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|Tested species reactivity||Human, Non-human primate|
|Published species reactivity||Rabbit, Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human endothelial vesicles|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:50|
|Immunohistochemistry (Frozen) (IHC (F))||Assay-dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
|Western Blot (WB)||Assay-dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody detects CD34 in human, Cynomolgus monkey and Rhesus monkey samples.
IHC was performed using methanol-fixed cells. Do not perform antigen retrieval prior to IHC staining. This target has a predicted molecular weight of 40 kDa.
CD34 is possibly a adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative role in signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Superficial soft tissue biphasic synovial sarcoma with apocrine differentiation in the glandular component: a report of two cases.
MA5-18091 was used in immunohistochemistry to report on two cases of superficial soft tissue biphasic synovial sarcoma presenting with apocrine differentiation
|Shelekhova KV,Calonje E,Grossmann P,Kacerovska D,Koudela K,Mirka H,Michal M,Kazakov DV||The American Journal of dermatopathology (36:847)||2014|
Use of platelet-rich plasma solution applied with composite chondrocutaneous graft technique: an experimental study in rabbit model.
MA5-18091 was used in immunohistochemistry to study the mechanisms underlying the beneficial effects of using platelet-rich plasma in composite chondrocutaneous graft procedures
|Sevim KZ,Yazar M,Irmak F,Tekkeşin MS,Yildiz K,Sirvan SS||Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons (72:1407)||2014|
Recruitment of CD34(+) fibroblasts in tumor-associated reactive stroma: the reactive microvasculature hypothesis.
MA5-18091 was used in immunohistochemistry to study the recruitment to tumor-associated reactive stroma of a novel CD34(+)/vimentin(+) dual-positive fibroblast
|San Martin R,Barron DA,Tuxhorn JA,Ressler SJ,Hayward SW,Shen X,Laucirica R,Wheeler TM,Gutierrez C,Ayala GE,Ittmann M,Rowley DR||The American journal of pathology (184:1860)||2014|
Immunohistochemical study of Ki67, CD34 and p53 expression in human tooth buds.
MA5-18091 was used in immunohistochemistry to study the developmental time course of Ki67, CD34 and p53 expression in human tooth buds
|Muica Nagy-Bota MC,Pap Z,Denes L,Ghizdavăţ A,Brînzaniuc K,Lup Coşarcă AS,Chibelean Cireş-Mărginean M,Păcurar M,Pávai Z||Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie (55:43)||2014|
Rhabdoid morphology in gastrointestinal stromal tumours (GISTs) is associated with PDGFRA mutations but does not imply aggressive behaviour.
MA5-18091 was used in immunohistochemistry to study the association of mutations in PDGF-Ralpha with gastrointestinal stromal tumors of rhabdoid morphology
|Schaefer IM,Ströbel P,Cameron S,Beham A,Otto C,Schildhaus HU,Agaimy A||Histopathology (64:421)||2014|
Histopathological, immunophenotypic and clinical particularities and evolution of a case of hepatosplenic T-cell lymphoma in transformation to leukemia.
MA5-18091 was used in immunohistochemistry to report on a case of hepatosplenic T-cell lymphoma with leukemic transformation
|Benedek Lázár E,Köpeczi JB,Tunyogi AB,Kakucs E,Horváth E,Turcu M,Benedek I||Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie (54:1135)||2014|
Molecular analysis of the KIT gene in gastrointestinal stromal tumors with novel mutations.
MA5-18091 was used in immunohistochemistry to study the clinicopathology of gastrointestinal stromal tumors with novel KIT mutations
|Calibasi G,Baskin Y,Alyuruk H,Cavas L,Oztop I,Sagol O,Atila K,Ellidokuz H,Yilmaz U||Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry (22:37)||2014|
The prognostic impact of MGMT expression on low-grade gangliogliomas: a clinicopathological and immunohistochemical study.
MA5-18091 was used in immunohistochemistry to study the prognostic value of the immunohistochemical expression of MGMT in low-grade ganglioglioma
|Chang IW,Hsu CT,Lin JW,Hung CH||Folia neuropathologica / Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences (51:275)||2013|
Contribution of DOG1 expression to the diagnosis of gastrointestinal stromal tumors.
MA5-18091 was used in immunohistochemistry to study the diagnostic value of the immunohistochemical expression of DOG1 in gastrointestinal stromal tumors
|Kara T,Serinsoz E,Arpaci RB,Gubur O,Orekici G,Ata A,Colak T,Arican A||Pathology, research and practice (209:413)||2013|
Primary breast cancer stem-like cells metastasise to bone, switch phenotype and acquire a bone tropism signature.
MA5-18091 was used in immunohistochemistry to study the bone metastasis of primary breast cancer stem-like cells and the bone-tropism signature displayed by cells isolated from bone
|D'Amico L,Patanè S,Grange C,Bussolati B,Isella C,Fontani L,Godio L,Cilli M,D'Amelio P,Isaia G,Medico E,Ferracini R,Roato I||British journal of cancer (108:2525)||2013|
A rare malignant tumor of scalp in a 3-month-old Taiwanese infancy: case report of primitive myxoid mesenchymal tumor of infancy with molecular study.
MA5-18091 was used in immunohistochemistry to report on a case of primitive myxoid mesenchymal tumor of infancy
|Su TC,Hwang MJ,Li CF,Wang SC,Lee CH,Chen CJ||Medical molecular morphology (46:109)||2013|
Incidental Epstein-Barr virus associated atypical lymphoid proliferation arising in a left atrial myxoma: a case of long survival without any postsurgical treatment and review of the literature.
MA5-18091 was used in immunohistochemistry to report on a case of left atrial cardiac myxoma with incidental atypical B-cell lymphoid proliferation
|Bartoloni G,Pucci A,Giorlandino A,Berretta M,Mignosa C,Italia F,Carbone A,Canzonieri V||Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology (22:e5)||2013|
The decrease of mineralcorticoid receptor drives angiogenic pathways in colorectal cancer.
MA5-18091 was used in immunohistochemistry to study the regulation of angiogenesis in colorectal cancer by the mineralocorticoid receptor
|Tiberio L,Nascimbeni R,Villanacci V,Casella C,Fra A,Vezzoli V,Furlan L,Meyer G,Parrinello G,Baroni MD,Salerni B,Schiaffonati L||PloS one (8:null)||2013|
Aberrant expression of CD133 in non-small cell lung cancer and its relationship to vasculogenic mimicry.
MA5-18091 was used in immunohistochemistry to study the prognostic value of CD133 and vasculogenic mimicry in patients with non-small cell lung cancer
|Wu S,Yu L,Wang D,Zhou L,Cheng Z,Chai D,Ma L,Tao Y||BMC cancer (12:null)||2012|
Functional consequences of prolactin signalling in endothelial cells: a potential link with angiogenesis in pathophysiology?
MA5-18091 was used in immunohistochemistry to investigate the functions of prolactin in endothelial cells and its involvement in pathological angiogenesis.
|Reuwer AQ,Nowak-Sliwinska P,Mans LA,van der Loos CM,von der Thüsen JH,Twickler MT,Spek CA,Goffin V,Griffioen AW,Borensztajn KS||Journal of cellular and molecular medicine (16:2035)||2012|
Expression of maspin in non-small cell lung cancer and its relationship to vasculogenic mimicry.
MA5-18091 was used in immunohistochemistry to study the significance of maspin expression in non-small cell lung cancer
|Wu S,Yu L,Cheng Z,Song W,Zhou L,Tao Y||Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban (32:346)||2012|
Castration resistant prostate cancer is associated with increased blood vessel stabilization and elevated levels of VEGF and Ang-2.
MA5-18091 was used in immunohistochemistry to study blood vessel stabilization and the expression of pro-angiogenic VEGF and Ang-2 in castration-resistant prostate cancer
|Tomić TT,Gustavsson H,Wang W,Jennbacken K,Welén K,Damber JE||The Prostate (72:705)||2012|
Mesenchymal stem cells in infantile hemangioma reside in the perivascular region.
MA5-18091 was used in immunocytochemistry to test if MSCs in hemangioma also reside in the perivascular region
|Yuan SM,Chen RL,Shen WM,Chen HN,Zhou XJ||Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society (15:5)||2012|
CD34 antigen; hematopoietic progenitor cell antigen CD34; Mucosialin; RP11-328D5.2