|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG2|
|Contains||0.01% sodium azide|
|Storage Conditions||4°C or -80°C if preferred|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:1000|
|Immunohistochemistry (Frozen) (IHC (F))||1:1000|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
MA1-7636 detects CD45 from human samples.
MA1-7636 has been successfully used in Western blot, flow cytometry and immunohistochemistry (frozen) procedures.
The MA1-7636 immunogen is a CD45 RA protein.
CD45 is a family of single chain transmembraneous glycoproteins consisting of at least four isoforms which share a common large intracellular domain. Their extracellular domains are heavily glycosylated. The different isoforms are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1. CD45 is expressed on cells of the human hematopoietic lineage with the exception of mature red cells. It is not detected on differentiated cells of other tissues. It is likely that CD45 plays an important role in signal transduction, inhibition or upregulation of various immunological functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Major histocompatibility complex class I-intercellular adhesion molecule-1 association on the surface of target cells: implications for antigen presentation to cytotoxic T lymphocytes.
MA1-7636 was used in western blot to study the association between major histocompatibility complex class I and intercellular adhesion molecule-1
|Lebedeva T,Anikeeva N,Kalams SA,Walker BD,Gaidarov I,Keen JH,Sykulev Y||Immunology (113:460)||2004|