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|Tested species reactivity||Human|
|Published species reactivity||Baboon, Human|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Human thymocytes and T lymphocytes.|
|Storage buffer||PBS, pH 7.4|
|Contains||15mM sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1 - 4µg/ml|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 2 publications below|
CD45RA is a high molecular weight isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RA is expressed on native T cells and normal plasma cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Murine CD83-positive T cells mediate suppressor functions in vitro and in vivo.
MA1-19113 was used in flow cytometry to study the role of CD93 molecule in mature dendritic cells and T cells
|Kreiser S,Eckhardt J,Kuhnt C,Stein M,Krzyzak L,Seitz C,Tucher C,Knippertz I,Becker C,Günther C,Steinkasserer A,Lechmann M||Immunobiology (220:270)||2015|
The effects of age and cytomegalovirus on markers of inflammation and lymphocyte populations in captive baboons.
MA1-19113 was used in flow cytometry to study the effect of age, gender, social status and peer group on T cells in baboons
|Willis EL,Eberle R,Wolf RF,White GL,McFarlane D||PloS one (9:null)||2014|
B220; CD45; CD45 antigen; CD45R; GP180; LCA; LY5; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; T200 glycoprotein; T200 leukocyte common antigen
B220; CD45; CD45R; GP180; L-CA; LCA; LY5; PTPRC; T200