Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Immunogen sequence: SMFLLLKEGR SSHVQRGYGK VQAEFPLGPV TTAHRGTYRC FGSYNNHAWS FPSEPVKLLV TGDIENTSLA PEDPTFPDTW GTYLLTTETG LQKDHALWDH TAQNLLRMGL AFLVLVALVW FLVEDWLSRK RTRERASRAS TWEGRRRLNT QTL; Positive Samples: A-549, Mouse spleen, Mouse thymus, Rat spleen, Rat lung; Cellular Location: Cell membrane, Single-pass type I membrane protein
NKp46 (CD335, NCR1, ) is a cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. NKp46 consists of two Ig-like domains assembled to leukocyte immunoglobulin-like (LIR) and killer inhibitory receptors (KIR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Activating receptor 1; CD335; Lymphocyte antigen 94; Lymphocyte antigen 94 homolog; lymphocyte antigen 94 homolog (activating NK-receptor; lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46); mAR-1; MAR1 (mouse activating receptor 1); mNKp46; Natural cytotoxicity triggering receptor 1; Natural killer cell p46-related protein; NK cell-activating receptor; NK receptor KILR-1; NK-p46; NK-p46); NKACTR; rAR-1; rat-activating receptor 1
Gene Aliases: Ar1; CD335; KILR-1; Kilr1; LY94; NCR1; NK-p46; NKP46
UniProt ID: (Human) O76036, (Rat) Q9Z0H5, (Mouse) Q8C567
Entrez Gene ID: (Human) 9437, (Rat) 117547, (Mouse) 17086
Molecular Function:
cytokine receptor
defense/immunity protein
immunoglobulin receptor superfamily
membrane-bound signaling molecule
receptor
signaling molecule
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support
