CD34 is a highly glycosylated monomeric 111-115 kDa surface protein, which is present on many stem cell populations. It is a well established stem cell marker, though its expression on human hematopoietic stem cells is reversible. CD34 probably serves as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions.
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Protein Aliases: CD34 antigen; hematopoietic progenitor cell antigen CD34; Mucosialin; RP11-328D5.2
Gene Aliases: RP11-328D5.2
UniProt ID: (Human) P28906
Entrez Gene ID: (Human) 947