Note: You clicked on an external link, which has been disabled in order to keep your shopping session open.
|Tested species reactivity||Primate|
|Published species reactivity||Primate|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Rhesus monkey peripheral blood leukocytes.|
|Storage buffer||PBS with 125mM trehalose, 1% BSA|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 1 publications below|
CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Biocompatible anionic polymeric microspheres as priming delivery system for effetive HIV/AIDS Tat-based vaccines.
APS0308 was used in flow cytometry to describe a prime-boost regimen for the HIV vaccination of Macaca fascicularis.
|Titti F,Maggiorella MT,Ferrantelli F,Sernicola L,Bellino S,Collacchi B,Fanales Belasio E,Moretti S,Pavone Cossut MR,Belli R,Olivieri E,Farcomeni S,Compagnoni D,Michelini Z,Sabbatucci M,Sparnacci K,Tondelli L,Laus M,Cafaro A,Caputo A,Ensoli B||PloS one (9:null)||2014|
CD3-epsilon; CD3e antigen; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); epsilon polypeptide TiT3 complex; epsilon subunit of T3; FLJ18683; T-cell antigen receptor complex; T-cell antigen receptor complex, epsilon subunit of T3; T-cell surface antigen T3/Leu-4 epsilon chain; T3E; TCRE
CD3E; IMD18; T3E; TCRE