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|Tested species reactivity||Human|
|Published species reactivity||Dog, Rat, Hamster, Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to C-terminus of mouse CD31 protein|
|Storage buffer||PBS, pH 7.6, with 0.2% BSA|
|Contains||15mM sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:25-1:50|
|Western Blot (WB)||1-3 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-16301 targets CD31 in IHC (P) applications and shows reactivity with Human samples.
The PA5-16301 immunogen is synthetic peptide corresponding to C-terminus of mouse CD31 protein.
CD31 is a glycoprotein expressed on endothelial cells and in platelets. It is known to be involved in cell signaling and cell adhesion. Antibody to CD31 is of value in the study of benign and malignant vascular tumors. Staining for CD31 has also been used to measure angiogenesis, which reportedly predicts tumor recurrence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity.
PA5-16301 was used in immunohistochemistry - paraffin section to use a mouse xenograft model to investigate the impact of sub-clonal heterogeneity on tumor phenotypes
|Marusyk A,Tabassum DP,Altrock PM,Almendro V,Michor F,Polyak K||Nature (514:54)||2014|
Double-antiangiogenic protein DAAP targeting vascular endothelial growth factor A and angiopoietins attenuates collagen-induced arthritis.
PA5-16301 was used in immunohistochemistry to study the mechanisms underlying the beneficial effects of recombinant DAAP in a murine model of collagen-induced arthritis
|Hah YS,Koh YJ,Lim HS,Kim HO,Cheon YH,Noh HS,Jang KY,Lee SY,Lee GM,Koh GY,Lee SI||Arthritis research & therapy (15:null)||2014|
A diaCEST MRI approach for monitoring liposomal accumulation in tumors.
PA5-16301 was used in immunohistochemistry to use diaCREST liposomes to study the uptake of liposomes by tumors using MRI analysis
|Chan KW,Yu T,Qiao Y,Liu Q,Yang M,Patel H,Liu G,Kinzler KW,Vogelstein B,Bulte JW,van Zijl PC,Hanes J,Zhou S,McMahon MT||Journal of controlled release : official journal of the Controlled Release Society (180:51)||2014|
Potential application of in vivo imaging of impaired lymphatic duct to evaluate the severity of pressure ulcer in mouse model.
PA5-16301 was used in immunohistochemistry to use an in vivo imaging system in a murine model to study defective lymphatic drainage as a marker for the severity of pressure ulcer
|Kasuya A,Sakabe J,Tokura Y||Scientific reports (4:null)||2014|
Therapy with siRNA for Vegf-c but not for Vegf-d suppresses wide-spectrum organ metastasis in an immunocompetent xenograft model of metastatic mammary cancer.
PA5-16301 was used in immunohistochemistry to study the involvement of VEGF-C but not of VEGF-D in wide-spectrum organ metastasis in a murine model of breast cancer using siRNA-mediated knock down
|Shibata MA,Shibata E,Morimoto J,Harada-Shiba M||Anticancer research (33:4237)||2013|
Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice.
PA5-16301 was used in immunohistochemistry to study the roles of calpain-1 and calpain-2 in murine aortic aneurysms induced by angiotensin II
|Subramanian V,Moorleghen JJ,Balakrishnan A,Howatt DA,Chishti AH,Uchida HA||PloS one (8:null)||2013|
Role of p53, Bax, p21, and DNA-PKcs in radiation sensitivity of HCT-116 cells and xenografts.
PA5-16301 was used in immunohistochemistry to study the sensitivity of colorectal cancer cells and xenografts to radiation and the potential roles of p53, Bax and the DNA-PK catalytic subunit
|Huerta S,Gao X,Dineen S,Kapur P,Saha D,Meyer J||Surgery (154:143)||2013|
Analysis of constant tissue remodeling in Syrian hamster Harderian gland: intra-tubular and inter-tubular syncytial masses.
PA5-16301 was used in immunohistochemistry to study the mechanisms of inter-tubular holocrine secretion in the Harderian gland of the Syrian hamster
|Coto-Montes A,García-Macía M,Caballero B,Sierra V,Rodríguez-Colunga MJ,Reiter RJ,Vega-Naredo I||Journal of anatomy (222:558)||2013|
Epidermal growth factor facilitates melanoma lymph node metastasis by influencing tumor lymphangiogenesis.
PA5-16301 was used in immunohistochemistry to study the role of lymphangiogenesis in the mechanism by which EGF promotes lymph node metastasis of melanoma
|Bracher A,Cardona AS,Tauber S,Fink AM,Steiner A,Pehamberger H,Niederleithner H,Petzelbauer P,Gröger M,Loewe R||The Journal of investigative dermatology (133:230)||2013|
Mammary cancer gene therapy targeting lymphangiogenesis: VEGF-C siRNA and soluble VEGF receptor-2, a splicing variant.
PA5-16301 was used in immunohistochemistry to review the therapautic effects on breast cancer lymphangiogenesis of gene therapy targeting either VEGF-C knockdown or expression of soluble VEGFR-2
|Shibata MA,Ambati J,Shibata E,Yoshidome K,Harada-Shiba M||Medical molecular morphology (45:179)||2012|
Effects of angiogenesis inhibition by spironolactone on isolated vas deferens contractility in an experimental varicocele model in rats.
PA5-16301 was used in immunohistochemistry to study the contractility of isolated vas deferens in a rat model of varicocele treated with the angiogenesis inhibitor spironolactone
|Köse MG,Erdem ŞR,Peșkircioğlu ÇL,Çaylak B||Urology (80:816)||2012|
Photodynamic induced uptake of liposomal doxorubicin to rat lung tumors parallels tumor vascular density.
PA5-16301 was used in immunohistochemistry to study the effects of photodynamic therapy on the uptake of liposomal doxorubicin by different types of tumors resident on rat lungs
|Wang Y,Gonzalez M,Cheng C,Haouala A,Krueger T,Peters S,Decosterd LA,van den Bergh H,Perentes JY,Ris HB,Letovanec I,Debefve E||Lasers in surgery and medicine (44:318)||2012|
The alarmin IL-33 is a notch target in quiescent endothelial cells.
PA5-16301 was used in immunocytochemistry to study the role of Notch signaling in regulating IL-33 expression in quiescent endothelial cells
|Sundlisaeter E,Edelmann RJ,Hol J,Sponheim J,Küchler AM,Weiss M,Udalova IA,Midwood KS,Kasprzycka M,Haraldsen G||The American journal of pathology (181:1099)||2012|
adhesion molecule; CD31 antigen; CD31/EndoCAM; endoCAM; platelet endothelial cell adhesion molecule; platelet/endothelial cell adhesion molecule 1
CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1; PECAM-1; PECAM1