|Tested species reactivity||Human, Mouse|
|Published species reactivity||Rabbit, Human, Not Applicable|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant protein encoding the extracellular domain of human CD38|
|Storage buffer||tissue culture supernatant|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:2|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
|Western Blot (WB)||1:50-1:200|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-14413 targets CD38 in WB, FACS and IHC (P) applications and shows reactivity with Human and Mouse samples. This antibody is not suitable for Jurkat cell lysates or mouse thymus tissues in Western blot analysis.
The MA5-14413 immunogen is recombinant protein encoding the extracellular domain of human CD38.
CD38 is a single chain type II integral transmembrane protein, which is highly expressed on thymocytes. It is also present on activated T cells and terminally differentiated B cells (plasma cells). Other reactive cells include NK cells, monocytes, macrophages, and dendritic cells. CD38 may be detected on cells from multiple myeloma, ALL (B and T) and some AML. It is, however, not found on most mature resting peripheral lymphocytes. CD38 functions as a multicatalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ glycohydrolase or as a cell surface receptor. Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e. identification of myelomas), and as a marker for activated B and T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Plasma cells within granulomatous inflammation display signs pointing to autoreactivity and destruction in granulomatosis with polyangiitis.
MA5-14413 was used in immunohistochemistry - paraffin section to describe the features of plasma cells in patients with granulomatosis with polyangiitis
|Mueller A,Brieske C,Schinke S,Csernok E,Gross WL,Hasselbacher K,Voswinkel J,Holl-Ulrich K||Arthritis research and therapy (16:null)||2014|
VR09 cell line: an EBV-positive lymphoblastoid cell line with in vivo characteristics of diffuse large B cell lymphoma of activated B-cell type.
MA5-14413 was used in immunohistochemistry - paraffin section to discuss how Epstein-Barr virus contributes to the development of small B-cell neoplasms
|Nichele I,Zamò A,Bertolaso A,Bifari F,Tinelli M,Franchini M,Stradoni R,Aprili F,Pizzolo G,Krampera M||PloS one (7:null)||2013|
Analysis of the IgVH genes in T cell-mediated and antibody-mediated rejection of the kidney graft.
MA5-14413 was used in immunohistochemistry to investigate the role of IgVH genes in host-graft rejection in renal transplants
|Bellan C,Amato T,Carmellini M,Onorati M,D'Amuri A,Leoncini L,del Vecchio MT||Journal of clinical pathology (64:47)||2011|
Diagnostic and differential diagnostic criteria of lymphoid neoplasms in bone marrow trephine biopsies: a study of 87 cases.
MA5-14413 was used in immunohistochemistry to investigate the diagnosis of lymphoid neoplasmas through bone marrow trephine biopsies
|Horváth E,Mezei T,Pávai Z,Turcu M,Demian S,Tóth E,Chira L,Jung I||Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie (50:399)||2009|
Human adult craniofacial muscle-derived cells: neural-cell adhesion-molecule (NCAM; CD56)-expressing cells appear to contain multipotential stem cells.
MA5-14413 was used in immunocytochemistry to characterize muscle-derived multipotential stem cells
|Sinanan AC,Hunt NP,Lewis MP||Biotechnology and applied biochemistry (40:25)||2004|
Channelling of substrate promiscuity of the skeletal-muscle ADP-ribosyl cyclase isoform.
MA5-14413 was used in western blot to generate enzymatic data supporting the presence in skeletal muscle of an ADP-ribosyl cyclase isoform distinct from CD38
|Bacher I,Zidar A,Kratzel M,Hohenegger M||The Biochemical journal (381:147)||2004|