|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Mouse / IgG2a|
|Storage buffer||0.05M borate, pH 8.3, with 1M betaine|
|Contains||0.05% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The CD4 antigen is involved in the recognition of the type II MHC antigen. It is also a receptor for HIV. It is present on most T helper cells and normal thymocytes. The cytoplasmic portion of CD4 is associated with p56lck tyrosine kinase. CD4 expression is commonly found in human lymph nodes and tonsils. CD44 is a type 1 transmembrane glycoprotein also known as Phagocytic Glycoprotein-1 (pgp-1) and HCAM. CD44 is the receptor for hyaluronate and exists as a large number of different isoforms due to alternative RNA splicing. The major isoform expressed on lymphocytes, myeloid cells, and erythrocytes is a glycosylated type 1 transmembrane protein. Other isoforms contain glycosaminoglycans and are expressed on hematopoietic and non-hematopoietic cells. CD44 is involved in adhesion of leukocytes to endothelial cells, stromal cells, and the extracellular matrix.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Transient decrease in human peripheral blood myeloid dendritic cells following influenza vaccination correlates with induction of serum antibody.
Q10007 was used in flow cytometry to examine various DC after flu vaccination
|Kobie JJ,Treanor JJ,Ritchlin CT||Immunological investigations (43:606)||2014|
|Not Applicable||Not Cited||
Leukocyte composition of human breast cancer.
Q10007 was used in flow cytometry to examine tumor and nonadjacent normal breast tissue from women with breast cancer, who either had or had not received neoadjuvant chemotherapy before surgery
|Ruffell B,Au A,Rugo HS,Esserman LJ,Hwang ES,Coussens LM||Proceedings of the National Academy of Sciences of the United States of America (109:2796)||2012|
Potent CD8+ T-cell immunogenicity in humans of a novel heterosubtypic influenza A vaccine, MVA-NP+M1.
Q10007 was used in flow cytometry to discuss the use of internal antigens to provide better protection against multiple influenza subtypes.
|Berthoud TK,Hamill M,Lillie PJ,Hwenda L,Collins KA,Ewer KJ,Milicic A,Poyntz HC,Lambe T,Fletcher HA,Hill AV,Gilbert SC||Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (52:1)||2011|
Heterogeneity of multifunctional IL-17A producing S. Typhi-specific CD8+ T cells in volunteers following Ty21a typhoid immunization.
Q10007 was used in flow cytometry to explore the multifunctional IL-17A responses against S. Typhi antigens in T memory subsets.
|McArthur MA,Sztein MB||PloS one (7:null)||2012|