Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade.
Srivastava S,Furlan SN,Jaeger-Ruckstuhl CA,Sarvothama M,Berger C,Smythe KS,Garrison SM,Specht JM,Lee SM,Amezquita RA,Voillet V,Muhunthan V,Yechan-Gunja S,Pillai SPS,Rader C,Houghton AM,Pierce RH,Gottardo R,Maloney DG,Riddell SR
12-2799-42 was used in Flow Cytometry to test strategies for enhancing efficacy of CAR-T cells targeting the tumor-associated antigen receptor tyrosine kinase-like orphan receptor 1 (ROR1) infiltrating tumors.
Mon Feb 08 00:00:00 EST 2021
CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice.
Cell reports. Medicine
Li N,Torres MB,Spetz MR,Wang R,Peng L,Tian M,Dower CM,Nguyen R,Sun M,Tai CH,de Val N,Cachau R,Wu X,Hewitt SM,Kaplan RN,Khan J,St Croix B,Thiele CJ,Ho M
12-2799-42 was used in Flow cytometry/Cell sorting to investigate if RNA-seq data can be exploited to help identify tumor-associated exons that can be targeted by CAR T cell therapies.
Tue Jun 15 00:00:00 EDT 2021
Harnessing Natural Killer Immunity in Metastatic SCLC.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
Best SA,Hess JB,Souza-Fonseca-Guimaraes F,Cursons J,Kersbergen A,Dong X,Rautela J,Hyslop SR,Ritchie ME,Davis MJ,Leong TL,Irving L,Steinfort D,Huntington ND,Sutherland KD
12-2799 was used in Flow cytometry/Cell sorting to investigate the immunophenotype of human SCLC tumours using multiple forms of analysis including flow cytometry using human samples.
Tue Sep 01 00:00:00 EDT 2020
Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9.
Liu L,Bi E,Ma X,Xiong W,Qian J,Ye L,Su P,Wang Q,Xiao L,Yang M,Lu Y,Yi Q
12-2799 was used in Flow cytometry/Cell sorting to show that, through a Th9-culture condition, polarized and expanded human CAR-T cells have an enhanced antitumor activity.
Thu Nov 19 00:00:00 EST 2020
Circulating Exosomes Inhibit B Cell Proliferation and Activity.
Schroeder JC,Puntigam L,Hofmann L,Jeske SS,Beccard IJ,Doescher J,Laban S,Hoffmann TK,Brunner C,Theodoraki MN,Schuler PJ
12-2799 was used in Flow cytometry/Cell sorting to isolate and analyse peripheral B cells by flow cytometry to understand the effects of exosomes on B cells.
Wed Jul 29 00:00:00 EDT 2020
A facile technology for the high-throughput sequencing of the paired VH:VL and TCRβ:TCRα repertoires.
Tanno H,McDaniel JR,Stevens CA,Voss WN,Li J,Durrett R,Lee J,Gollihar J,Tanno Y,Delidakis G,Pothukuchy A,Ellefson JW,Goronzy JJ,Maynard JA,Ellington AD,Ippolito GC,Georgiou G
12-2799 was used in Flow cytometry/Cell sorting to determine the VH:VL or TCRb:a repertoire with high accuracy and throughput.
Wed Apr 01 00:00:00 EDT 2020
Th2 Biased Immunity With Altered B Cell Profiles in Circulation of Patients With Sporotrichosis Caused by Sporothrix globosa.
Frontiers in immunology
Zu J,Yao L,Song Y,Cui Y,Guan M,Chen R,Zhen Y,Li S
12-2799 was used in Flow cytometry/Cell sorting to shed light on the potential involvement of peripheral T and B cell immunity against this mycotic infection.
Mon May 31 00:00:00 EDT 2021
Separation of plasma-derived exosomes into CD3(+) and CD3(-) fractions allows for association of immune cell and tumour cell markers with disease activity in HNSCC patients.
Clinical and experimental immunology
Theodoraki MN,Hoffmann TK,Whiteside TL
12-2799 was used in Flow cytometry/Cell sorting to investigate whether tumour- or T cell-derived exosomes in head and neck squamous cell carcinoma patients' plasma are immunosuppressive and impact upon disease activity.
Fri Jun 01 00:00:00 EDT 2018
Phenotypic and Functional Profiles of Antigen-Specific CD4+ and CD8+ T Cells Associated With Infection Control in Patients With Cutaneous Leishmaniasis.
Frontiers in cellular and infection microbiology
Egui A,Ledesma D,Pérez-Antón E,Montoya A,Gómez I,Robledo SM,Infante JJ,Vélez ID,López MC,Thomas MC
12-2799 was used in Flow cytometry/Cell sorting to suggest a possible exhaustion process of CD8+ T cells associated with the evolution of Leishmania infection.
Wed Sep 18 00:00:00 EDT 2019
YY1 Upregulates Checkpoint Receptors and Downregulates Type I Cytokines in Exhausted, Chronically Stimulated Human T Cells.
Balkhi MY,Wittmann G,Xiong F,Junghans RP
12-2799 was used in Flow cytometry/Cell sorting to elucidate a Yin Yang-1-centred mechanism for diverse cellular components correlated with exhaustion.
Fri Apr 27 00:00:00 EDT 2018
Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles.
Ricklefs FL,Alayo Q,Krenzlin H,Mahmoud AB,Speranza MC,Nakashima H,Hayes JL,Lee K,Balaj L,Passaro C,Rooj AK,Krasemann S,Carter BS,Chen CC,Steed T,Treiber J,Rodig S,Yang K,Nakano I,Lee H,Weissleder R,Breakefield XO,Godlewski J,Westphal M,Lamszus K,Freeman GJ,Bronisz A,Lawler SE,Chiocca EA
12-2799 was used in Flow cytometry/Cell sorting to investigate whether glioblastoma extracellular vesicles are important mediators of immunosuppression and whether programmed death ligand-1 could play a role.
Thu Mar 01 00:00:00 EST 2018
The influence of chemotherapy on adenosine-producing B cells in patients with head and neck squamous cell carcinoma.
Ziebart A,Huber U,Jeske S,Laban S,Doescher J,Hoffmann TK,Brunner C,Jackson EK,Schuler PJ
12-2799 was used in Flow cytometry/Cell sorting to study the influence of chemotherapy on the function of regulatory B cells.
Fri Jan 19 00:00:00 EST 2018
Overcoming Target Driven Fratricide for T Cell Therapy.
Frontiers in immunology
Breman E,Demoulin B,Agaugué S,Mauën S,Michaux A,Springuel L,Houssa J,Huberty F,Jacques-Hespel C,Marchand C,Marijsse J,Nguyen T,Ramelot N,Violle B,Daro D,De Waele P,Gilham DE,Steenwinckel V
12-2799 was used in Flow cytometry/Cell sorting to demonstrate that target-driven chimeric antigen receptor T cell fratricide can be overcome through targeted inhibition of NKG2D expression or inhibition of enzyme function.
Mon Oct 07 00:00:00 EDT 2019
Cytomegalovirus infection in HIV-infected and uninfected individuals is characterized by circulating regulatory T cells of unconstrained antigenic specificity.
Tovar-Salazar A,Weinberg A
12-2799 was used in Flow cytometry/Cell sorting to indicate that CMV-seropositive individuals have circulating Tregs that inhibit cell-mediated immune responses to CMV and other antigens and may be contribute to an immune-suppressive effect of CMV infection.
Fri Oct 06 00:00:00 EDT 2017
Tumor-derived exosomes regulate expression of immune function-related genes in human T cell subsets.
Muller L,Mitsuhashi M,Simms P,Gooding WE,Whiteside TL
12-2799 was used in Flow cytometry/Cell sorting to study the regulation of immune function-related genes in human T cell subsets through tumor-derived exosomes.
Thu Feb 04 00:00:00 EST 2016
Inhibitory Receptor Expression on CD8+ T Cells Is Linked to Functional Responses against Trypanosoma cruzi Antigens in Chronic Chagasic Patients.
Journal of immunology (Baltimore, Md. : 1950)
Lasso P,Mateus J,Pavía P,Rosas F,Roa N,Thomas MC,López MC,González JM,Puerta CJ,Cuéllar A
12-2799 was used in Flow cytometry/Cell sorting to suggest that during Chagas disease, CD8(+) T cells undergo gradual loss of function, impaired cytokine production and increased inhibitory receptor coexpression.
Thu Oct 15 00:00:00 EDT 2015
Lipopolysaccharide Increases Immune Activation and Alters T Cell Homeostasis in SHIVB'WHU Chronically Infected Chinese Rhesus Macaque.
Journal of immunology research
Zhang GH,Wu RD,Zheng HY,Zhang XL,Zhang MX,Tian RR,Liu GM,Pang W,Zheng YT
12-2799 was used in Flow cytometry/Cell sorting to investigate the mechanisms behind lipopolysaccharide disruption of immune responses in Chinese rhesus macaques.
Wed Sep 07 00:00:00 EDT 2016
Circulating CXCR5⁺CD4⁺ T Follicular-Like Helper Cell and Memory B Cell Responses to Human Papillomavirus Vaccines.
Matsui K,Adelsberger JW,Kemp TJ,Baseler MW,Ledgerwood JE,Pinto LA
12-2799 was used in Flow cytometry/Cell sorting to identify different subsets of CXCR5+CD4+ Tfh-like cells in response to highly immunogenic and efficacious vaccines for HPV.
Tue May 24 00:00:00 EDT 2016
Exosomes isolated from plasma of glioma patients enrolled in a vaccination trial reflect antitumor immune activity and might predict survival.
Muller L,Muller-Haegele S,Mitsuhashi M,Gooding W,Okada H,Whiteside TL
12-2799 was used in Flow cytometry/Cell sorting to show exosomes from the plasma of glioma patients from a vaccination trial reflect antitumour immune activity which may predict survival.
Mon Jun 01 00:00:00 EDT 2015
Rapid Proliferation and Differentiation of a Subset of Circulating IgM Memory B Cells to a CpG/Cytokine Stimulus In Vitro.
Vásquez C,Franco MA,Angel J
12-2799 was used in Flow cytometry/Cell sorting to compare the phenotype and in vitro functional response of various immune cells in response to CpG and a cytokine cocktail.
Thu Jun 02 00:00:00 EDT 2016
Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist.
Thaventhiran T,Alhumeed N,Yeang HX,Sethu S,Downey JS,Alghanem AF,Olayanju A,Smith EL,Cross MJ,Webb SD,Williams DP,Bristow A,Ball C,Stebbings R,Sathish JG
12-2799 was used in Flow cytometry/Cell sorting to understand the underlying molecular mechanisms of T-cell activation in response to TGN1412-like CD28 superagonist, showing that failure to upregulate the inhibitory PD-1 cell surface receptor is part of this mechanism.
Mon Aug 24 00:00:00 EDT 2015
Changes in immune cell populations in the periphery and liver of GBV-B-infected and convalescent tamarins (Saguinus labiatus).
Hood SP,Mee ET,Perkins H,Bowen O,Dale JM,Almond NM,Karayiannis P,Bright H,Berry NJ,Rose NJ
12-2799 was used in Flow cytometry/Cell sorting to characterise changes in lymphocyte populations in tamarins with an acute GBV-B infection.
Wed Jan 22 00:00:00 EST 2014
Comparison of influenza and SIV specific CD8 T cell responses in macaques.
Jegaskanda S,Reece JC,De Rose R,Stambas J,Sullivan L,Brooks AG,Kent SJ,Sexton A
12-2799 was used in Flow cytometry/Cell sorting to suggest that strategies to maintain a more functional CD8(+) T-cell response, profile may assist in controlling HIV disease.
Mon Jul 09 00:00:00 EDT 2012
Increased frequency of regulatory T cells accompanies increased immune activation in rectal mucosae of HIV-positive noncontrollers.
Journal of virology
Shaw JM,Hunt PW,Critchfield JW,McConnell DH,Garcia JC,Pollard RB,Somsouk M,Deeks SG,Shacklett BL
12-2799 was used in Flow cytometry/Cell sorting to investigate the role of Tregs in persistent HIV infection, showing that an increased frequency of Tregs accompanies increased immune activation in HIV-positive noncontrollers.
Tue Nov 01 00:00:00 EDT 2011
Phagocytosis, a potential mechanism for myeloid-derived suppressor cell regulation of CD8+ T cell function mediated through programmed cell death-1 and programmed cell death-1 ligand interaction.
Journal of immunology (Baltimore, Md. : 1950)
Kim YJ,Park SJ,Broxmeyer HE
12-2799 was used in Flow cytometry/Cell sorting to identify a potential mechanism by which IFN-γ-producing CD8(+) T cells are tolerised after type 1 immune responses to chronic virus or tumour.
Thu Sep 01 00:00:00 EDT 2011