Product References
B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation.
Nature communications
Stoler-Barak L,Harris E,Peres A,Hezroni H,Kuka M,Di Lucia P,Grenov A,Gurwicz N,Kupervaser M,Yip BH,Iannacone M,Yaari G,Crispino JD,Shulman Z
56-0381-82 was used in Flow cytometry/Cell sorting to demonstrate DYRK1A-mediated biological mechanisms of B cell immune responses that may be used for therapeutic manipulation in antibody-mediated autoimmunity.
Thu Mar 16 00:00:00 EDT 2023
CD4 T cell epitope abundance in ferritin core potentiates responses to hemagglutinin nanoparticle vaccines.
NPJ vaccines
Nelson SA,Richards KA,Glover MA,Chaves FA,Crank MC,Graham BS,Kanekiyo M,Sant AJ
56-0381-82 was used in Flow cytometry/Cell sorting to show that availability of helper CD4 T cell epitopes may be a key additional mechanism that underlies the enhanced immunogenicity of ferritin-based HA-Fe-nanoparticle vaccines.
Wed Oct 26 00:00:00 EDT 2022
Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches.
Cell
Guilliams M,Bonnardel J,Haest B,Vanderborght B,Wagner C,Remmerie A,Bujko A,Martens L,Thoné T,Browaeys R,De Ponti FF,Vanneste B,Zwicker C,Svedberg FR,Vanhalewyn T,Gonçalves A,Lippens S,Devriendt B,Cox E,Ferrero G,Wittamer V,Willaert A,Kaptein SJF,Neyts J,Dallmeier K,Geldhof P,Casaert S,Deplancke B,Ten Dijke P,Hoorens A,Vanlander A,Berrevoet F,Van Nieuwenhove Y,Saeys Y,Saelens W,Van Vlierberghe H,Devisscher L,Scott CL
56-0381-82 was used in Flow cytometry/Cell sorting to demonstrate that LAMs are induced by local lipid exposure, leading to their induction in steatotic regions of the murine and human liver, while Kupffer cell development crucially depends on their cross-talk with hepatic stellate cells via the evolutionarily conserved ALK1-BMP9/10 axis.
Thu Jan 20 00:00:00 EST 2022
Alphavirus-Driven Interferon Gamma (IFNg) Expression Inhibits Tumor Growth in Orthotopic 4T1 Breast Cancer Model.
Vaccines
Trofimova O,Korotkaja K,Skrastina D,Jansons J,Spunde K,Isaguliants M,Zajakina A
Published figure using CD38 monoclonal antibody (Product # 56-0381-82) in Flow Cytometry
Wed Oct 27 00:00:00 EDT 2021
Pro-inflammatory immunity supports fibrosis advancement in epidermolysis bullosa: intervention with Ang-(1-7).
EMBO molecular medicine
Bernasconi R,Thriene K,Romero-Fernández E,Gretzmeier C,Kühl T,Maler M,Nauroy P,Kleiser S,Rühl-Muth AC,Stumpe M,Kiritsi D,Martin SF,Hinz B,Bruckner-Tuderman L,Dengjel J,Nyström A
Published figure using CD38 monoclonal antibody (Product # 56-0381-82) in Flow Cytometry
Thu Oct 07 00:00:00 EDT 2021
Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity.
Cell reports
Szodoray P,Andersen TK,Heinzelbecker J,Imbery JF,Huszthy PC,Stanford SM,Bogen B,Landsverk OB,Bottini N,Tveita A,Munthe LA,Nakken B
56-0381-82 was used in Flow Cytometry to show that high CD45 phosphatase activity in memory B cells enhances B cell receptor signaling and is essential for their effective antibody-secreting cell differentiation.
Tue Aug 10 00:00:00 EDT 2021
Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs.
Cell reports
Ortega-Molina A,Lebrero-Fernández C,Sanz A,Deleyto-Seldas N,Plata-Gómez AB,Menéndez C,Graña-Castro O,Caleiras E,Efeyan A
56-0381-82 was used in Flow Cytometry to support the efficacy and safety of moderate inhibition of nutrient signaling against pathological B cells.
Tue Jul 13 00:00:00 EDT 2021
Overcoming PD-1 Inhibitor Resistance with a Monoclonal Antibody to Secreted Frizzled-Related Protein 2 in Metastatic Osteosarcoma.
Cancers
Nasarre P,Garcia DI,Siegel JB,Bonilla IV,Mukherjee R,Hilliard E,Chakraborty P,Nasarre C,Yustein JT,Lang M,Jaffa AA,Mehrotra S,Klauber-DeMore N
Published figure using CD38 monoclonal antibody (Product # 56-0381-82) in Flow Cytometry
Sun May 30 00:00:00 EDT 2021
Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies.
Cell reports
Seydoux E,Wan YH,Feng J,Wall A,Aljedani S,Homad LJ,MacCamy AJ,Weidle C,Gray MD,Brumage L,Taylor JJ,Pancera M,Stamatatos L,McGuire AT
56-0381-82 was used in Flow Cytometry to characterize a panel of anti-idiotypic monoclonal antibodies (ai-mAbs) raised against inferred-germline (iGL) VRC01-class antibodies.
Tue May 04 00:00:00 EDT 2021
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
Nature immunology
Rivas MA,Meydan C,Chin CR,Challman MF,Kim D,Bhinder B,Kloetgen A,Viny AD,Teater MR,McNally DR,Doane AS,Béguelin W,Fernández MTC,Shen H,Wang X,Levine RL,Chen Z,Tsirigos A,Elemento O,Mason CE,Melnick AM
Published figure using CD38 monoclonal antibody (Product # 56-0381-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2021
Multiplexed CRISPR/CAS9-mediated engineering of pre-clinical mouse models bearing native human B cell receptors.
The EMBO journal
Wang X,Ray R,Kratochvil S,Melzi E,Lin YC,Giguere S,Xu L,Warner J,Cheon D,Liguori A,Groschel B,Phelps N,Adachi Y,Tingle R,Wu L,Crotty S,Kirsch KH,Nair U,Schief WR,Batista FD
56-0381 was used in Flow cytometry/Cell sorting to report a one-step CRISPR/Cas9 KI methodology to combine the insertion of human germline immunoglobulin heavy and light chains at their endogenous loci in mice.
Fri Jan 15 00:00:00 EST 2021
Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19.
Cell
Rodda LB,Netland J,Shehata L,Pruner KB,Morawski PA,Thouvenel CD,Takehara KK,Eggenberger J,Hemann EA,Waterman HR,Fahning ML,Chen Y,Hale M,Rathe J,Stokes C,Wrenn S,Fiala B,Carter L,Hamerman JA,King NP,Gale M,Campbell DJ,Rawlings DJ,Pepper M
56-0381 was used in Flow cytometry/Cell sorting to perform a longitudinal assessment of individuals recovered from mild COVID-19 to determine whether they develop and sustain multifaceted SARS-CoV-2-specific immunological memory.
Thu Jan 07 00:00:00 EST 2021
Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19.
Cell
Rodda LB,Netland J,Shehata L,Pruner KB,Morawski PA,Thouvenel CD,Takehara KK,Eggenberger J,Hemann EA,Waterman HR,Fahning ML,Chen Y,Hale M,Rathe J,Stokes C,Wrenn S,Fiala B,Carter L,Hamerman JA,King NP,Gale M,Campbell DJ,Rawlings DJ,Pepper M
56-0381 was used in Flow cytometry/Cell sorting to perform a longitudinal assessment of individuals recovered from mild COVID-19 to determine whether they develop and sustain multifaceted SARS-CoV-2-specific immunological memory.
Thu Jan 07 00:00:00 EST 2021
Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2.
Cell
Walls AC,Fiala B,Schäfer A,Wrenn S,Pham MN,Murphy M,Tse LV,Shehata L,O'Connor MA,Chen C,Navarro MJ,Miranda MC,Pettie D,Ravichandran R,Kraft JC,Ogohara C,Palser A,Chalk S,Lee EC,Guerriero K,Kepl E,Chow CM,Sydeman C,Hodge EA,Brown B,Fuller JT,Dinnon KH,Gralinski LE,Leist SR,Gully KL,Lewis TB,Guttman M,Chu HY,Lee KK,Fuller DH,Baric RS,Kellam P,Carter L,Pepper M,Sheahan TP,Veesler D,King NP
56-0381 was used in Flow cytometry/Cell sorting to develop a structure-based design of non-particle immunogens to elicit protective antibody responses against SARS-CoV-2 in mice.
Wed Nov 25 00:00:00 EST 2020
A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice.
Immunity
Laczkó D,Hogan MJ,Toulmin SA,Hicks P,Lederer K,Gaudette BT,Castaño D,Amanat F,Muramatsu H,Oguin TH,Ojha A,Zhang L,Mu Z,Parks R,Manzoni TB,Roper B,Strohmeier S,Tombácz I,Arwood L,Nachbagauer R,Karikó K,Greenhouse J,Pessaint L,Porto M,Putman-Taylor T,Strasbaugh A,Campbell TA,Lin PJC,Tam YK,Sempowski GD,Farzan M,Choe H,Saunders KO,Haynes BF,Andersen H,Eisenlohr LC,Weissman D,Krammer F,Bates P,Allman D,Locci M,Pardi N
56-0381 was used in Flow cytometry/Cell sorting to study the immunogenicity of lipid nanoparticle-encapsulated, nucleoside-modified mRNA vaccines against SARS-CoV-2 in mice.
Tue Oct 13 00:00:00 EDT 2020
Antibody Feedback Limits the Expansion of B Cell Responses to Malaria Vaccination but Drives Diversification of the Humoral Response.
Cell host & microbe
McNamara HA,Idris AH,Sutton HJ,Vistein R,Flynn BJ,Cai Y,Wiehe K,Lyke KE,Chatterjee D,Kc N,Chakravarty S,Lee Sim BK,Hoffman SL,Bonsignori M,Seder RA,Cockburn IA
56-0381 was used in Flow cytometry/Cell sorting to suggest that antibody feedback drives the diversification of immune responses and that vaccination for malaria will require targeting multiple antigens.
Wed Oct 07 00:00:00 EDT 2020
Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver.
Immunity
Remmerie A,Martens L,Thoné T,Castoldi A,Seurinck R,Pavie B,Roels J,Vanneste B,De Prijck S,Vanhockerhout M,Binte Abdul Latib M,Devisscher L,Hoorens A,Bonnardel J,Vandamme N,Kremer A,Borghgraef P,Van Vlierberghe H,Lippens S,Pearce E,Saeys Y,Scott CL
56-0381 was used in Flow cytometry/Cell sorting to highlight considerable heterogeneity within the macrophage pool and suggest a need for more specific macrophage targeting strategies in metabolic-associated fatty liver disease (MAFLD).
Tue Sep 15 00:00:00 EDT 2020
Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2.
bioRxiv : the preprint server for biology
Walls AC,Fiala B,Schäfer A,Wrenn S,Pham MN,Murphy M,Tse LV,Shehata L,O'Connor MA,Chen C,Navarro MJ,Miranda MC,Pettie D,Ravichandran R,Kraft JC,Ogohara C,Palser A,Chalk S,Lee EC,Kepl E,Chow CM,Sydeman C,Hodge EA,Brown B,Fuller JT,Dinnon KH,Gralinski LE,Leist SR,Gully KL,Lewis TB,Guttman M,Chu HY,Lee KK,Fuller DH,Baric RS,Kellam P,Carter L,Pepper M,Sheahan TP,Veesler D,King NP
56-0381-82 was used in Flow Cytometry to highlight the utility of robust antigen display platforms for inducing potent neutralizing antibody responses and launch cGMP manufacturing efforts to advance the lead RBD nanoparticle vaccine into the clinic.
Wed Aug 12 00:00:00 EDT 2020
Evaluation of B Cell Proliferation in vivo by EdU Incorporation Assay.
Bio-protocol
Biram A,Shulman Z
56-0381-82 was used in Flow Cytometry to provide details for EdU incorporation measurement by flow cytometry of B cells in different compartments within the gut associated lymphoid organs.
Tue May 05 00:00:00 EDT 2020
Nucleoside-modified mRNA vaccination partially overcomes maternal antibody inhibition of de novo immune responses in mice.
Science translational medicine
Willis E,Pardi N,Parkhouse K,Mui BL,Tam YK,Weissman D,Hensley SE
56-0381-82 was used in Flow Cytometry to demonstrate that influenza virus-specific maternal antibodies inhibited de novo antibody responses in mouse pups elicited by influenza virus infection or administration of conventional influenza vaccines.
Wed Jan 08 00:00:00 EST 2020
Overcoming Steric Restrictions of VRC01 HIV-1 Neutralizing Antibodies through Immunization.
Cell reports
Parks KR,MacCamy AJ,Trichka J,Gray M,Weidle C,Borst AJ,Khechaduri A,Takushi B,Agrawal P,Guenaga J,Wyatt RT,Coler R,Seaman M,LaBranche C,Montefiori DC,Veesler D,Pancera M,McGuire A,Stamatatos L
56-0381 was used in Flow cytometry/Cell sorting to report on a two-step immunization scheme that leads to the maturation of VRC01-like antibodies capable of accommodating the N276 glycan and displaying autologous tier 2 neutralizing activities.
Tue Dec 03 00:00:00 EST 2019
CHK1 dosage in germinal center B cells controls humoral immunity.
Cell death and differentiation
Schoeler K,Jakic B,Heppke J,Soratroi C,Aufschnaiter A,Hermann-Kleiter N,Villunger A,Labi V
Published figure using CD38 monoclonal antibody (Product # 56-0381-82) in Flow Cytometry
Sun Dec 01 00:00:00 EST 2019
Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche.
Immunity
Bonnardel J,T'Jonck W,Gaublomme D,Browaeys R,Scott CL,Martens L,Vanneste B,De Prijck S,Nedospasov SA,Kremer A,Van Hamme E,Borghgraef P,Toussaint W,De Bleser P,Mannaerts I,Beschin A,van Grunsven LA,Lambrecht BN,Taghon T,Lippens S,Elewaut D,Saeys Y,Guilliams M
56-0381-82 was used in Flow Cytometry to show that the Kupffer cell niche is composed of stellate cells, hepatocytes, and endothelial cells that together imprint the liver-specific macrophage identity.
Tue Oct 15 00:00:00 EDT 2019
EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop.
Nature communications
Béguelin W,Rivas MA,Calvo Fernández MT,Teater M,Purwada A,Redmond D,Shen H,Challman MF,Elemento O,Singh A,Melnick AM
Published figure using CD38 monoclonal antibody (Product # 56-0381-82) in Flow Cytometry
Thu Oct 12 00:00:00 EDT 2017
IL-4 Haploinsufficiency Specifically Impairs IgE Responses against Allergens in Mice.
Journal of immunology (Baltimore, Md. : 1950)
Robinson MJ,Prout M,Mearns H,Kyle R,Camberis M,Forbes-Blom EE,Paul WE,Allen CD,Le Gros G
56-0381 was used in Flow cytometry/Cell sorting to identify that mice with only one intact Il4 gene copy are significantly impaired in their ability to make specific IgE responses against allergens, whereas IgG1 responses to allergens remain unaffected.
Wed Mar 01 00:00:00 EST 2017
mTOR has distinct functions in generating versus sustaining humoral immunity.
The Journal of clinical investigation
Jones DD,Gaudette BT,Wilmore JR,Chernova I,Bortnick A,Weiss BM,Allman D
56038182 was used in flow cytometry to investigate the role of mTOR in plasma cell differentiation and antibody production in RAPTOR deficient cells.
Tue Nov 01 00:00:00 EDT 2016
Sequencing and cloning of antigen-specific antibodies from mouse memory B cells.
Nature protocols
von Boehmer L,Liu C,Ackerman S,Gitlin AD,Wang Q,Gazumyan A,Nussenzweig MC
56-0381-82 was used in Flow cytometry/Cell sorting to sequence and clone the variable antibody region of single antigen-specific mouse memory B cells for antibody production.
Sat Oct 01 00:00:00 EDT 2016
Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization.
Nature communications
Bemark M,Hazanov H,Strömberg A,Komban R,Holmqvist J,Köster S,Mattsson J,Sikora P,Mehr R,Lycke NY
Published figure using CD38 monoclonal antibody (Product # 56-0381-82) in Flow Cytometry
Tue Sep 06 00:00:00 EDT 2016
BILL-cadherin/cadherin-17 contributes to the survival of memory B cells.
PloS one
Funakoshi S,Shimizu T,Numata O,Ato M,Melchers F,Ohnishi K
56-0381 was used in Flow cytometry/Cell sorting to study how CDH17 plays a role in the long-term survival of memory B cells via an 'MBC niche'.
Wed Sep 16 00:00:00 EDT 2015
Virus-encoded microRNAs facilitate gammaherpesvirus latency and pathogenesis in vivo.
mBio
Feldman ER,Kara M,Coleman CB,Grau KR,Oko LM,Krueger BJ,Renne R,van Dyk LF,Tibbetts SA
56-0381 was used in Flow cytometry/Cell sorting to elucidate the contribution of gammaherpesvirus miRNAs to viral replication, survival, and pathogenesis in vivo.
Tue May 27 00:00:00 EDT 2014
Investigating the role for IL-21 in rabies virus vaccine-induced immunity.
PLoS neglected tropical diseases
Dorfmeier CL,Tzvetkov EP,Gatt A,McGettigan JP
56-0381 was used in Flow cytometry/Cell sorting to study the effects of knocking out IL-21 on the development of vaccine-induced immunity against rabies.
Wed Aug 28 00:00:00 EDT 2013
A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.
The Journal of clinical investigation
Dai X,James RG,Habib T,Singh S,Jackson S,Khim S,Moon RT,Liggitt D,Wolf-Yadlin A,Buckner JH,Rawlings DJ
Published figure using CD38 monoclonal antibody (Product # 56-0381-82) in Flow Cytometry
Wed May 01 00:00:00 EDT 2013
Divergent transcriptional programming of class-specific B cell memory by T-bet and RORα.
Nature immunology
Wang NS,McHeyzer-Williams LJ,Okitsu SL,Burris TP,Reiner SL,McHeyzer-Williams MG
56-0381 was used in Flow cytometry/Cell sorting to demonstrate that memory B cell subsets diverge across antibody class through differences in the effects of major transcriptional regulators.
Sun May 06 00:00:00 EDT 2012
EBI2 operates independently of but in cooperation with CXCR5 and CCR7 to direct B cell migration and organization in follicles and the germinal center.
Journal of immunology (Baltimore, Md. : 1950)
Gatto D,Wood K,Brink R
56-0381 was used in Flow cytometry/Cell sorting to show EBI2-mediated chemotaxis provides a third dimension to B cell migration that balances and integrates with the inputs from CXCR5 and CCR7 to determine B cell positioning.
Tue Nov 01 00:00:00 EDT 2011
cyclase
