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|Tested species reactivity||Human|
|Published species reactivity||Mouse, Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Clone||PD7/26/16 + 2B11|
|Immunogen||PD7/26/16: human peripheral blood lymphocytes maintained in T cell growth factor. 2B11: isolated neoplastic cells from T cell lymphoma.|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||0.5 ug/test|
|Immunofluorescence (IF)||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||1:200|
|Western Blot (WB)||1:10-1:100|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-13197 targets CD45 in FACS, IF, WB and IHC (P) applications and shows reactivity with Human samples.
The MA5-13197 immunogen is pD7/26/16: human peripheral blood lymphocytes maintained in T cell growth factor. 2B11: isolated neoplastic cells from T cell lymphoma.
CD45 leucocyte common antigen (LCA)belongs to the family of at least four isoforms of membrane glycoproteins (220, 205, 190, 180kDa) expressed on hematopoietic cell lines but absent on non-hematopoietic cell lines, normal and malignant non-hematopoietic tissues. The intracellular portion of these molecules have protein phosphatase activity and are involved in regulation of transmembrane signals. Antibody to CD45 is useful in differential identification of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
An improved protocol for efficient engraftment in NOD/LTSZ-SCIDIL-2Rγnull mice allows HIV replication and development of anti-HIV immune responses.
MA5-13197 was used in immunohistochemistry to develop a novel murine model for studying HIV-1 infection and therapy
|Singh M,Singh P,Gaudray G,Musumeci L,Thielen C,Vaira D,Vandergeeten C,Delacroix L,Van Gulck E,Vanham G,de Leval L,Rahmouni S,Moutschen M||PloS one (7:null)||2012|
Composite lymphoma in the anterior mediastinum: a case report and review of the literature.
MA5-13197 was used in immunohistochemistry to present a case report of an unusual composite lymphoma in the mediastinum
|Yu G,Kong L,Qu G,Zhang Q,Wang W,Jiang L||Diagnostic pathology (6:null)||2011|
A 19-year follow-up of a patient with type 3 ectrodactyly-ectodermal dysplasia-clefting syndrome who developed non-Hodgkin lymphoma.
MA5-13197 was used in immunohistochemistry to perform clinical, radiologic and histopathologic studies of a patient with type 3 ectrodactyly-ectodermal dysplasia-clefting syndrome
|Balci S,Engiz O,Okten G,Sipahier M,Gursu G,Kandemir B||Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics (108:e91)||2009|
Invasive inflammatory pseudotumor of uterine cervix: a case report.
MA5-13197 was used in immunohistochemistry to report on a case of invasive inflammatory pseudotumor of the uterine cervix
|Gücer F,Altaner S,Mülayim N,Yapicier O||Gynecologic oncology (98:325)||2005|
CIK cells from patients with HCC possess strong cytotoxicity to multidrug-resistant cell line Bel-7402/R.
MA5-13197 was used in immunohistochemistry to investigate the effectiveness of cytokine-induced killer cell treatment in patient with hepatocellular carcinoma
|Zhang YS,Yuan FJ,Jia GF,Zhang JF,Hu LY,Huang L,Wang J,Dai ZQ||World journal of gastroenterology (11:3339)||2005|
Involvement of the Fas/FasL pathway in the pathogenesis of germ cell tumours of the adult testis.
MA5-13197 was used in immunohistochemistry to study the role of Fas/FasL signals in the pathogenesis of testis germ cell tumours
|Kersemaekers AM,van Weeren PC,Oosterhuis JW,Looijenga LH||The Journal of pathology (196:423)||2002|
Differentiation of human mesenchymal stem cells: the potential mechanism for estrogen-induced preferential osteoblast versus adipocyte differentiation.
MA5-13197 was used in flow cytometry to investigate the regulatory role of estrogen signaling pathways in the differentiation of mesenchymal stem cells in vitro
|Zhao JW,Gao ZL,Mei H,Li YL,Wang Y||The American journal of the medical sciences (341:460)||2011|
Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate.
MA5-13197 was used in flow cytometry to study the role of genetic background in breast cancer phenotype and its underlying mechanism
|Proia TA,Keller PJ,Gupta PB,Klebba I,Jones AD,Sedic M,Gilmore H,Tung N,Naber SP,Schnitt S,Lander ES,Kuperwasser C||Cell stem cell (8:149)||2011|
[Mesenchymal stem cells transduced by PLEGFP-N1 retroviral vector maintain their biological features and differentiation].
MA5-13197 was used in flow cytometry to evaluate the utility of enhanced green fluorescent protein transduction in human mesenchymal stem cells
|He X,Li YL,Wang XR,Guo X,Niu Y||Chinese medical journal (118:1728)||2005|
B220; c polypeptide; CD45; CD45 antigen; CD45R; GP180; L-CA; LCA; LY5; protein tyrosine phosphatase; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; receptor type; receptor-type tyrosine-protein phosphatase C; T200 glycoprotein; T200 leukocyte common antigen
B220; CD45; CD45R; GP180; L-CA; LCA; LY5; PTPRC; T200