|Tested species reactivity||Non-human primate, Human|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Human T lymphocytes.|
|Storage buffer||PBS, pH 7.4|
|Storage Conditions||4°C or -20°C if preferred|
|Tested Applications||Dilution *|
|Flow Cytometry (FACS)||1/50 - 1/100|
|Immunofluorescence (IF)||Assay Dependent|
|Immunohistochemistry (Paraffin, Frozen) (IHC (P, F))||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
For FACS analysis, use 10ul of the suggested working dilution to label 1x10^6 cells in 100ul. A suggested positive control for immunohistochemical applications is human tonsil.
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Signal transduction Intracellular signaling cascade MAPKKK cascade Cell communication Cell adhesion-mediated signaling Immunity and defense Oncogenesis Other oncogenesis Apoptosis Inhibition of apoptosis Cell structure and motility Cell motility Cell adhesion