|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human thymocytes in fetus.|
|Storage buffer||PBS with 0.2% BSA|
|Contains||15mM sodium azide|
|Storage Conditions||4° C, store in dark, DO NOT FREEZE!|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||10ul x 100ul whole blood or 10^6 cells|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. Another role of CD38 is provided by enzymatic activity of its extracellular part. CD38 acts as NAD+ glycohydrolase converting NAD+ into ADP-ribose, as ADP-ribosyl cyclase producing cADPR and as cADPR hydrolase, thus affecting levels of calcium-mobilizing metabolites. ADPR produced by CD38 serves as an important second messenger of neutrophil and dendritic cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Not Applicable||Not Cited||
Molecular signature of CD34(+) hematopoietic stem and progenitor cells of patients with CML in chronic phase.
MA1-19773 was used in flow cytometry to characterize CD34+ cells from bone marrow of untreated patients with chronic myelogenous leukemia in chronic phase
|Diaz-Blanco E,Bruns I,Neumann F,Fischer JC,Graef T,Rosskopf M,Brors B,Pechtel S,Bork S,Koch A,Baer A,Rohr UP,Kobbe G,von Haeseler A,Gattermann N,Haas R,Kronenwett R||Leukemia (21:494)||2007|
Efficient transduction of human hematopoietic repopulating cells generating stable engraftment of transgene-expressing cells in NOD/SCID mice.
MA1-19773 was used in flow cytometry to assess the repopulating potential of transduced grafts.
|Barquinero J,Segovia JC,Ramírez M,Limón A,Güenechea G,Puig T,Briones J,García J,Bueren JA||Blood (95:3085)||2000|