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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Human thymocytes and T lymphocytes.|
|Storage buffer||PBS with 0.2% BSA|
|Contains||15mM sodium azide|
|Storage Conditions||4° C, store in dark, DO NOT FREEZE!|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||20 ul/10^6 cells|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 1 publications below|
CD45RA is a high molecular weight isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RA is expressed on native T cells and normal plasma cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4+CD45RA+CD27+ T cells: the potential involvement of interleukin-7 in this process.
MA1-19460 was used in flow cytometry to examine T cell subsets in aging CMV seropositive adults.
|Libri V,Azevedo RI,Jackson SE,Di Mitri D,Lachmann R,Fuhrmann S,Vukmanovic-Stejic M,Yong K,Battistini L,Kern F,Soares MV,Akbar AN||Immunology (132:326)||2011|
B220; CD45; CD45 antigen; CD45R; GP180; L-CA; LCA; Leukocyte common antigen; LY5; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; Receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein; T200 leukocyte common antigen
B220; CD45; CD45R; GP180; L-CA; LCA; LY5; PTPRC; T200