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|Tested species reactivity||Human , Primate|
|Host / Isotype||Mouse / IgG1|
|Immunogen||DC220.127.116.11 murine T cell hybridoma transfected with human CD28 cDNA.|
|Storage buffer||PBS, pH 7.4|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||2-8 ug/ml|
|Functional Assay (FN)||Assay Dependent|
|Immunocytochemistry (ICC)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Endotoxin level is less than 0.01 EU/ug of the protein, as determined by the LAL test.
CD28 is the critical T cell costimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its costimulation role CD28 functions in preventing T cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CD28 antigen; MGC138290; Tp44