|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 13-mer peptide corresponding to aa 156-168 of the epsilon chain of human CD3 protein.|
|Storage buffer||whole serum|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-30878 detects CD3e from human samples.
PA1-30878 has been successfully used in immunohistochemistry (paraffin tissue) applications.
The PA1-30878 immunogen is: Synthetic 13-mer peptide corresponding to aa 156-168 of the epsilon chain of human CD3 protein.
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.