Product References
PD-L1 Exon 3 Is a Hidden Switch of Its Expression and Function in Oral Cancer Cells.
International journal of molecular sciences
Yan L,Sun Y,Guo J,Jia R
17-5983-42 was used in Flow cytometry/Cell sorting to demonstrate the pivotal roles of exon 3 in PD-L1 expression and provide a novel anti-PD-L1 method.
Wed May 03 00:00:00 UTC 2023
Base editing screens map mutations affecting interferon-γ signaling in cancer.
Cancer cell
Coelho MA,Cooper S,Strauss ME,Karakoc E,Bhosle S,Gonçalves E,Picco G,Burgold T,Cattaneo CM,Veninga V,Consonni S,Dinçer C,Vieira SF,Gibson F,Barthorpe S,Hardy C,Rein J,Thomas M,Marioni J,Voest EE,Bassett A,Garnett MJ
17-5983-42 was used in Flow Cytometry to identify more than 300 predicted missense mutations altering IFN-γ pathway activity, generating a valuable resource for interpreting gene variant function.
Mon Feb 13 00:00:00 UTC 2023
Evidence of SARS-CoV-2 infection in postmortem lung, kidney, and liver samples, revealing cellular targets involved in COVID-19 pathogenesis.
Archives of virology
Falcón-Cama V,Montero-González T,Acosta-Medina EF,Guillen-Nieto G,Berlanga-Acosta J,Fernández-Ortega C,Alfonso-Falcón A,Gilva-Rodríguez N,López-Nocedo L,Cremata-García D,Matos-Terrero M,Pentón-Rol G,Valdés I,Oramas-Díaz L,Suarez-Batista A,Noa-Romero E,Cruz-Sui O,Sánchez D,Borrego-Díaz AI,Valdés-Carreras JE,Vizcaino A,Suárez-Alba J,Valdés-Véliz R,Bergado G,González MA,Hernandez T,Alvarez-Arzola R,Ramírez-Suárez AC,Casillas-Casanova D,Lemos-Pérez G,Blanco-Águila OR,Díaz A,González Y,Bequet-Romero M,Marín-Prida J,Hernández-Perera JC,Del Rosario-Cruz L,Marin-Díaz AP,González-Bravo M,Borrajero I,Acosta-Rivero N
17-5983-42 was used in flow cytometry to identify the SARS-CoV-2 nucleocapsid (NC) in a variety of cells, colocalizing with mitochondrial proteins, lipid droplets (LDs), and key host proteins that have been implicated in inflammation, tissue repair, and the SARS-CoV-2 life cycle (vimentin, NLRP3, fibronectin, LC3B, DDX3X, and PPARγ), pointing to vimentin and LDs as platforms involved not only in the viral life cycle but also in inflammation and pathogenesis.
Sun Feb 26 00:00:00 UTC 2023
HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway.
Journal of experimental & clinical cancer research : CR
Liu Y,Xu Q,Deng F,Zheng Z,Luo J,Wang P,Zhou J,Lu X,Zhang L,Chen Z,Zhang Q,Chen Q,Zuo D
17-5983-42 was used in Flow cytometry/Cell sorting to identify HERC2 functions as a previously unknown modulator of the JAK2/STAT3 pathway, thereby promoting inflammation-induced stemness and immune evasion in HCC.
Wed Feb 01 00:00:00 UTC 2023
A secondary role for hypoxia and HIF1 in the regulation of (IFNγ-induced) PD-L1 expression in melanoma.
Cancer immunology, immunotherapy : CII
van Duijn A,Willemsen KJ,van Uden NOP,Hoyng L,Erades S,Koster J,Luiten RM,Bakker WJ
17-5983-42 was used in Flow Cytometry to show the influence of hypoxia on IFNγ-induced PD-L1 expression, are relevant for immunotherapy, as both IFNγ and hypoxia are frequently present in the tumor microenvironment.
Tue Mar 01 00:00:00 UTC 2022
Exosomal CD73 from serum of patients with melanoma suppresses lymphocyte functions and is associated with therapy resistance to anti-PD-1 agents.
Journal for immunotherapy of cancer
Turiello R,Capone M,Morretta E,Monti MC,Madonna G,Azzaro R,Del Gaudio P,Simeone E,Sorrentino A,Ascierto PA,Morello S
17-5983-42 was used in Flow cytometry/Cell sorting to evaluate levels of exosomal CD73 before and early during treatment with anti-PD-1 agents in patients with melanoma and its potential contribution to affect T-cell functions and to influence the clinical outcomes of anti-PD-1 monotherapy.
Tue Mar 01 00:00:00 UTC 2022
YIV-906 enhances nuclear factor of activated T-cells (NFAT) activity of T cells and promotes immune checkpoint blockade antibody action and CAR T-cell activity.
Frontiers in pharmacology
Lam W,Hu R,Liu SH,Cheng P,Cheng YC
17-5983-42 was used in Flow cytometry/Cell sorting to show that YIV-906 modulates adaptive immunity by activating T effector cells mainly through its action on SHP1/2.
Wed Feb 01 00:00:00 UTC 2023
PRDX-1 Supports the Survival and Antitumor Activity of Primary and CAR-Modified NK Cells under Oxidative Stress.
Cancer immunology research
Klopotowska M,Bajor M,Graczyk-Jarzynka A,Kraft A,Pilch Z,Zhylko A,Firczuk M,Baranowska I,Lazniewski M,Plewczynski D,Goral A,Soroczynska K,Domagala J,Marhelava K,Slusarczyk A,Retecki K,Ramji K,Krawczyk M,Temples MN,Sharma B,Lachota M,Netskar H,Malmberg KJ,Zagozdzon R,Winiarska M
17-5983-42 was used in Flow cytometry/Cell sorting to demonstrate that hydrogen peroxide, at concentrations detected in the TME, suppresses NK cell function and that genetic modification strategies can improve CAR NK cells' resistance and potency against solid tumors.
Tue Feb 01 00:00:00 UTC 2022
CRISPR Screening of CAR T Cells and Cancer Stem Cells Reveals Critical Dependencies for Cell-Based Therapies.
Cancer discovery
Wang D,Prager BC,Gimple RC,Aguilar B,Alizadeh D,Tang H,Lv D,Starr R,Brito A,Wu Q,Kim LJY,Qiu Z,Lin P,Lorenzini MH,Badie B,Forman SJ,Xie Q,Brown CE,Rich JN
17-5983-42 was used in Flow Cytometry to interrogate molecular determinants of CAR-mediated GBM killing through whole-genome CRISPR screens in both CAR T cells and patient-derived GSCs.
Sat May 01 00:00:00 UTC 2021
LSD1 silencing contributes to enhanced efficacy of anti-CD47/PD-L1 immunotherapy in cervical cancer.
Cell death & disease
Xu S,Wang X,Yang Y,Li Y,Wu S
17-5983-42 was used in Flow Cytometry to validate the increase in expression of LSD1 during the progression of cervical cancer and confirmed the enhanced therapeutic effect against cervical cancer when combining CD47/PD-L1 blockade therapy with an LSD1 inhibitor.
Wed Mar 17 00:00:00 UTC 2021
Bispecific T-Cell Engaging Antibodies Against MUC16 Demonstrate Efficacy Against Ovarian Cancer in Monotherapy and in Combination With PD-1 and VEGF Inhibition.
Frontiers in immunology
Yeku OO,Rao TD,Laster I,Kononenko A,Purdon TJ,Wang P,Cui Z,Liu H,Brentjens RJ,Spriggs D
17-5983-42 was used in Flow Cytometry to show the feasibility and efficacy of human MUC16 ectodomain- specific BiTEDs and provide a basis for the combination with anti-VEGF therapy for ovarian cancer.
Thu Oct 21 00:00:00 UTC 2021
T cells drive negative feedback mechanisms in cancer associated fibroblasts, promoting expression of co-inhibitory ligands, CD73 and IL-27 in non-small cell lung cancer.
Oncoimmunology
O'Connor RA,Chauhan V,Mathieson L,Titmarsh H,Koppensteiner L,Young I,Tagliavini G,Dorward DA,Prost S,Dhaliwal K,Wallace WA,Akram AR
17-5983-42 was used in Flow Cytometry to study co-inhibitory ligands in T cell immunosuppression in non-small cell lung cancer.
Mon Aug 02 00:00:00 UTC 2021
Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly.
Cell
Giamarellos-Bourboulis EJ,Tsilika M,Moorlag S,Antonakos N,Kotsaki A,Domínguez-Andrés J,Kyriazopoulou E,Gkavogianni T,Adami ME,Damoraki G,Koufargyris P,Karageorgos A,Bolanou A,Koenen H,van Crevel R,Droggiti DI,Renieris G,Papadopoulos A,Netea MG
17-5983-42 was used in Flow Cytometry to assess whether BCG has similar effects in the elderly in a phase III ACTIVATE trial.
Thu Oct 15 00:00:00 UTC 2020
Multidimensional analyses of proinsulin peptide-specific regulatory T cells induced by tolerogenic dendritic cells.
Journal of autoimmunity
Suwandi JS,Laban S,Vass K,Joosten A,van Unen V,Lelieveldt BPF,Höllt T,Zwaginga JJ,Nikolic T,Roep BO
17-5983-42 was used in Flow Cytometry to investigate if tolerogenic dendritic cells can induce antigen-specific T-cells.
Sat Feb 01 00:00:00 UTC 2020
CD44 Promotes PD-L1 Expression and Its Tumor-Intrinsic Function in Breast and Lung Cancers.
Cancer research
Kong T,Ahn R,Yang K,Zhu X,Fu Z,Morin G,Bramley R,Cliffe NC,Xue Y,Kuasne H,Li Q,Jung S,Gonzalez AV,Camilleri-Broet S,Guiot MC,Park M,Ursini-Siegel J,Huang S
17-5983 was used in Flow cytometry/Cell sorting to provide a novel basis for CD44 as a critical therapeutic target to suppress PD-L1 tumor-intrinsic function.
Sat Feb 01 00:00:00 UTC 2020
The Immunostimulative Effect and Mechanisms of a Novel Mouse Anti-Human PD-1 Monoclonal Antibody on Jurkat Lymphocytic Cells Cocultured with Hepatoma Cells.
OncoTargets and therapy
Li Z,Li B,Li L,Wang G,Li Y,Fu R,Ming Y,Ni R,Wang J,Ye G,Chen J
17-5983 was used in Western Blotting to demonstrated that anti-PD-1 mAb B1C4 could inhibit the apoptosis of Jurkat cells induced by HePG2 hepatoma cells and reverse the immunosuppressive effect of HePG2 cells on Jurkat cells.
Mon Apr 18 00:00:00 UTC 2022
BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils.
Cell reports
Moorlag SJCFM,Rodriguez-Rosales YA,Gillard J,Fanucchi S,Theunissen K,Novakovic B,de Bont CM,Negishi Y,Fok ET,Kalafati L,Verginis P,Mourits VP,Koeken VACM,de Bree LCJ,Pruijn GJM,Fenwick C,van Crevel R,Joosten LAB,Joosten I,Koenen H,Mhlanga MM,Diavatopoulos DA,Chavakis T,Netea MG
17-5983-42 was used in flow cytometry to show that BCG vaccination of healthy humans induces long-lasting changes in neutrophil phenotype, characterized by increased expression of activation markers and antimicrobial function.
Tue Nov 17 00:00:00 UTC 2020
HGF-Induced PD-L1 Expression in Head and Neck Cancer: Preclinical and Clinical Findings.
International journal of molecular sciences
Boschert V,Teusch J,Aljasem A,Schmucker P,Klenk N,Straub A,Bittrich M,Seher A,Linz C,Müller-Richter UDA,Hartmann S
17-5983 was used in Flow cytometry/Cell sorting to indicate a potential role for sPD-L1 as a prognostic marker for immune checkpoint inhibitor treatment in head neck squamous cell carcinoma.
Fri Nov 20 00:00:00 UTC 2020
CA-170 - A Potent Small-Molecule PD-L1 Inhibitor or Not?
Molecules (Basel, Switzerland)
Musielak B,Kocik J,Skalniak L,Magiera-Mularz K,Sala D,Czub M,Stec M,Siedlar M,Holak TA,Plewka J
17-5983 was used in Flow cytometry/Cell sorting to perform control experiments on AUNP-12 - a 29-mer peptide, which is a precursor of CA-170. Positive controls consisted of the well-documented small-molecule PD-L1 inhibitors: BMS-1166 and peptide-57.
Thu Aug 01 00:00:00 UTC 2019
Synergistic inhibition of pancreatic cancer with anti-PD-L1 and c-Myc inhibitor JQ1.
Oncoimmunology
Pan Y,Fei Q,Xiong P,Yang J,Zhang Z,Lin X,Pan M,Lu F,Huang H
17-5983-42 was used in Flow Cytometry to demonstrate that the expression of PD-L1 and c-Myc may be helpful prognostic biomarkers, and their inhibition may potentially serve as an effective treatment for PDAC.
Tue Jan 12 00:00:00 UTC 2021
Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids.
Cell
Dijkstra KK,Cattaneo CM,Weeber F,Chalabi M,van de Haar J,Fanchi LF,Slagter M,van der Velden DL,Kaing S,Kelderman S,van Rooij N,van Leerdam ME,Depla A,Smit EF,Hartemink KJ,de Groot R,Wolkers MC,Sachs N,Snaebjornsson P,Monkhorst K,Haanen J,Clevers H,Schumacher TN,Voest EE
17-5983-42 was used in Flow Cytometry to describe a platform to induce and analyze tumor-specific T cell responses to epithelial cancers in a personalized manner.
Thu Sep 06 00:00:00 UTC 2018
Similarities and differences between helminth parasites and cancer cell lines in shaping human monocytes: Insights into parallel mechanisms of immune evasion.
PLoS neglected tropical diseases
Narasimhan PB,Akabas L,Tariq S,Huda N,Bennuru S,Sabzevari H,Hofmeister R,Nutman TB,Tolouei Semnani R
17-5983 was used in Flow cytometry/Cell sorting to suggest that despite the fact that helminth parasites and cancer cell lines are extraordinarily disparate, they share the ability to alter the phenotype of human monocytes.
Sun Apr 01 00:00:00 UTC 2018
Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination.
Cancer research
Jiang H,Rivera-Molina Y,Gomez-Manzano C,Clise-Dwyer K,Bover L,Vence LM,Yuan Y,Lang FF,Toniatti C,Hossain MB,Fueyo J
17-5983 was used in Flow cytometry/Cell sorting to demonstrate that combining an oncolytic virus with tumor-targeting immune checkpoint modulators elicits potent in situ autologous cancer vaccination, resulting in an efficacious, tumor-specific, and long-lasting therapeutic effect.
Sat Jul 15 00:00:00 UTC 2017
Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression.
Oncoimmunology
Layer JP,Kronmüller MT,Quast T,van den Boorn-Konijnenberg D,Effern M,Hinze D,Althoff K,Schramm A,Westermann F,Peifer M,Hartmann G,Tüting T,Kolanus W,Fischer M,Schulte J,Hölzel M
17-5983 was used in Flow cytometry to investigate the molecular characteristics of T-cell infiltration in primary neuroblastomas as an indicator of pre-existing immune responses and potential responsiveness to checkpoint inhibition.
Tue Jan 12 00:00:00 UTC 2021
Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition.
The Journal of clinical investigation
Cherkassky L,Morello A,Villena-Vargas J,Feng Y,Dimitrov DS,Jones DR,Sadelain M,Adusumilli PS
17-5983 was used in Flow cytometry/Cell sorting to provide mechanistic insights into human chimeric antigen receptor T-cell exhaustion in solid tumors.
Mon Aug 01 00:00:00 UTC 2016
Correlation of PD-L1 Surface Expression on Leukemia Cells with the Ratio of PD-L1 mRNA Variants and with Electrophoretic Mobility.
Cancer immunology research
Brodská B,Otevřelová P,Kuželová K
17-5983 was used in Western blot to show that the expression of PD-L1 on the surface of leukemic and normal hematopoietic cells correlates with the ratio of mRNA variant 1 to variant 2.
Sat Oct 01 00:00:00 UTC 2016
High and interrelated rates of PD-L1+CD14+ antigen-presenting cells and regulatory T cells mark the microenvironment of metastatic lymph nodes from patients with cervical cancer.
Cancer immunology research
Heeren AM,Koster BD,Samuels S,Ferns DM,Chondronasiou D,Kenter GG,Jordanova ES,de Gruijl TD
17-5983 was used in Immunocytochemistry-immunoflourescence to investigate the microenvironment of tumour-draining lymph nodes of patients with cervical cancer.
Thu Jan 01 00:00:00 UTC 2015
PDL1 Expression on Plasma and Dendritic Cells in Myeloma Bone Marrow Suggests Benefit of Targeted anti PD1-PDL1 Therapy.
PloS one
Sponaas AM,Moharrami NN,Feyzi E,Standal T,Holth Rustad E,Waage A,Sundan A
17-5983 was used in Flow cytometry/Cell sorting to investigate whether anti PDL1 or PD-1 treatment targeting the immune system could be used against multiple myeloma.
Fri Jun 03 00:00:00 UTC 2016
Impact of Diverse Immune Evasion Mechanisms of Cancer Cells on T Cells Engaged by EpCAM/CD3-Bispecific Antibody Construct AMG 110.
PloS one
Deisting W,Raum T,Kufer P,Baeuerle PA,Münz M
17-5983 was used in Flow cytometry/Cell sorting to suggest that diverse mechanisms employed by cancer cells to fend off T-cells cannot inactivate AMG 110-engaged T-cells.
Thu Jun 16 00:00:00 UTC 2016
Vitamin D regulates cytokine patterns secreted by dendritic cells to promote differentiation of IL-22-producing T cells.
PloS one
Sommer A,Fabri M
17-5983 was used in Flow cytometry/Cell sorting to study the role of vitamin D in regulating dendritic cell-mediated immune responses in humans.
Tue Apr 26 00:00:00 UTC 2016
HIV-1 Tat protein induces PD-L1 (B7-H1) expression on dendritic cells through tumor necrosis factor alpha- and toll-like receptor 4-mediated mechanisms.
Journal of virology
Planès R,BenMohamed L,Leghmari K,Delobel P,Izopet J,Bahraoui E
17-5983 was used in Functional assays to investigate the mechanisms by which HIV-1 induces upregulation of coinhibitory molecules, showing that the HIV-1 Tat protein induces PD-L1 expression on dendritic cells.
Sun Jun 01 00:00:00 UTC 2014
Major depletion of plasmacytoid dendritic cells in HIV-2 infection, an attenuated form of HIV disease.
PLoS pathogens
Cavaleiro R,Baptista AP,Soares RS,Tendeiro R,Foxall RB,Gomes P,Victorino RM,Sousa AE
17-5983 was used in Flow cytometry/Cell sorting to understand the contribution of plasmacytoid dendritic cell biology to HIV/AIDS pathogenesis.
Sun Nov 01 00:00:00 UTC 2009
Regulatory T cell (Treg) subsets return in patients with refractory lupus following stem cell transplantation, and TGF-beta-producing CD8+ Treg cells are associated with immunological remission of lupus.
Journal of immunology (Baltimore, Md. : 1950)
Zhang L,Bertucci AM,Ramsey-Goldman R,Burt RK,Datta SK
17-5983 was used in Flow cytometry/Cell sorting to show that after hemopoietic stem cell posttransplant patients certain Treg populations return to levels seen in healthy patient.
Sun Nov 15 00:00:00 UTC 2009
Expression of B7-H1 in inflammatory renal tubular epithelial cells.
Nephron. Experimental nephrology
Chen Y,Zhang J,Li J,Zou L,Zhao T,Tang Y,Wu Y
Fri Apr 21 00:00:00 UTC 2006
Expression of B7-H1 in inflammatory renal tubular epithelial cells.
Nephron. Experimental nephrology
Chen Y,Zhang J,Li J,Zou L,Zhao T,Tang Y,Wu Y
Fri Apr 21 00:00:00 UTC 2006
Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Ohigashi Y,Sho M,Yamada Y,Tsurui Y,Hamada K,Ikeda N,Mizuno T,Yoriki R,Kashizuka H,Yane K,Tsushima F,Otsuki N,Yagita H,Azuma M,Nakajima Y
Fri Apr 15 00:00:00 UTC 2005
