Invitrogen

CD275 (B7-H2) Polyclonal Antibody

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CD275 (B7-H2) Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of CD275 (B7-H2) in paraffin-embedded Human Endometrial cancer tissue. Samples were incubated with polyclonal antibody (Product # PA5-119204) at a dilution of 20 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG using a dilution of 2 µg/mL.

CD275 (B7-H2) Antibody in Western Blot (WB) — Western blot analysis of CD275 (B7-H2) in Lane 1: Wild-type Jurkat cell lysate; Lane 2: ICOSLG knockout Jurkat cell lysate . Samples were incubated with polyclonal antibody (Product # PA5-119204) at a dilution of 2 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG using a dilution of 0.2 µg/mL.

Product Details

PA5-119204

Applications	Tested Dilution	Publications
Western Blot (WB)	0.5-2 µg/mL	-
Immunohistochemistry (Paraffin) (IHC (P))	5-20 µg/mL	-
Immunocytochemistry (ICC/IF)	5-20 µg/mL	-

Product Specifications
Species Reactivity	Human
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Recombinant protein Inducible T-Cell Co Stimulator Ligand
Conjugate	Unconjugated
Form	Liquid
Concentration	500 µg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS with 50% glycerol
Contains	0.05% Proclin 300
Storage conditions	-20°C

Target Information

Inducible co-stimulator ligand (ICOSL) is a specific ligand on antigen-presenting cells and cells of the peripheral tissue that binds to the inducible co-stimulator receptor (ICOS). ICOS belongs to the CD28/CD152 receptor family that regulates T-cell activation and function. ICOSL is expressed on monocytes, dendritic cells and B cells and can be induced by inflammatory stimuli in peripheral tissue. Binding to ICOSL delivers a co-stimulatory signal for T cell proliferation and cytokine secretion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B7 homolog 2; B7 homologue 2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP-1; CD275; ICOS ligand; inducible T-cell co-stimulator ligand; transmembrane protein B7-H2 ICOS ligand

Gene Aliases: B7-H2; B7H2; B7RP-1; B7RP1; CD275; GL50; ICOS-L; ICOSL; ICOSLG; KIAA0653; LICOS

UniProt ID: (Human) O75144

Entrez Gene ID: (Human) 23308

Molecular Function: immunoglobulin receptor superfamily