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Histogram of gated human monocytes labeled with CD38 Mouse Anti-Human mAb (clone HIT2) Qdot® 655 conjugate. Sample was acquired and analyzed using 405 nm excitation specified band pass emission filter on an Attune® Acoustic Focusing Cytometer (Life technologies, Carlsbad,CA). The black line histograms represent cells stained with anti-human CD38 antibody conjugate, and the gray line represents unstained cells.
|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Storage buffer||0.05M borate, pH 8.3, with 1M betaine|
|Contains||0.05% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. Another role of CD38 is provided by enzymatic activity of its extracellular part. CD38 acts as NAD+ glycohydrolase converting NAD+ into ADP-ribose, as ADP-ribosyl cyclase producing cADPR and as cADPR hydrolase, thus affecting levels of calcium-mobilizing metabolites. ADPR produced by CD38 serves as an important second messenger of neutrophil and dendritic cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
ADP-ribosyl cyclase 1, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase, CD38 antigen (p45), NAD(+) nucleosidase, cADPr hydrolase 1, cyclic ADP-ribose hydrolase 1, CD38 antigen p45, NAD+ nucleosidase