Product References
N-cadherin inhibitor creates a microenvironment that protect TILs from immune checkpoints and Treg cells.
Journal for immunotherapy of cancer
Sun Y,Jing J,Xu H,Xu L,Hu H,Tang C,Liu S,Wei Q,Duan R,Guo J,Yang L
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 14-5982-82) in Neutralization
Mon Mar 01 00:00:00 EST 2021
Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells.
Oncoimmunology
Salerno F,Guislain A,Freen-Van Heeren JJ,Nicolet BP,Young HA,Wolkers MC
14-5982 was used in Flow cytometry/Cell sorting to conclude that post-transcriptional mechanisms could be modulated to potentiate effective T cell therapies in cancer.
Tue Jan 12 00:00:00 EST 2021
Progranulin induces immune escape in breast cancer via up-regulating PD-L1 expression on tumor-associated macrophages (TAMs) and promoting CD8+ T cell exclusion.
Journal of experimental & clinical cancer research : CR
Fang W,Zhou T,Shi H,Yao M,Zhang D,Qian H,Zeng Q,Wang Y,Jin F,Chai C,Chen T
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 14-5982-82) in Neutralization
Mon Jan 04 00:00:00 EST 2021
CD279 mediates the homeostasis and survival of regulatory T cells by enhancing T cell and macrophage interactions.
FEBS open bio
Liu Y,Gao Y,Hao H,Hou T
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 14-5982-82) in Functional assay
Mon Jun 01 00:00:00 EDT 2020
CD279 mediates the homeostasis and survival of regulatory T cells by enhancing T cell and macrophage interactions.
FEBS open bio
Liu Y,Gao Y,Hao H,Hou T
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 14-5982-82) in Functional assay
Mon Jun 01 00:00:00 EDT 2020
Downregulation of PD-L1 via amide analogues of brefelamide: Alternatives to antibody-based cancer immunotherapy.
Experimental and therapeutic medicine
Zhang J,Yamada O,Kida S,Murase S,Hattori T,Oshima Y,Kikuchi H
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 14-5982-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms.
Journal for immunotherapy of cancer
Neuwelt AJ,Kimball AK,Johnson AM,Arnold BW,Bullock BL,Kaspar RE,Kleczko EK,Kwak JW,Wu MH,Heasley LE,Doebele RC,Li HY,Nemenoff RA,Clambey ET
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 14-5982-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis.
Nature cell biology
Zhu L,Li Y,Xie X,Zhou X,Gu M,Jie Z,Ko CJ,Gao T,Hernandez BE,Cheng X,Sun SC
14-5982 was used in Flow cytometry/Cell sorting to suggest a PKCθ-TBKBP1-TBK1 growth factor signalling axis that mediates both tumour growth and immunosuppression.
Sun Dec 01 00:00:00 EST 2019
Inhibition of ATM reverses EMT and decreases metastatic potential of cisplatin-resistant lung cancer cells through JAK/STAT3/PD-L1 pathway.
Journal of experimental & clinical cancer research : CR
Shen M,Xu Z,Xu W,Jiang K,Zhang F,Ding Q,Xu Z,Chen Y
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 14-5982-82) in Neutralization
Mon Apr 08 00:00:00 EDT 2019
Reactive glia promote development of CD103+ CD69+ CD8+ T-cells through programmed cell death-ligand 1 (PD-L1).
Immunity, inflammation and disease
Prasad S,Hu S,Sheng WS,Chauhan P,Lokensgard JR
14-5982 was used in Flow cytometry/Cell sorting to demonstrate a role for activated glia in promoting development of bTRM through the PD-1: PD-L1 pathway.
Fri Jun 01 00:00:00 EDT 2018
Critical role of plasmacytoid dendritic cells in induction of oral tolerance.
The Journal of allergy and clinical immunology
Uto T,Takagi H,Fukaya T,Nasu J,Fukui T,Miyanaga N,Arimura K,Nakamura T,Choijookhuu N,Hishikawa Y,Sato K
14-5982 was used in Flow cytometry/Cell sorting to determine the role of plasmacytoid dendritic cells (pDCs).
Fri Jun 01 00:00:00 EDT 2018
ATM‑JAK‑PD‑L1 signaling pathway inhibition decreases EMT and metastasis of androgen‑independent prostate cancer.
Molecular medicine reports
Zhang L,Xu LJ,Zhu J,Li J,Xue BX,Gao J,Sun CY,Zang YC,Zhou YB,Yang DR,Shan YX
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 14-5982-82) in Immunofluorescence
Tue May 01 00:00:00 EDT 2018
PD-L1 in tumor microenvironment mediates resistance to oncolytic immunotherapy.
The Journal of clinical investigation
Zamarin D,Ricca JM,Sadekova S,Oseledchyk A,Yu Y,Blumenschein WM,Wong J,Gigoux M,Merghoub T,Wolchok JD
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 14-5982-82) in Flow Cytometry
Mon Apr 02 00:00:00 EDT 2018
Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.
Nature communications
Sun C,Lan P,Han Q,Huang M,Zhang Z,Xu G,Song J,Wang J,Wei H,Zhang J,Sun R,Zhang C,Tian Z
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 14-5982-82) in Flow Cytometry
Wed Mar 28 00:00:00 EDT 2018
Systemic Antitumor Immunity by PD-1/PD-L1 Inhibition Is Potentiated by Vascular-Targeted Photodynamic Therapy of Primary Tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research
O'Shaughnessy MJ,Murray KS,La Rosa SP,Budhu S,Merghoub T,Somma A,Monette S,Kim K,Corradi RB,Scherz A,Coleman JA
14-5982 was used in Flow cytometry/Cell sorting to investigate the effects of vascular-targeted photodynamic therapy on the anti-tumour response to PD-1pathway inhibition.
Thu Feb 01 00:00:00 EST 2018
Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA.
Immunity
Coelho MA,de Carné Trécesson S,Rana S,Zecchin D,Moore C,Molina-Arcas M,East P,Spencer-Dene B,Nye E,Barnouin K,Snijders AP,Lai WS,Blackshear PJ,Downward J
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 14-5982-82) in Flow Cytometry
Tue Dec 19 00:00:00 EST 2017
Prostate Cancer Cells Express More Androgen Receptor (AR) Following Androgen Deprivation, Improving Recognition by AR-Specific T Cells.
Cancer immunology research
Olson BM,Gamat M,Seliski J,Sawicki T,Jeffery J,Ellis L,Drake CG,Weichert J,McNeel DG
14-5982 was used in Flow cytometry/Cell sorting to suggest that ADT combined with AR-directed immunotherapy targets a major mechanism of resistance, overexpression of the AR.
Fri Dec 01 00:00:00 EST 2017
Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology.
PloS one
Selby MJ,Engelhardt JJ,Johnston RJ,Lu LS,Han M,Thudium K,Yao D,Quigley M,Valle J,Wang C,Chen B,Cardarelli PM,Blanset D,Korman AJ
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 14-5982-82) in Immunohistochemistry
Fri Aug 25 00:00:00 EDT 2017
Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology.
PloS one
Selby MJ,Engelhardt JJ,Johnston RJ,Lu LS,Han M,Thudium K,Yao D,Quigley M,Valle J,Wang C,Chen B,Cardarelli PM,Blanset D,Korman AJ
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 14-5982-82) in Immunohistochemistry
Fri Aug 25 00:00:00 EDT 2017
Neuronal IFN-beta-induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1+Treg cells.
Nature communications
Liu Y,Marin A,Ejlerskov P,Rasmussen LM,Prinz M,Issazadeh-Navikas S
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 14-5982-82) in Western Blot
Mon Apr 24 00:00:00 EDT 2017
Enhanced antitumor effects by combining an IL-12/anti-DNA fusion protein with avelumab, an anti-PD-L1 antibody.
Oncotarget
Fallon JK,Vandeveer AJ,Schlom J,Greiner JW
14-5982 was used in Immunohistochemistry to study the therapeutic potential of an IL-12/anti-DNA fusion protein combined with avelumab treatment against solid tumours.
Tue Mar 28 00:00:00 EDT 2017
Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression.
Nature communications
Kalkavan H,Sharma P,Kasper S,Helfrich I,Pandyra AA,Gassa A,Virchow I,Flatz L,Brandenburg T,Namineni S,Heikenwalder M,Höchst B,Knolle PA,Wollmann G,von Laer D,Drexler I,Rathbun J,Cannon PM,Scheu S,Bauer J,Chauhan J,Häussinger D,Willimsky G,Löhning M,Schadendorf D,Brandau S,Schuler M,Lang PA,Lang KS
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 14-5982-82) in Immunofluorescence
Wed Mar 01 00:00:00 EST 2017
TGF-β inhibitor Smad7 regulates dendritic cell-induced autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America
Lukas D,Yogev N,Kel JM,Regen T,Mufazalov IA,Tang Y,Wanke F,Reizis B,Müller W,Kurschus FC,Prinz M,Kleiter I,Clausen BE,Waisman A
14-5982 was used in Flow cytometry/Cell sorting to demonstrate the role of Smad7 in the differentiation of dendritic cells in mice and their influence on the efficient function in immunity.
Tue Feb 21 00:00:00 EST 2017
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity.
Proceedings of the National Academy of Sciences of the United States of America
Chamoto K,Chowdhury PS,Kumar A,Sonomura K,Matsuda F,Fagarasan S,Honjo T
14598282 was used in flow cytometry to characterize mitochondrial changes in T cells due to PD-1 blockade therapy
Tue Jan 31 00:00:00 EST 2017
Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer.
Gut
Zhang Y,Velez-Delgado A,Mathew E,Li D,Mendez FM,Flannagan K,Rhim AD,Simeone DM,Beatty GL,Pasca di Magliano M
14598282 was used in immunohistochemistry and western blot to discuss the role of myeloid cells in pancreatic cancer pathogenesis
Sun Jan 01 00:00:00 EST 2017
Th2 responses are primed by skin dendritic cells with distinct transcriptional profiles.
The Journal of experimental medicine
Connor LM,Tang SC,Cognard E,Ochiai S,Hilligan KL,Old SI,Pellefigues C,White RF,Patel D,Smith AA,Eccles DA,Lamiable O,McConnell MJ,Ronchese F
14-5982 was used in Flow cytometry/Cell sorting to show the priming of Th2 responses is associated with distinct transcriptional signatures in dendritic cells in vivo, reflecting the diverse environments in which Th2 immune responses are initiated.
Sun Jan 01 00:00:00 EST 2017
CD301b+ dendritic cells suppress T follicular helper cells and antibody responses to protein antigens.
eLife
Kumamoto Y,Hirai T,Wong PW,Kaplan DH,Iwasaki A
14-5982 was used in Flow cytometry/Cell sorting to demonstrate a novel function of CD301b+ dendritic cells in negatively regulating antibody responses and preventing autoantibody formation.
Thu Sep 22 00:00:00 EDT 2016
Poxvirus-Based Active Immunotherapy with PD-1 and LAG-3 Dual Immune Checkpoint Inhibition Overcomes Compensatory Immune Regulation, Yielding Complete Tumor Regression in Mice.
PloS one
Foy SP,Sennino B,dela Cruz T,Cote JJ,Gordon EJ,Kemp F,Xavier V,Franzusoff A,Rountree RB,Mandl SJ
14-5982 was used in Flow cytometry/Cell sorting to support the clinical investigation of this triple therapy regimen, especially in cancer patients harboring PD-L1neg/low tumors unlikely to benefit from immune checkpoint blockade alone.
Thu Jul 14 00:00:00 EDT 2016
Exploring the induction of preproinsulin-specific Foxp3(+) CD4(+) Treg cells that inhibit CD8(+) T cell-mediated autoimmune diabetes by DNA vaccination.
Scientific reports
Stifter K,Schuster C,Schlosser M,Boehm BO,Schirmbeck R
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 14-5982-82) in Neutralization
Mon Jul 11 00:00:00 EDT 2016
Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission.
Immunity
Tian Y,Kuo CF,Akbari O,Ou JH
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 14-5982-82) in Flow Cytometry
Tue May 17 00:00:00 EDT 2016
Natural IgM Switches the Function of Lipopolysaccharide-Activated Murine Bone Marrow-Derived Dendritic Cells to a Regulatory Dendritic Cell That Suppresses Innate Inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Lobo PI,Schlegel KH,Bajwa A,Huang L,Kurmaeva E,Wang B,Ye H,Tedder TF,Kinsey GR,Okusa MD
14-5982 was used in Flow cytometry/Cell sorting to investigate how natural IgM anti-leukocyte Abs can switch BMDC to a regulatory phenotype despite the presence of LPS that ordinarily induces BMDC maturation.
Tue Dec 01 00:00:00 EST 2015
PD-1 or PD-L1 Blockade Restores Antitumor Efficacy Following SSX2 Epitope-Modified DNA Vaccine Immunization.
Cancer immunology research
Rekoske BT,Smith HA,Olson BM,Maricque BB,McNeel DG
14-5982 was used in Flow cytometry/Cell sorting to determine that vaccines aimed at eliciting effector CD8(+) T cells may have improved function when combined with PD-1 pathway inhibitors.
Sat Aug 01 00:00:00 EDT 2015
Dendritic Cell-Based Vaccines that Utilize Myeloid Rather than Plasmacytoid Cells Offer a Superior Survival Advantage in Malignant Glioma.
Journal of immunology (Baltimore, Md. : 1950)
Dey M,Chang AL,Miska J,Wainwright DA,Ahmed AU,Balyasnikova IV,Pytel P,Han Y,Tobias A,Zhang L,Qiao J,Lesniak MS
14-5982 was used in Flow cytometry/Cell sorting to compare the ability of myeloid and plasmacytoid dendritic cells to generate effective antiglioma immunity.
Wed Jul 01 00:00:00 EDT 2015
Sepsis-induced potentiation of peritoneal macrophage migration is mitigated by programmed cell death receptor-1 gene deficiency.
Journal of innate immunity
Ayala A,Elphick GF,Kim YS,Huang X,Carreira-Rosario A,Santos SC,Shubin NJ,Chen Y,Reichner J,Chung CS
14-5982 was used in Flow cytometry/Cell sorting to investigate the effect of programmed cell death receptor-1 in mediating aspects of innate macrophage immune dysfunction during sepsis.
Mon May 11 00:00:00 EDT 2015
Differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma.
European journal of immunology
McAlees JW,Lajoie S,Dienger K,Sproles AA,Richgels PK,Yang Y,Khodoun M,Azuma M,Yagita H,Fulkerson PC,Wills-Karp M,Lewkowich IP
14-5982 was used in Flow cytometry/Cell sorting to investigate the role of PD-1 family members in allergic asthma, showing differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis.
Wed Apr 01 00:00:00 EDT 2015
PD-1/PD-L1 blockade together with vaccine therapy facilitates effector T-cell infiltration into pancreatic tumors.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Soares KC,Rucki AA,Wu AA,Olino K,Xiao Q,Chai Y,Wamwea A,Bigelow E,Lutz E,Liu L,Yao S,Anders RA,Laheru D,Wolfgang CL,Edil BH,Schulick RD,Jaffee EM,Zheng L
14-5982 was used in Immunofluorescence to evaluate the use of single-agent checkpoint inhibitors for the treatment of pancreatic ductal adenocarcinoma.
Thu Jan 01 00:00:00 EST 2015
Requirement for interactions of natural killer T cells and myeloid-derived suppressor cells for transplantation tolerance.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Hongo D,Tang X,Baker J,Engleman EG,Strober S
14-5982 was used in Flow cytometry/Cell sorting to investigate the cellular and molecular mechanisms required for suitable immune tolerance for combined bone marrow and heart transplant acceptance in mice.
Sat Nov 01 00:00:00 EDT 2014
CTLA-4 and PD-L1 checkpoint blockade enhances oncolytic measles virus therapy.
Molecular therapy : the journal of the American Society of Gene Therapy
Engeland CE,Grossardt C,Veinalde R,Bossow S,Lutz D,Kaufmann JK,Shevchenko I,Umansky V,Nettelbeck DM,Weichert W,Jäger D,von Kalle C,Ungerechts G
14-5982 was used in in vivo experiments to suggest rapid translation of combining immune checkpoint modulation with oncolytic viruses into clinical application.
Sat Nov 01 00:00:00 EDT 2014
Glial cells suppress postencephalitic CD8+ T lymphocytes through PD-L1.
Glia
Schachtele SJ,Hu S,Sheng WS,Mutnal MB,Lokensgard JR
14-5982 was used in Functional assays to demonstrate that microglia and astrocytes control antiviral T-cell responses.
Wed Oct 01 00:00:00 EDT 2014
A crucial role for β2 integrins in podosome formation, dynamics and Toll-like-receptor-signaled disassembly in dendritic cells.
Journal of cell science
Gawden-Bone C,West MA,Morrison VL,Edgar AJ,McMillan SJ,Dill BD,Trost M,Prescott A,Fagerholm SC,Watts C
14-5982 was used in Flow cytometry/Cell sorting to assess the contribution of integrins to the function and maintenance of podosomes.
Wed Oct 01 00:00:00 EDT 2014
Programmed death-1 pathway in host tissues ameliorates Th17/Th1-mediated experimental chronic graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950)
Fujiwara H,Maeda Y,Kobayashi K,Nishimori H,Matsuoka K,Fujii N,Kondo E,Tanaka T,Chen L,Azuma M,Yagita H,Tanimoto M
14-5982 was used in Flow cytometry/Cell sorting to clarify that programed death-ligand 1 deficiency in host tissues, not hematopoietic cells, is associated with exacerbated chronic graft-versus-host disease.
Mon Sep 01 00:00:00 EDT 2014
Targeting immune co-stimulatory effects of PD-L1 and PD-L2 might represent an effective therapeutic strategy in stroke.
Frontiers in cellular neuroscience
Bodhankar S,Chen Y,Lapato A,Vandenbark AA,Murphy SJ,Offner H
14-5982 was used in Flow cytometry/Cell sorting to investigate PD-L1 and PD-L2 expressing cell types that affect T-cell activation post stroke, and how these could be targeted therapeutically.
Tue Aug 26 00:00:00 EDT 2014
Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection.
The Journal of experimental medicine
Penaloza-MacMaster P,Kamphorst AO,Wieland A,Araki K,Iyer SS,West EE,O'Mara L,Yang S,Konieczny BT,Sharpe AH,Freeman GJ,Rudensky AY,Ahmed R
14-5982 was used in Flow cytometry/Cell sorting to investigate a role for T reg cells in exhaustion of virus-specific CD8 T cells.
Mon Aug 25 00:00:00 EDT 2014
PD-L1 blockade attenuated sepsis-induced liver injury in a mouse cecal ligation and puncture model.
Mediators of inflammation
Zhu W,Bao R,Fan X,Tao T,Zhu J,Wang J,Li J,Bo L,Deng X
14-5982 was used in Immunohistochemistry to investigate the role of programmed death-ligand 1 in sepsis-induced liver injury using a mouse cecal ligation and puncture model.
Thu Jun 05 00:00:00 EDT 2014
Dietary supplementation with high doses of regular vitamin D3 safely reduces diabetes incidence in NOD mice when given early and long term.
Diabetes
Takiishi T,Ding L,Baeke F,Spagnuolo I,Sebastiani G,Laureys J,Verstuyf A,Carmeliet G,Dotta F,Van Belle TL,Gysemans CA,Mathieu C
14-5982 was used in Flow cytometry/Cell sorting to investigate the effect of vitamin D3 administration during different periods of life on diabetes prevention in NOD mice.
Sun Jun 01 00:00:00 EDT 2014
Adoptive transfer of cytokine-induced immunomodulatory adult microglia attenuates experimental autoimmune encephalomyelitis in DBA/1 mice.
Glia
Zhang XM,Lund H,Mia S,Parsa R,Harris RA
14-5982 was used in Flow cytometry/Cell sorting to demonstrate that adult immunosuppressive phenotype microglia therapy can alleviate established experimental autoimmune encephalomyelitis.
Thu May 01 00:00:00 EDT 2014
A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells.
Cancer research
Barsoum IB,Smallwood CA,Siemens DR,Graham CH
14-5982 was used in Flow cytometry/Cell sorting to investigate whether exposure of mouse and human tumour cells to hypoxia increases their resistance to T cell-mediated immunity.
Sat Feb 01 00:00:00 EST 2014
A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells.
Cancer research
Barsoum IB,Smallwood CA,Siemens DR,Graham CH
14-5982 was used in Flow cytometry/Cell sorting to investigate whether exposure of mouse and human tumour cells to hypoxia increases their resistance to T cell-mediated immunity.
Sat Feb 01 00:00:00 EST 2014
Local blockade of epithelial PDL-1 in the airways enhances T cell function and viral clearance during influenza virus infection.
Journal of virology
McNally B,Ye F,Willette M,Flaño E
14-5982 was used in Blocking experiments to examine the important immunoregulatory role of programmed death receptor 1 in the lung during viral infection.
Sun Dec 01 00:00:00 EST 2013
ICAM-1-dependent homotypic aggregates regulate CD8 T cell effector function and differentiation during T cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Zumwalde NA,Domae E,Mescher MF,Shimizu Y
14-5982 was used in Blocking experiments to demonstrate that during CD8 T cell activation, the T cell clustering mechanism allows for continued proliferation of T cells, and regulates CD8 T cell effector function and differentiation.
Tue Oct 01 00:00:00 EDT 2013
ICAM-1-dependent homotypic aggregates regulate CD8 T cell effector function and differentiation during T cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Zumwalde NA,Domae E,Mescher MF,Shimizu Y
14-5982 was used in Blocking experiments to demonstrate that during CD8 T cell activation, the T cell clustering mechanism allows for continued proliferation of T cells, and regulates CD8 T cell effector function and differentiation.
Tue Oct 01 00:00:00 EDT 2013
PD-L1 enhances CNS inflammation and infarct volume following experimental stroke in mice in opposition to PD-1.
Journal of neuroinflammation
Bodhankar S,Chen Y,Vandenbark AA,Murphy SJ,Offner H
14-5982 was used in Flow cytometry/Cell sorting to suggest that agents (for example antibodies) that can target and neutralise PD-L1/2 may have therapeutic potential for treatment of human stroke.
Mon Sep 09 00:00:00 EDT 2013
Donor CD8+ T cells prevent Toxoplasma gondii de-encystation but fail to rescue the exhausted endogenous CD8+ T cell population.
Infection and immunity
Bhadra R,Cobb DA,Khan IA
14-5982 was used in Flow cytometry/Cell sorting to determine if treatment with exogenous CD8+ T cells can rescue the endogenous population during Toxoplasma gondii infection.
Sun Sep 01 00:00:00 EDT 2013
Modulation of innate antigen-presenting cell function by pre-patent schistosome infection.
PLoS neglected tropical diseases
Ferragine CE,Walls CD,Davies SJ
14-5982 was used in Blocking experiments to show that CD11b+ cells exposed to prepatent schistosome infection are impaired in their ability to stimulate CD4+ T cells.
Wed Aug 28 00:00:00 EDT 2013
Programmed death receptor-1/programmed death receptor ligand-1 blockade after transient lymphodepletion to treat myeloma.
Journal of immunology (Baltimore, Md. : 1950)
Kearl TJ,Jing W,Gershan JA,Johnson BD
14-5982 was used in Flow cytometry/Cell sorting to demonstrate that a blockade of the PD-1/PD-L1 pathway yields positive antitumour results.
Sat Jun 01 00:00:00 EDT 2013
Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease.
The Journal of biological chemistry
McMahan RH,Wang XX,Cheng LL,Krisko T,Smith M,El Kasmi K,Pruzanski M,Adorini L,Golden-Mason L,Levi M,Rosen HR
14-5982 was used in Flow cytometry/Cell sorting to demonstrate that FXR/TGR5 activation coordinates the immune phenotype of monocytes and macrophages.
Fri Apr 26 00:00:00 EDT 2013
Adoptive transfer of immunomodulatory M2 macrophages prevents type 1 diabetes in NOD mice.
Diabetes
Parsa R,Andresen P,Gillett A,Mia S,Zhang XM,Mayans S,Holmberg D,Harris RA
14-5982 was used in Flow cytometry/Cell sorting to suggest that M2r macrophage therapy represents a novel intervention that stops ongoing autoimmune T1D and may have relevance in a clinical setting.
Thu Nov 01 00:00:00 EDT 2012
Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-β-induced differentiation of CD4+CD25+FoxP3+ Tregs from CD4+CD25-FoxP3- T cells.
Journal of leukocyte biology
Centuori SM,Trad M,LaCasse CJ,Alizadeh D,Larmonier CB,Hanke NT,Kartchner J,Janikashvili N,Bonnotte B,Larmonier N,Katsanis E
14-5982 was used in Blocking experiments to indicate that gr-MDSCs from TB hosts have the unanticipated ability to restrict immunosuppressive Tregs.
Thu Nov 01 00:00:00 EDT 2012
Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide.
PloS one
Siegert S,Huang HY,Yang CY,Scarpellino L,Carrie L,Essex S,Nelson PJ,Heikenwalder M,Acha-Orbea H,Buckley CD,Marsland BJ,Zehn D,Luther SA
14-5982 was used in Blocking experiments to highlight that fibroblastic reticular cells and dendritic cells cooperate in a negative feedback loop, attenuating T cell expansion during acute inflammation.
Mon Mar 26 00:00:00 EDT 2012
Farnesyltransferase inhibitor FTI-277 reduces mortality of septic mice along with improved bacterial clearance.
The Journal of pharmacology and experimental therapeutics
Yang W,Yamada M,Tamura Y,Chang K,Mao J,Zou L,Feng Y,Kida K,Scherrer-Crosbie M,Chao W,Ichinose F,Yu YM,Fischman AJ,Tompkins RG,Yao S,Kaneki M
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 14-5982-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2011
Retinal pericytes inhibit activated T cell proliferation.
Investigative ophthalmology & visual science
Tu Z,Li Y,Smith DS,Sheibani N,Huang S,Kern T,Lin F
14-5982 was used in Neutralization experiments to reveal a new function of retinal pericytes, and its regulation under hyperglycemic conditions.
Mon Nov 21 00:00:00 EST 2011
Retinal pericytes inhibit activated T cell proliferation.
Investigative ophthalmology & visual science
Tu Z,Li Y,Smith DS,Sheibani N,Huang S,Kern T,Lin F
14-5982 was used in Neutralization experiments to reveal a new function of retinal pericytes, and its regulation under hyperglycemic conditions.
Mon Nov 21 00:00:00 EST 2011
Ex vivo expanded hematopoietic stem cells overcome the MHC barrier in allogeneic transplantation.
Cell stem cell
Zheng J,Umikawa M,Zhang S,Huynh H,Silvany R,Chen BP,Chen L,Zhang CC
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 14-5982-82) in Flow Cytometry
Fri Aug 05 00:00:00 EDT 2011
Ex vivo expanded hematopoietic stem cells overcome the MHC barrier in allogeneic transplantation.
Cell stem cell
Zheng J,Umikawa M,Zhang S,Huynh H,Silvany R,Chen BP,Chen L,Zhang CC
Published figure using CD274 (PD-L1, B7-H1) monoclonal antibody (Product # 14-5982-82) in Flow Cytometry
Fri Aug 05 00:00:00 EDT 2011
CNS expression of B7-H1 regulates pro-inflammatory cytokine production and alters severity of Theiler's virus-induced demyelinating disease.
PloS one
Duncan DS,Miller SD
14-5982 was used in Flow cytometry/Cell sorting to suggest that CNS expression of B7-H1 regulates activation of TMEV-specific T-cells, which affects protection against TMEV-IDD.
Fri Apr 08 00:00:00 EDT 2011
Stromal cells' B7-1 is a key stimulatory molecule for interleukin-10 production by HOZOT, a multifunctional regulatory T-cell line.
Immunology and cell biology
Otani T,Tsuji-Takayama K,Okochi A,Yamamoto M,Takeuchi M,Yamasaki F,Nakamura S,Kibata M
14-5982 was used in Flow cytometry/Cell sorting to reveal that anti-mouse B7-1 Ab could effectively block IL-10 production, indicating a key role of the B7-1/CD28 pathway.
Tue Feb 01 00:00:00 EST 2011
Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/ PD-L1 pathway.
Aging cell
Lages CS,Lewkowich I,Sproles A,Wills-Karp M,Chougnet C
14-5982 was used in Flow cytometry/Cell sorting to suggest that blockade of the PD-1/PD-L1 is not likely to be efficient at restoring exhausted T-cell responses in aged hosts.
Fri Oct 01 00:00:00 EDT 2010
Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance.
Blood
Fukaya T,Takagi H,Sato Y,Sato K,Eizumi K,Taya H,Shin T,Chen L,Dong C,Azuma M,Yagita H,Malissen B,Sato K
14-5982 was used in Flow cytometry/Cell sorting to suggest that B7-H1 and B7-DC expressed on mesenteric lymph node DCs are essential for establishing oral tolerance.
Thu Sep 30 00:00:00 EDT 2010
Deficiency in B7-H1 (PD-L1)/PD-1 coinhibition triggers pancreatic beta-cell destruction by insulin-specific, murine CD8 T-cells.
Diabetes
Rajasalu T,Brosi H,Schuster C,Spyrantis A,Boehm BO,Chen L,Reimann J,Schirmbeck R
14-5982-82 was used in Inhibition Assays to study the effect of pancreatic beta cells costimulator B7.1 and coinhibitor B7-H1 imbalance as a trigger for primed auto immune destruction.
Sun Aug 01 00:00:00 EDT 2010
Alloantigen expression on non-hematopoietic cells reduces graft-versus-leukemia effects in mice.
The Journal of clinical investigation
Asakura S,Hashimoto D,Takashima S,Sugiyama H,Maeda Y,Akashi K,Tanimoto M,Teshima T
14-5982 was used in Immunohistochemistry to demonstrate that alloantigen expression on host epithelium drives donor T-cells into apoptosis and dysfunction during graft-versus-host disease.
Thu Jul 01 00:00:00 EDT 2010
IFN-gamma-receptor signaling ameliorates transplant vasculopathy through attenuation of CD8+ T-cell-mediated injury of vascular endothelial cells.
European journal of immunology
Bolinger B,Engeler D,Krebs P,Miller S,Firner S,Hoffmann M,Palmer DC,Restifo NP,Tian Y,Clavien PA,Ludewig B
14-5982 was used in Flow cytometry/Cell sorting to examine the interaction of CD8(+) T cells with antigen-presenting endothelial cells in vivo using a transgenic mouse heart transplantation model.
Mon Mar 01 00:00:00 EST 2010
Cryptococcus neoformans variants generated by phenotypic switching differ in virulence through effects on macrophage activation.
Infection and immunity
Guerrero A,Jain N,Wang X,Fries BC
14-5982 was used in Flow cytometry/Cell sorting to investigate the interaction between macrophages and cells from smooth-colony or mucoid-colony variants arising from phenotypic switching of Cryptococcus neoformans.
Mon Mar 01 00:00:00 EST 2010
Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation.
Nature immunology
Marks BR,Nowyhed HN,Choi JY,Poholek AC,Odegard JM,Flavell RA,Craft J
14-5982 was used in Flow cytometry/Cell sorting to demonstrate that T(H)-17 cells, like Treg cells, can be selected by self antigens in the thymus.
Thu Oct 01 00:00:00 EDT 2009
B7-H1 on hepatocytes facilitates priming of specific CD8 T cells but limits the specific recall of primed responses.
Gastroenterology
Wahl C,Bochtler P,Chen L,Schirmbeck R,Reimann J
14-5982 was used in Flow cytometry/Cell sorting to study the relationship between B7-H1 on hepatocytes and specific CD8 T cells.
Mon Sep 01 00:00:00 EDT 2008
A critical role of IFNgamma in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1.
Cell research
Sheng H,Wang Y,Jin Y,Zhang Q,Zhang Y,Wang L,Shen B,Yin S,Liu W,Cui L,Li N
Fri Aug 01 00:00:00 EDT 2008
Tumor-induced immune suppression of in vivo effector T-cell priming is mediated by the B7-H1/PD-1 axis and transforming growth factor beta.
Cancer research
Wei S,Shreiner AB,Takeshita N,Chen L,Zou W,Chang AE
14-5982 was used in Blocking experiments to show a role for the B7-H1/PD-1 axis and TGF-beta as synergistic suppressors in cancer tumor-draining lymph nodes.
Tue Jul 01 00:00:00 EDT 2008
Blockade of PD-1/B7-H1 interaction restores effector CD8+ T cell responses in a hepatitis C virus core murine model.
Journal of immunology (Baltimore, Md. : 1950)
Lukens JR,Cruise MW,Lassen MG,Hahn YS
14-5982 was used in Flow cytometry/Cell sorting to study the blockade of PD-1/B7-H1 interaction to restore effector CD8+ T cell responses in a hepatitis C virus core murine model.
Tue Apr 01 00:00:00 EDT 2008
Programmed death-1 (PD-1) defines a transient and dysfunctional oligoclonal T cell population in acute homeostatic proliferation.
The Journal of experimental medicine
Lin SJ,Peacock CD,Bahl K,Welsh RM
14-5982 was used in Flow cytometry/Cell sorting to suggest that PD-1 may play a negative regulatory role to control rapidly proliferating and potentially pathogenic autoreactive CD8+ T cells during homeostatic reconstitution of lymphopenic environments.
Mon Oct 01 00:00:00 EDT 2007
Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Magnus T,Schreiner B,Korn T,Jack C,Guo H,Antel J,Ifergan I,Chen L,Bischof F,Bar-Or A,Wiendl H
14-5982 was used in Neutralization experiments to investigate the role of B7 homolog 1 in regulating inflammation in the CNS.
Wed Mar 09 00:00:00 EST 2005
Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Magnus T,Schreiner B,Korn T,Jack C,Guo H,Antel J,Ifergan I,Chen L,Bischof F,Bar-Or A,Wiendl H
14-5982 was used in Neutralization experiments to investigate the role of B7 homolog 1 in regulating inflammation in the CNS.
Wed Mar 09 00:00:00 EST 2005
-Flow-20170216130641.jpg "CD274 (PD-L1, B7-H1) Antibody (14-5982-82) in Flow")
immunoglobulin receptor superfamily
