Evidence of SARS-CoV-2 infection in postmortem lung, kidney, and liver samples, revealing cellular targets involved in COVID-19 pathogenesis.
Archives of virology
Falcón-Cama V,Montero-González T,Acosta-Medina EF,Guillen-Nieto G,Berlanga-Acosta J,Fernández-Ortega C,Alfonso-Falcón A,Gilva-Rodríguez N,López-Nocedo L,Cremata-García D,Matos-Terrero M,Pentón-Rol G,Valdés I,Oramas-Díaz L,Suarez-Batista A,Noa-Romero E,Cruz-Sui O,Sánchez D,Borrego-Díaz AI,Valdés-Carreras JE,Vizcaino A,Suárez-Alba J,Valdés-Véliz R,Bergado G,González MA,Hernandez T,Alvarez-Arzola R,Ramírez-Suárez AC,Casillas-Casanova D,Lemos-Pérez G,Blanco-Águila OR,Díaz A,González Y,Bequet-Romero M,Marín-Prida J,Hernández-Perera JC,Del Rosario-Cruz L,Marin-Díaz AP,González-Bravo M,Borrajero I,Acosta-Rivero N
17-2799-42 was used in flow cytometry to identify the SARS-CoV-2 nucleocapsid (NC) in a variety of cells, colocalizing with mitochondrial proteins, lipid droplets (LDs), and key host proteins that have been implicated in inflammation, tissue repair, and the SARS-CoV-2 life cycle (vimentin, NLRP3, fibronectin, LC3B, DDX3X, and PPARγ), pointing to vimentin and LDs as platforms involved not only in the viral life cycle but also in inflammation and pathogenesis.
Sun Feb 26 00:00:00 EST 2023
The ubiquitin ligase Peli1 inhibits ICOS and thereby Tfh-mediated immunity.
Cellular & molecular immunology
Huang X,Hao S,Liu J,Huang Y,Liu M,Xiao C,Wang Y,Pei S,Yu T,Xu J,Wang H,Dai D,Su X,Xiao Y
17-2799-42 was used in Flow Cytometry to elucidate the molecular mechanisms regulating T follicular helper cells.
Thu Apr 01 00:00:00 EDT 2021
Cancer-secreted exosomal miR-1468-5p promotes tumor immune escape via the immunosuppressive reprogramming of lymphatic vessels.
Molecular therapy : the journal of the American Society of Gene Therapy
Zhou C,Wei W,Ma J,Yang Y,Liang L,Zhang Y,Wang Z,Chen X,Huang L,Wang W,Wu S
17-2799-42 was used in Flow Cytometry to investigate how lymphatic endothelial cells are immunosuppressed to allow cancer immune evasion.
Wed Apr 07 00:00:00 EDT 2021
Exosome-derived miR-142-5p remodels lymphatic vessels and induces IDO to promote immune privilege in the tumour microenvironment.
Cell death and differentiation
Zhou C,Zhang Y,Yan R,Huang L,Mellor AL,Yang Y,Chen X,Wei W,Wu X,Yu L,Liang L,Zhang D,Wu S,Wang W
17-2799 was used in Flow cytometry/Cell sorting to suggest that LECs act as an integral component of the immune checkpoint(s) in the TME and may serve as a potential new target for CSCC diagnosis and treatment.
Mon Feb 01 00:00:00 EST 2021
Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy.
Cell reports. Medicine
Müller TR,Jarosch S,Hammel M,Leube J,Grassmann S,Bernard B,Effenberger M,Andrä I,Chaudhry MZ,Käuferle T,Malo A,Cicin-Sain L,Steinberger P,Feuchtinger T,Protzer U,Schumann K,Neuenhahn M,Schober K,Busch DH
17-2799-42 was used in Flow Cytometry to conclude that increased T cell product homogeneity after targeted TCR gene editing correlates with predictable in vivo T cell responses, which represents a crucial aspect for clinical application in adoptive T cell immunotherapy.
Tue Aug 17 00:00:00 EDT 2021
Ex vivo modelling of PD-1/PD-L1 immune checkpoint blockade under acute, chronic, and exhaustion-like conditions of T-cell stimulation.
Roberts A,Bentley L,Tang T,Stewart F,Pallini C,Juvvanapudi J,Wallace GR,Cooper AJ,Scott A,Thickett D,Lugg ST,Bancroft H,Hemming B,Ferris C,Langman G,Robinson A,Chapman J,Naidu B,Pinkney T,Taylor GS,Brock K,Stamataki Z,Brady CA,Curnow SJ,Gordon J,Qureshi O,Barnes NM
17-2799-42 was used in Flow Cytometry to identify a number of in vitro assays with response profiles that mimic features of dissociated cell populations from primary tumours, which represent disease-relevant functional assays for the screening of immune checkpoint inhibitors, which may support patient stratification of those likely to respond to immuno-oncology therapies.
Wed Feb 17 00:00:00 EST 2021
Bcl-2 Enhances Chimeric Antigen Receptor T Cell Persistence by Reducing Activation-Induced Apoptosis.
Wang H,Han P,Qi X,Li F,Li M,Fan L,Zhang H,Zhang X,Yang X
17-2799-42 was used in Flow Cytometry to provide proof of concept evidence for a new strategy to optimize the function of CAR-T cells against lymphoma.
Fri Jan 08 00:00:00 EST 2021
Filgotinib suppresses HIV-1-driven gene transcription by inhibiting HIV-1 splicing and T cell activation.
The Journal of clinical investigation
Yeh YJ,Jenike KM,Calvi RM,Chiarella J,Hoh R,Deeks SG,Ho YC
17-2799 was used in Flow cytometry/Cell sorting to identify HIV-1-suppressing agents that can inhibit HIV-1 reactivation and reduce HIV-1-induced immune activation.
Tue Sep 01 00:00:00 EDT 2020
Circulating CCR7loPD-1hi Follicular Helper T Cells Indicate Disease Activity and Glandular Inflammation in Patients with Primary Sjögren's Syndrome.
Kim JW,Lee J,Hong SM,Lee J,Cho ML,Park SH
17-2799 was used in Flow cytometry/Cell sorting to investigate the presence of Tfh and Tfr cells in the blood of pSS patients and their signification of disease activity, glandular inflammation or autoantibody responses.
Thu Aug 01 00:00:00 EDT 2019
Comprehensive Cell Surface Antigen Analysis Identifies Transferrin Receptor Protein-1 (CD71) as a Negative Selection Marker for Human Neuronal Cells.
Stem cells (Dayton, Ohio)
Menon V,Thomas R,Elgueta C,Horl M,Osborn T,Hallett PJ,Bartos M,Isacson O,Pruszak J
Tue Oct 01 00:00:00 EDT 2019
Reduced Chronic Lymphocyte Activation following Interferon Alpha Blockade during the Acute Phase of Simian Immunodeficiency Virus Infection in Rhesus Macaques.
Journal of virology
Carnathan D,Lawson B,Yu J,Patel K,Billingsley JM,Tharp GK,Delmas OM,Dawoud R,Wilkinson P,Nicolette C,Cameron MJ,Sekaly RP,Bosinger SE,Silvestri G,Vanderford TH
17-2799 was used in Flow cytometry/Cell sorting to determine the role of interferon alpha in simian immunodeficiency virus pathogenesis in rhesus macaques.
Tue May 01 00:00:00 EDT 2018
Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition.
The Journal of clinical investigation
Cherkassky L,Morello A,Villena-Vargas J,Feng Y,Dimitrov DS,Jones DR,Sadelain M,Adusumilli PS
17-2799 was used in Flow cytometry/Cell sorting to provide mechanistic insights into human chimeric antigen receptor T-cell exhaustion in solid tumors.
Mon Aug 01 00:00:00 EDT 2016
Depressive symptoms post hip fracture in older adults are associated with phenotypic and functional alterations in T cells.
Immunity & ageing : I & A
Duggal NA,Upton J,Phillips AC,Hampson P,Lord JM
17-2799 was used in Flow cytometry/Cell sorting to investigate the synergistic effects of hip fracture physical trauma and psychological depressive symptoms on the aged immune system.
Wed Jan 28 00:00:00 EST 2015
Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Kim EJ,Kwun J,Gibby AC,Hong JJ,Farris AB,Iwakoshi NN,Villinger F,Kirk AD,Knechtle SJ
17-2799 was used in Flow cytometry/Cell sorting to investigate methods to block antibody-mediated rejection of organ transplant, showing that belatacept and 2C10R4 selectively suppresses the humoral response via regulating Tfh cells and prevents antibody-mediated rejection.
Wed Jan 01 00:00:00 EST 2014
HIV-1 Tat protein induces PD-L1 (B7-H1) expression on dendritic cells through tumor necrosis factor alpha- and toll-like receptor 4-mediated mechanisms.
Journal of virology
Planès R,BenMohamed L,Leghmari K,Delobel P,Izopet J,Bahraoui E
17-2799 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which HIV-1 induces upregulation of coinhibitory molecules, showing that the HIV-1 Tat protein induces PD-L1 expression on dendritic cells.
Sun Jun 01 00:00:00 EDT 2014
Strength of PD-1 signaling differentially affects T-cell effector functions.
Proceedings of the National Academy of Sciences of the United States of America
Wei F,Zhong S,Ma Z,Kong H,Medvec A,Ahmed R,Freeman GJ,Krogsgaard M,Riley JL
17-2799 was used in Flow cytometry/Cell sorting to provide insight into the role of PD-1 expression in enforcing T-cell exhaustion and the therapeutic potential of PD-1 blockade.
Tue Jul 02 00:00:00 EDT 2013