|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Leucocytes from a patient suffering from a LGL type leukaemia.|
|Storage buffer||PBS, pH 7.4|
|Contains||15mM sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1-10 ug/ml|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Not Applicable||Not Cited||
Delayed Microvascular Shear Adaptation in Pulmonary Arterial Hypertension. Role of Platelet Endothelial Cell Adhesion Molecule-1 Cleavage.
MA1-19199 was used in western blot to assess the role of platelet endothelial cell adhesion molecule-1 cleavage in delayed microvascular shear adaptation in pulmonary arterial hypertension
|Szulcek R,Happé CM,Rol N,Fontijn RD,Dickhoff C,Hartemink KJ,Grünberg K,Tu L,Timens W,Nossent GD,Paul MA,Leyen TA,Horrevoets AJ,de Man FS,Guignabert C,Yu PB,Vonk-Noordegraaf A,van Nieuw Amerongen GP,Bogaard HJ||American journal of respiratory and critical care medicine (193:1410)||2016|
Spatial patterning of endothelial cells and vascular network formation using ultrasound standing wave fields.
MA1-19199 was used in immunohistochemistry to demonstrate that the spatial pattern of endothelial cells within three-dimensional collagen gels can be controlled by design of acoustic parameters of the sound field.
|Garvin KA,Dalecki D,Yousefhussien M,Helguera M,Hocking DC||The Journal of the Acoustical Society of America (134:1483)||2013|
Vascularization of three-dimensional collagen hydrogels using ultrasound standing wave fields.
MA1-19199 was used in immunocytochemistry to use ultrasound standing wave field technology to vascularize 3-D, collagen-based hydrogels in vitro.
|Garvin KA,Dalecki D,Hocking DC||Ultrasound in medicine and biology (37:1853)||2011|
Efficient antiproliferative and antiangiogenic effects on human ovarian cancer growth by gene transfer of attenuated mutants of Shiga-like toxin I.
MA1-19199 was used in immunohistochemistry - paraffin section to determine the effects of anticancer and antiangiogenesis of Shiga-like toxin 1(W203F and R170H) in cancer gene therapy
|Wei F,Cao S,Ren X,Liu H,Yu J,Li H,Hao X||International journal of gynecological cancer : official journal of the International Gynecological Cancer Society (18:677)||2008|