|Flow Cytometry (Flow)||Neat|
|Tested Species reactivity||Dog|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Affinity enriched TCR/CD3 membrane proteins isolated from thymocytes and the T cell line CLGL-90|
|Excitation/Emission Profile||View spectra|
|Storage buffer||PBS with 1% BSA|
|Contains||0.09% sodium azide|
|Storage conditions||4°C or -20°C if preferred, store in dark|
For FACS analysis, use 10ul of the suggested working dilution to label 1x10^6 cells in 100ul.
T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD3 epsilon; CD3-epsilon; CD3e; CD3e antigen; CD3E antigen, epsilon polypeptide (TiT3 complex); epsilon polypeptide TiT3 complex; epsilon subunit of T3; FLJ18683; T-cell antigen receptor complex; T-cell surface glycoprotein CD3 epsilon chain; T3E; TCRE
Gene Aliases: CD3E
UniProt ID: (Dog) P27597
Entrez Gene ID: (Dog) 442981
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