|Tested species reactivity||Human, Mouse|
|Published species reactivity||Rat, Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide corresponding to residues in the cytoplasmic domain of human CD3epsilon. The antibody does not cross react with other subunits of CD3.|
|Storage buffer||tissue culture supernatant|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:125|
|Western Blot (WB)||1:10-1:100|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 2 publications below|
MA5-14482 targets CD3E in IHC (P) and Western blot applications and shows reactivity with Human and Mouse samples.
The MA5-14482 immunogen is a synthetic peptide corresponding to residues in the cytoplasmic domain of human CD3epsilon. The antibody does not cross react with other subunits of CD3.
CD3 consists of five different polypeptide chains (designated as gamma, delta, epsilon, zeta, and eta). The CD3 complex is closely associated at the lymphocyte cell surface with the T cell antigen receptor (TCR). It is involved in signal transduction to the T cell interior following antigen recognition. CD3 antigen is a highly specific marker for T cells, and is present in majority of T cell neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Alteration of hepatic structure and oxidative stress induced by intravenous nanoceria.
MA5-14482 was used in immunohistochemistry to study the effects of intravenous nanoceria on hepatic injury and oxidative stress
|Tseng MT,Lu X,Duan X,Hardas SS,Sultana R,Wu P,Unrine JM,Graham U,Butterfield DA,Grulke EA,Yokel RA||Toxicology and applied pharmacology (260:173)||2012|
Hepatitis C virus induces the expression of CCL17 and CCL22 chemokines that attract regulatory T cells to the site of infection.
MA5-14482 was used in immunohistochemistry to study the role of CCL17 and CCL22 in Foxp3+ T regulatory cell accumulation at the site of HCV infection
|Riezu-Boj JI,Larrea E,Aldabe R,Guembe L,Casares N,Galeano E,Echeverria I,Sarobe P,Herrero I,Sangro B,Prieto J,Lasarte JJ||Journal of hepatology (54:422)||2011|