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|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Mouse / IgG1|
|Immunogen||The epitope recognized by this antibody is a variant portion of CD44 encoded by exon v6. While the standard CD44 is observed to have ubiquitous expression, CD44 v6 expression appears to be limited to activated lymphocytes and macrophages.|
|Storage buffer||proprietary buffer|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
|Immunohistochemistry (IHC)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CD44 cell surface antigen is a 100kDa glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Erythropoietin-driven proliferation of cells with mutations in the tumor suppressor gene TSC2.
AHS4468 was used in flow cytometry to assess the effects of erythropoietin in human cells with loss of tuberin function
|Ikeda Y,Taveira-DaSilva AM,Pacheco-Rodriguez G,Steagall WK,El-Chemaly S,Gochuico BR,May RM,Hathaway OM,Li S,Wang JA,Darling TN,Stylianou M,Moss J||American journal of physiology. Lung cellular and molecular physiology (300:L64)||2011|
|Not Applicable||Not Cited||
TSC2 loss in lymphangioleiomyomatosis cells correlated with expression of CD44v6, a molecular determinant of metastasis.
AHS4468 was used in flow cytometry to analyze the presence of the hyaluronic acid receptor CD44 and splice variants associated with metastasis on lymphangioleiomyomatosis cells
|Pacheco-Rodriguez G,Steagall WK,Crooks DM,Stevens LA,Hashimoto H,Li S,Wang JA,Darling TN,Moss J||Cancer research (67:10573)||2007|
AL133330.1; CD44; CD44 antigen; CD44 V6; CD44v6; CDW44; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; CSPG8; ECMR-III; Epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; HCELL; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; homing function and Indian blood group system; HUTCH-I; Hyaluronate receptor; IN; MC56; MDU2; MDU3; MIC4; PGP-1; PGP-I; Pgp1; Phagocytic glycoprotein 1; Phagocytic glycoprotein I; soluble CD44
CD44; CDW44; CSPG8; ECMR-III; HCELL; HUTCH-I; IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1