|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Storage buffer||PBS with 4mg/ml BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Miscellaneous PubMed (MISC)||See 6 publications below|
Commonly used, FITC conjugates provide relatively high absorptivity, excellent fluorescence quantum yield, and good water solubility.
CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. Another role of CD38 is provided by enzymatic activity of its extracellular part. CD38 acts as NAD+ glycohydrolase converting NAD+ into ADP-ribose, as ADP-ribosyl cyclase producing cADPR and as cADPR hydrolase, thus affecting levels of calcium-mobilizing metabolites. ADPR produced by CD38 serves as an important second messenger of neutrophil and dendritic cell migration.
Analyte Specific Reagent
Identification of four human cDNAs that are differentially expressed by early hematopoietic progenitors.
MHCD3801-4 was used in flow cytometry to elucidate the molecular processes that maintain the stem cell pool.
|Zhang X,Dormady SP,Basch RS||Experimental hematology (28:1286)||2000|
Expression, regulation, and function of B cell-expressed CD154 in germinal centers.
MHCD3801-4 was used in flow cytometry to investigate the expression and function of B cell CD154.
|Grammer AC,McFarland RD,Heaney J,Darnell BF,Lipsky PE||Journal of immunology (Baltimore, Md. : 1950) (163:4150)||1999|
Different behaviour of fresh and cultured CD34+ cells during immunomagnetic separation.
MHCD3801-4 was used in flow cytometry to characterize CD34+ cells derived from human cord blood after culture.
|Denning-Kendall PA,Horsley H,Donaldson C,Bradley B,Hows JM||British journal of haematology (105:780)||1999|
Characterization of endogenous protoporphyrin IX induced by delta-aminolevulinic acid in resting and activated peripheral blood lymphocytes by four-color flow cytometry.
MHCD3801-4 was used in flow cytometry to determine the effects of delta-aminolevulinic acid and delta-aminolevulinic acid-photodynamic therapy on resting and activated human peripheral blood T lymphocytes.
|Hryhorenko EA,Rittenhouse-Diakun K,Harvey NS,Morgan J,Stewart CC,Oseroff AR||Photochemistry and photobiology (67:565)||1998|
Paracrine regulation of germinal center B cell adhesion through the c-met-hepatocyte growth factor/scatter factor pathway.
MHCD3801-4 was used in flow cytometry to identify c-met-encoded receptor tyrosine kinase and its ligand, HGF/SF, as a novel paracrine signaling pathway that regulates B cell adhesion.
|van der Voort R,Taher TE,Keehnen RM,Smit L,Groenink M,Pals ST||The Journal of experimental medicine (185:2121)||1997|
FLK-2/FLT-3 ligand regulates the growth of early myeloid progenitors isolated from human fetal liver.
MHCD3801-4 was used in flow cytometry to assess the effects of the FLK-2/FLT-3 ligand on the growth of human fetal liver progenitors.
|Muench MO,Roncarolo MG,Menon S,Xu Y,Kastelein R,Zurawski S,Hannum CH,Culpepper J,Lee F,Namikawa R||Blood (85:963)||1995|