|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Mouse / IgG2a|
|Storage buffer||0.05M borate, pH 8.3, with 1M betaine|
|Contains||0.05% sodium azide|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CD27 (50 kDa) is a member of the tumor necrosis factor (TNF) receptor superfamily. CD40 and CD30 are also members of the TNF receptor superfamily. The TNF superfamily members are known for the regulation of cell proliferation and death. In contrast to the expression of other TNFR/TNF family members, expression of CD27 and its ligand CD70 is predominantly confined to lymphocytes. High expression levels of CD27 appear to be dependent on proper ligation of antigen receptors. CD70 expression requires additional co-stimulatory and/or pro-inflammatory signals. CD27 is a membranebound receptor, but a soluble form of CD27 is also produced.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Subinfectious hepatitis C virus exposures suppress T cell responses against subsequent acute infection.
Q10066 was used in flow cytometry to decipher how susequent acute infection is supressed in T cell responses after exposure to subinfectious hepatitis C virus
|Park SH,Veerapu NS,Shin EC,Biancotto A,McCoy JP,Capone S,Folgori A,Rehermann B||Nature medicine (19:1638)||2013|
Capsid-specific T-cell responses to natural infections with adeno-associated viruses in humans differ from those of nonhuman primates.
Q10066 was used in flow cytometry to test if rejection of AAV-transduced hepatocytes is due to AAV capsid-specific CD8 positive T cells that become reactivated upon gene transfer.
|Li H,Lasaro MO,Jia B,Lin SW,Haut LH,High KA,Ertl HC||Molecular therapy : the journal of the American Society of Gene Therapy (19:2021)||2011|
Effects of immunosuppression on circulating adeno-associated virus capsid-specific T cells in humans.
Q10066 was used in immunocytochemistry to assess the effect of immunosuppression used for organ transplantation on immune responses to adeno-associated virus capsid antigens.
|Parzych EM,Li H,Yin X,Liu Q,Wu TL,Podsakoff GM,High KA,Levine MH,Ertl HC||Human gene therapy (24:431)||2013|
9G4 autoreactivity is increased in HIV-infected patients and correlates with HIV broadly neutralizing serum activity.
Q10066 was used in flow cytometry to assess the breakdown of tolerance in HIV patients.
|Kobie JJ,Alcena DC,Zheng B,Bryk P,Mattiacio JL,Brewer M,Labranche C,Young FM,Dewhurst S,Montefiori DC,Rosenberg AF,Feng C,Jin X,Keefer MC,Sanz I||PloS one (7:null)||2012|