|Tested species reactivity||Hamster, Mouse|
|Published species reactivity||Rat, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 508-536 amino acids from the C-terminal region of mouse CD31|
|Purification||Antigen affinity chromatography|
|Contains||0.09% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Modulates BDKRB2 activation. Induces susceptibility to atherosclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Endothelial LSP1 Modulates Extravascular Neutrophil Chemotaxis by Regulating Nonhematopoietic Vascular PECAM-1 Expression.
PA5-24411 was used in immunohistochemistry to study cell-specific function of LSP1 during leukocyte recruitment
|Hossain M,Qadri SM,Xu N,Su Y,Cayabyab FS,Heit B,Liu L||Journal of immunology (Baltimore, Md. : 1950) (195:2408)||2015|
The effect of metanephros transplantation on blood pressure in anephric rats with induced acute hypotension.
PA5-24411 was used in immunohistochemistry to study the role of metanephros transplantation in maintaining blood pressure in hypotensive anephric rats
|Yokote S,Yokoo T,Matsumoto K,Utsunomiya Y,Kawamura T,Hosoya T||Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (27:3449)||2012|
Adipose tissue explants and MDCK cells reciprocally regulate their morphogenesis in coculture.
PA5-24411 was used in immunohistochemistry to study the reciprocal regulation of morphogenesis in co-cultures of adipose tissue explants and MDCK cells
|Udo K,Aoki S,Uchihashi K,Kawasaki M,Matsunobu A,Tokuda Y,Ootani A,Toda S,Uozumi J||Kidney international (78:60)||2010|
Combination of vesicular stomatitis virus matrix protein gene therapy with low-dose cisplatin improves therapeutic efficacy against murine melonoma.
PA5-24411 was used in immunohistochemistry to study the therepeutic efficacy of vesicular stomatitis virus matrix protein gene therapy plus low-dose cisplatin against murine melonoma
|Luo S,Chen P,Luo ZC,Zhang P,Sun P,Shi W,Li ZY,Zhang XL,Wang LQ,Chen X,Wei YQ,Wen YJ||Cancer science (101:1219)||2010|
CD11c(hi) dendritic cells regulate the re-establishment of vascular quiescence and stabilization after immune stimulation of lymph nodes.
PA5-24411 was used in immunohistochemistry to study the role of CD11c(hi)-expressing dendritic cells in the regulation of quiescence and stabilization of new vasculature following immune stimulation of lymph nodes
|Tzeng TC,Chyou S,Tian S,Webster B,Carpenter AC,Guaiquil VH,Lu TT||Journal of immunology (Baltimore, Md. : 1950) (184:4247)||2010|
Antimetastatic effect of suicide gene therapy for mouse mammary cancers requires T-cell-mediated immune responses.
PA5-24411 was used in immunohistochemistry to study the role of T-cell-mediated immune responses in the antimetastatic effect of suicide gene therapy of mouse mammary cancers
|Shibata MA,Morimoto J,Akamatsu K,Otsuki Y||Medical molecular morphology (41:34)||2008|
A new organotypic culture of adipose tissue fragments maintains viable mature adipocytes for a long term, together with development of immature adipocytes and mesenchymal stem cell-like cells.
PA5-24411 was used in immunocytochemistry and immunohistochemistry to develop a new culture system for studying multiple cell types within adipose tissue
|Sonoda E,Aoki S,Uchihashi K,Soejima H,Kanaji S,Izuhara K,Satoh S,Fujitani N,Sugihara H,Toda S||Endocrinology (149:4794)||2008|