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|Tested species reactivity||Human|
|Published species reactivity||Human, Mouse|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Stimulated human leukocytes|
|Storage buffer||tissue culture supernatant|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:2|
|Immunohistochemistry (Paraffin) (IHC (P))||1:10-1:20|
|Western Blot (WB)||1:10-1:100|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-12259 targets CD4 in IHC (P), WB and FACS applications and shows reactivity with Human samples.
The MA5-12259 immunogen is stimulated human leukocytes.
CD4, a single chain transmembrane glycoprotein, is found on a T cell subset (helper/inducer) representing 45% of peripheral blood lymphocytes. It is also present on 80% of thymocytes and at a lower level on monocytes. It is involved in recognition of antigen presented along with MHC class II by APCs. It serves as receptor for HIV.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
High frequency of CD8 positive lymphocyte infiltration correlates with lack of lymph node involvement in early rectal cancer.
MA5-12259 was used in immunohistochemistry to study the role of lymph node in the early rectal cancer
|Däster S,Eppenberger-Castori S,Hirt C,Zlobec I,Delko T,Nebiker CA,Soysal SD,Amicarella F,Iezzi G,Sconocchia G,Heberer M,Lugli A,Spagnoli GC,Kettelhack C,Terracciano L,Oertli D,von Holzen U,Tornillo L,Droeser RA||Disease markers (2014:null)||2015|
Expression of T-cell KV1.3 potassium channel correlates with pro-inflammatory cytokines and disease activity in ulcerative colitis.
MA5-12259 was used in immunohistochemistry to study the correlation between the expression KV1.3 channels and pro-inflammatory cytokines by T-cells and disease severity in patients with ulcerative colitis
|Koch Hansen L,Sevelsted-Møller L,Rabjerg M,Larsen D,Hansen TP,Klinge L,Wulff H,Knudsen T,Kjeldsen J,Köhler R||Journal of Crohn's & colitis (8:1378)||2014|
Immunological changes and increased expression of myxovirus resistance protein a in thyroid tissue of patients with recent onset and untreated Graves' disease.
MA5-12259 was used in immunohistochemistry to study the immunopathology and expression of myxovirus resistance protein a in the thyroid of patients newly diagnosed with Graves' disease
|Hammerstad SS,Jahnsen FL,Tauriainen S,Hyöty H,Paulsen T,Norheim I,Dahl-Jørgensen K||Thyroid : official journal of the American Thyroid Association (24:537)||2014|
T cell-activation in neuromyelitis optica lesions plays a role in their formation.
MA5-12259 was used in immunohistochemistry to study the role of T-cell activation in the formation of neuromyelitis optica lesions
|Pohl M,Kawakami N,Kitic M,Bauer J,Martins R,Fischer MT,Machado-Santos J,Mader S,Ellwart JW,Misu T,Fujihara K,Wekerle H,Reindl M,Lassmann H,Bradl M||Acta neuropathologica communications (1:null)||2014|
Tumor-infiltrating lymphocytes, tumor characteristics, and recurrence in patients with early breast cancer.
MA5-12259 was used in immunohistochemistry to study the relationships between tumor-infiltrating lymphocytes, breast cancer characteristics and tumor recurrence
|Kim ST,Jeong H,Woo OH,Seo JH,Kim A,Lee ES,Shin SW,Kim YH,Kim JS,Park KH||American journal of clinical oncology (36:224)||2013|
Inflammation and increased myxovirus resistance protein A expression in thyroid tissue in the early stages of Hashimoto's thyroiditis.
MA5-12259 was used in immunohistochemistry to study the role of inflammation and expression of myxovirus resistance protein A in the pathogenesis of Hashimoto's thyroiditis
|Hammerstad SS,Jahnsen FL,Tauriainen S,Hyöty H,Paulsen T,Norheim I,Dahl-Jørgensen K||Thyroid : official journal of the American Thyroid Association (23:334)||2013|
Immunohistochemical correlation between microvessel density and lymphoid infiltrate in radicular cysts.
MA5-12259 was used in immunohistochemistry to study the relationship between the density of microvessels and lymphoid infiltration in radicular cysts
|Zizzi A,Aspriello SD,Ferrante L,Stramazzotti D,Colella G,Balercia P,Lo Muzio L,Piemontese M,Goteri G,Rubini C||Oral diseases (19:92)||2013|
Tumor-infiltrating lymphocytes contain a higher proportion of FOXP3(+) T lymphocytes in cervical cancer.
MA5-12259 was used in immunohistochemistry to study the distribution of tumor-infiltrating lymphocytes and FOXP3(+) cells in cervical cancer and cervical intraepithelial neoplasia
|Wu MY,Kuo TY,Ho HN||Journal of the Formosan Medical Association = Taiwan yi zhi (110:580)||2011|
Innate and adaptive immunity in amyotrophic lateral sclerosis: evidence of complement activation.
MA5-12259 was used in immunohistochemistry to study the activation of innate and adaptive immunity in amyotrophic lateral sclerosis
|Sta M,Sylva-Steenland RM,Casula M,de Jong JM,Troost D,Aronica E,Baas F||Neurobiology of disease (42:211)||2011|
Hepatitis C virus induces the expression of CCL17 and CCL22 chemokines that attract regulatory T cells to the site of infection.
MA5-12259 was used in immunohistochemistry to study the role of CCL17 and CCL22 in Foxp3+ T regulatory cell accumulation at the site of HCV infection
|Riezu-Boj JI,Larrea E,Aldabe R,Guembe L,Casares N,Galeano E,Echeverria I,Sarobe P,Herrero I,Sangro B,Prieto J,Lasarte JJ||Journal of hepatology (54:422)||2011|
Disruption of intestinal CD4+ T cell homeostasis is a key marker of systemic CD4+ T cell activation in HIV-infected individuals.
MA5-12259 was used in immunohistochemistry to investigate the role of intestinal CD4+ T cell homeostasis in HIV-infected individuals
|Gordon SN,Cervasi B,Odorizzi P,Silverman R,Aberra F,Ginsberg G,Estes JD,Paiardini M,Frank I,Silvestri G||Journal of immunology (Baltimore, Md. : 1950) (185:5169)||2010|
B-cell lymphofollicular infiltrates in mycosis fungoides.
MA5-12259 was used in immunohistochemistry to investigate specific histopathological features of B-cell lymphofollicular infiltrates in mycosis fungoides
|Ferrara G,Chiarelli C,Simonetti S||Tumori (96:487)||2010|
Characterization of hepatitis C virus-induced nasal mucosa remodelling.
MA5-12259 was used in immunohistochemistry to study HCV-induced nasal mucosa remodelling
|El-Shazly A,Arafa M,Roncarati P,Dortu E,Lefebvre PP,Delvenne P||Histopathology (57:488)||2010|
Tracking the rejection and survival of mouse ovarian iso- and allografts in vivo with bioluminescent imaging.
MA5-12259 was used in immunohistochemistry to study the use of bioluminescent imaging in transgenic mice to monitor the survival and rejection of ovarian isografts and allografts
|Chen CH,Yeh YC,Wu GJ,Huang YH,Lai WF,Liu JY,Tzeng CR||Reproduction (Cambridge, England) (140:105)||2010|
FOXP3 T regulatory cells in lesions of oral lichen planus correlated with disease activity.
MA5-12259 was used in immunohistochemistry to investigate the influence of FOXP3 T regulatory cells in the pathogenesis of oral lichen planus
|Tao XA,Xia J,Chen XB,Wang H,Dai YH,Rhodus NL,Cheng B||Oral diseases (16:76)||2010|
Collagen deposition limits immune reconstitution in the gut.
MA5-12259 was used in immunohistochemistry to examine the effect of collagen deposition on gut CD4 cell reconstitution after antiretroviral therapy
|Estes J,Baker JV,Brenchley JM,Khoruts A,Barthold JL,Bantle A,Reilly CS,Beilman GJ,George ME,Douek DC,Haase AT,Schacker TW||The Journal of infectious diseases (198:456)||2008|
Gene expression profile analysis of epilepsy-associated gangliogliomas.
MA5-12259 was used in immunohistochemistry to study the gene expression profile of gangliogliomas associated with epilepsy
|Aronica E,Boer K,Becker A,Redeker S,Spliet WG,van Rijen PC,Wittink F,Breit T,Wadman WJ,Lopes da Silva FH,Troost D,Gorter JA||Neuroscience (151:272)||2008|
Selective expansion of influenza A virus-specific T cells in symptomatic human carotid artery atherosclerotic plaques.
MA5-12259 was used in immunohistochemistry to study the role of influenza A virus infection in atherothrombotic disease
|Keller TT,van der Meer JJ,Teeling P,van der Sluijs K,Idu MM,Rimmelzwaan GF,Levi M,van der Wal AC,de Boer OJ||Stroke; a journal of cerebral circulation (39:174)||2008|
NK- and B-cell infiltration correlates with worse outcome in metastatic ovarian carcinoma.
MA5-12259 was used in immunohistochemistry to study the correlation of NK- and B-cell infiltration with outcome in metastatic ovarian carcinoma
|Dong HP,Elstrand MB,Holth A,Silins I,Berner A,Trope CG,Davidson B,Risberg B||American journal of clinical pathology (125:451)||2006|
Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia.
MA5-12259 was used in immunohistochemistry to study CD25 and CD27 coexpression as a marker of FoxP3+ regulatory T cells in inflammed synovium
|Ruprecht CR,Gattorno M,Ferlito F,Gregorio A,Martini A,Lanzavecchia A,Sallusto F||The Journal of experimental medicine (201:1793)||2005|
Phenotypic and functional characterisation of CCR7+ and CCR7- CD4+ memory T cells homing to the joints in juvenile idiopathic arthritis.
MA5-12259 was used in immunohistochemistry to study the functional characteristics of CCR7+ and CCR7- CD4+ memory T cells homing to the joints in juvenile idiopathic arthritis.
|Gattorno M,Prigione I,Morandi F,Gregorio A,Chiesa S,Ferlito F,Favre A,Uccelli A,Gambini C,Martini A,Pistoia V||Arthritis research & therapy (7:R256)||2005|
Inflammatory processes in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex.
MA5-12259 was used in immunocytochemistry to study inflammatory processes in cerebral lesions associated with tuberous sclerosis complex
|Boer K,Jansen F,Nellist M,Redeker S,van den Ouweland AM,Spliet WG,van Nieuwenhuizen O,Troost D,Crino PB,Aronica E||Epilepsy research (78:7)||2008|
CD4 antigen (p55); CD4 antigen p55; CD4 receptor; T-cell surface antigen T4/Leu-3