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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Clone||M2AB, 17D8, BHPT-1|
|Immunogen||human thymocytes, human peripheral blood T lymphocytes and peripheral blood monocytes from a rheumatoid arthritis patient|
|Conjugate||PE , PE-Cyanine5|
|Storage buffer||PBS with 0.2% carrier protein|
|Contains||0.08% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody is a monoclonal mixture of FITC-conjugated CD3 (clone M2AB, isotype IgG1), PE-conjugated CD8 (clone 17D8, isotype IgG1) and Cy5-PE-conjugated CD45 (clone BHPT-1, isotype IgG1).
T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.. CD8 molecule is composed of two chains termed alpha and beta. CD8 is found on a T cell subset of normal cytotoxic / suppressor cells which make up approximately 20 to 35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer cells, 80% of thymocytes, on a subpopulation of 30% of peripheral blood null cells and 15 to 30% of bone marrow cells.. CD45 Leukocyte Common Antigen (LCA) belongs to the family of at least four isoforms of membrane glycoproteins (220, 205, 190, 180 kDa) expressed on hematopoietic cell lines but absent on non-hematopoietic cell lines, normal and malignant, non-hematopoietic tissues. The intracellular portion of these molecules have protein phosphatase activity and are involved in regulation of transmembrane signals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
B220; c polypeptide; CD3 antigen, delta subunit; CD3 delta; CD3 epsilon; CD3-epsilon; CD3d; CD3d antigen, delta polypeptide (TiT3 complex); CD3d molecule, delta (CD3-TCR complex); CD3e; CD3e antigen; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3g; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); CD45; CD45 antigen; CD45R; CD8; CD8 antigen, alpha polypeptide (p32); CD8 antigen, beta polypeptide 1 (p37); CD8a; CD8alpha; CD8b; CD8beta; epsilon polypeptide TiT3 complex; epsilon subunit of T3; FLJ18683; GP180; L-CA; LCA; Leu-2; Leu2 T-lymphocyte antigen; Leukocyte common antigen; LY5; MAL; OKT3, delta chain; OKT8 T-cell antigen; protein tyrosine phosphatase; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; PTPRC; receptor type; Receptor-type tyrosine-protein phosphatase C; T cell co-receptor; T lymphocyte surface glycoprotein beta chain; T-cell antigen Leu2; T-cell antigen receptor complex; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell receptor T3 delta chain; T-cell receptor T3 gamma chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 beta chain; T-lymphocyte differentiation antigen T8/Leu-2; T200; T200 glycoprotein; T200 leukocyte common antigen; T3E; T8 T-cell antigen; TCRE
B220; CD3-DELTA; CD3-GAMMA; CD3D; CD3E; CD3G; CD45; CD45R; CD8; CD8A; CD8B; CD8B1; GP180; IMD17; IMD18; IMD19; L-CA; LCA; LEU2; LY3; LY5; LYT3; MAL; p32; P37; PTPRC; T200; T3D; T3E; T3G; TCRE