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|Tested species reactivity||Rat|
|Published species reactivity||Not Applicable|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Rat purified spleen L-CA|
|Storage buffer||PBS with 4-5mg/ml BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||0.5 ug/10^6 cells|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 1 publications below|
MA5-17482 targets CD45RA/B in FACS applications and shows reactivity with Rat samples.
The MA5-17482 immunogen is rat purified spleen L-CA.
CD45 is a family of single chain transmembraneous glycoproteins consisting of at least four isoforms which share a common large intracellular domain. Their extracellular domains are heavily glycosylated. The different isoforms are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1. CD45 is expressed on cells of the human hematopoietic lineage with the exception of mature red cells. It is not detected on differentiated cells of other tissues. It is likely that CD45 plays an important role in signal transduction, inhibition or upregulation of various immunological functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Not Applicable||Not Cited||
Effects of pixantrone on immune-cell function in the course of acute rat experimental allergic encephalomyelitis.
MA5-17482 was used in flow cytometry to study the effect of pixantrone on B cells and lymphomononuclear cells in the course of acute EAE
|Mazzanti B,Biagioli T,Aldinucci A,Cavaletti G,Cavalletti E,Oggioni N,Frigo M,Rota S,Tagliabue E,Ballerini C,Massacesi L,Riccio P,Lolli F||Journal of neuroimmunology (168:111)||2005|
CD45; cluster designation 45RA/B; L-CA; leucocyte common antigen; Leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; Protein tyrosine phosphatase, receptor-type, c polypeptide; PTPRC; Receptor-type tyrosine-protein phosphatase C; T100; T200; T200 glycoprotein
CD45; L-CA; Lca; Ptprc; RT7; T200