buffer||0.05M borate, pH 8.3, with 1M betaine|
|Contains||0.05% sodium azide|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CD27 (50 kDa) is a member of the tumor necrosis factor (TNF) receptor superfamily. CD40 and CD30 are also members of the TNF receptor superfamily. The TNF superfamily members are known for the regulation of cell proliferation and death. In contrast to the expression of other TNFR/TNF family members, expression of CD27 and its ligand CD70 is predominantly confined to lymphocytes. High expression levels of CD27 appear to be dependent on proper ligation of antigen receptors. CD70 expression requires additional co-stimulatory and/or pro-inflammatory signals. CD27 is a membranebound receptor, but a soluble form of CD27 is also produced.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Not Applicable||Not Cited||
Selective Loss of Early Differentiated, Highly Functional PD1high CD4 T Cells with HIV Progression.
Q10065 was used in flow cytometry to analyze HIV progression traits of a selective loss of early differentiated and highly functional PD1high CD4 T cells
|Paris RM,Petrovas C,Ferrando-Martinez S,Moysi E,Boswell KL,Archer E,Yamamoto T,Ambrozak D,Casazza JP,Haubrich R,Connors M,Ake J,Kim JH,Koup RA||PloS one (10:null)||2015|
Longitudinal studies of a B cell-derived signature of tolerance in renal transplant recipients.
Q10065 was used in flow cytometry to assess the role of B cells in tolerant kidney transplant recipients.
|Newell KA,Asare A,Sanz I,Wei C,Rosenberg A,Gao Z,Kanaparthi S,Asare S,Lim N,Stahly M,Howell M,Knechtle S,Kirk A,Marks WH,Kawai T,Spitzer T,Tolkoff-Rubin N,Sykes M,Sachs DH,Cosimi AB,Burlingham WJ,Phippard D,Turka LA||American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (15:2908)||2015|
Decreased influenza-specific B cell responses in rheumatoid arthritis patients treated with anti-tumor necrosis factor.
Q10065 was used in flow cytometry to test if B cell responses to antigen were compromised in rheumatoid arthritis patients treated with anti-TNF therapy.
|Kobie JJ,Zheng B,Bryk P,Barnes M,Ritchlin CT,Tabechian DA,Anandarajah AP,Looney RJ,Thiele RG,Anolik JH,Coca A,Wei C,Rosenberg AF,Feng C,Treanor JJ,Lee FE,Sanz I||Arthritis research and therapy (13:null)||2012|