|Tested species reactivity||Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rat / IgG2b|
|Immunogen||Mouse CTL clone V4 cells|
|Storage buffer||PBS, pH 7.4|
|Contains||15mM sodium azide|
|Storage Conditions||4° C, store in dark, DO NOT FREEZE!|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||3 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Development of thymic microenvironments in vitro is oxygen-dependent and requires permanent presence of T-cell progenitors.
MA1-10220 was used in flow cytometry to investigate factors that mediate induction and maintenance of the 3D configuration of the epithelial network in fetal thymic lobes in vitro.
|Germeraad WT,Kawamoto H,Itoi M,Jiang Y,Amagai T,Katsura Y,van Ewijk W||The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society (51:1225)||2003|
Commitment of common T/Natural killer (NK) progenitors to unipotent T and NK progenitors in the murine fetal thymus revealed by a single progenitor assay.
MA1-10220 was used in flow cytometry to describe a clonal system that supports the development of T and natural killer cells evenly.
|Ikawa T,Kawamoto H,Fujimoto S,Katsura Y||The Journal of experimental medicine (190:1617)||1999|
Emergence of T, B, and myeloid lineage-committed as well as multipotent hemopoietic progenitors in the aorta-gonad-mesonephros region of day 10 fetuses of the mouse.
MA1-10220 was used in flow cytometry to investigate the aorta-gonad-mesonephros region as a source of hemopoietic progenitors.
|Ohmura K,Kawamoto H,Fujimoto S,Ozaki S,Nakao K,Katsura Y||Journal of immunology (Baltimore, Md. : 1950) (163:4788)||1999|
Emergence of T cell progenitors without B cell or myeloid differentiation potential at the earliest stage of hematopoiesis in the murine fetal liver.
MA1-10220 was used in flow cytometry to assess if progenitors colonizing the thymus are T cell lineage restricted.
|Kawamoto H,Ohmura K,Fujimoto S,Katsura Y||Journal of immunology (Baltimore, Md. : 1950) (162:2725)||1999|
B7 blockade prevents activation-induced cell death of thymocytes.
MA1-10220 was used in flow cytometry to elucidate the role of B7 in thymic selection.
|Samoilova EB,Horton JL,Bassiri H,Zhang H,Linsley PS,Carding SR,Chen Y||International immunology (9:1663)||1997|
Extrathymic maturation of alpha beta T cells from hemopoietic stem cells.
MA1-10220 was used in flow cytometry to test if alpha beta T cells develop from hematopoietic stem cells in the absence of the thymus.
|Dejbakhsh-Jones S,Jerabek L,Weissman IL,Strober S||Journal of immunology (Baltimore, Md. : 1950) (155:3338)||1995|
Progression of T cell lineage restriction in the earliest subpopulation of murine adult thymus visualized by the expression of lck proximal promoter activity.
MA1-10220 was used in flow cytometry to study regulation of the lck in T cell lineage commitment.
|Shimizu C,Kawamoto H,Yamashita M,Kimura M,Kondou E,Kaneko Y,Okada S,Tokuhisa T,Yokoyama M,Taniguchi M,Katsura Y,Nakayama T||International immunology (13:105)||2001|