|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Storage buffer||TBS, pH 7.2-7.4, with 1% BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 1 publications below|
Description: Specifically recognizes an epitope encoded by exon v6 on the variant portion of human CD44.
Standard CD44 (CD44s) lacks the entire variable region and is found mainly in cells of lymphohematopoietic origin. The multiple isoforms (designated CD44v; v = variant) contain alternatively spliced exons inserted within the extracellular domain. These isoforms are known as CD44v1, CD44v2, CD44v3, CD44v4, CD44v5, CD44v6, CD44v7, CD44v8, CD44v9, CD44v10, CD44v11.
Applications Tested: Flow Cytometry.
Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser
CD44 cell surface antigen is a 100kDa glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Erythropoietin-driven proliferation of cells with mutations in the tumor suppressor gene TSC2.
BMS116FI was used in flow cytometry to assess the effects of erythropoietin in human cells with loss of tuberin function
|Ikeda Y,Taveira-DaSilva AM,Pacheco-Rodriguez G,Steagall WK,El-Chemaly S,Gochuico BR,May RM,Hathaway OM,Li S,Wang JA,Darling TN,Stylianou M,Moss J||American journal of physiology. Lung cellular and molecular physiology (300:L64)||2011|