Positive Samples: Mouse spleen, Rat liver; Cellular Location: Cell membrane, Single-pass type I membrane protein
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: CD32; CDw32; Fc fragment of IgG, low affinity II, receptor for (CD32); Fc fragment of IgG, low affinity IIb, receptor (CD32); Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc gamma receptor IIB; Fc gamma RIIB; Fc receptor, IgG, low affinity IIb; FC-gamma RII; Fc-gamma RII-b; Fc-gamma-RII; Fc-gamma-RIIb; FC?RIIb; FcgammaRIIB; FcRII; fcRII-b; IgG Fc receptor II beta; IgG Fc receptor II-b; Low affinity immunoglobulin gamma Fc region receptor II; Low affinity immunoglobulin gamma Fc region receptor II-b; Ly-17; Lymphocyte antigen 17
Gene Aliases: AI528646; CD32; CD32B; F630109E10Rik; Fc[g]RII; FCG2; FcgammaRIIB2; FCGR2; Fcgr2a; FCGR2B; FcgRII; Fcr-2; Fcr-3; FCRII; IGFR2; Ly-17; Ly-m20; LyM-1
Molecular Function: cell adhesion molecule