|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Human thymocytes and T lymphocytes.|
|Storage buffer||PBS with 0.2% BSA|
|Contains||15mM sodium azide|
|Storage Conditions||4° C, store in dark, DO NOT FREEZE!|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||20 ul/10^6 cells|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CD45RA is a high molecular weight isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RA is expressed on native T cells and normal plasma cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
IL-12-secreting CD19-targeted cord blood-derived T cells for the immunotherapy of B-cell acute lymphoblastic leukemia.
MA1-19636 was used in flow cytometry to developed a strategy to expand umbilical cord blood T cells and test their effects after transplantation
|Pegram HJ,Purdon TJ,van Leeuwen DG,Curran KJ,Giralt SA,Barker JN,Brentjens RJ||Leukemia (29:415)||2015|
|Not Applicable||Not Cited||
Reciprocal role of GATA-1 and vitamin D receptor in human myeloid dendritic cell differentiation.
MA1-19636 was used in flow cytometry to elucidate factors involved in myeloid dendritic cell differentiation
|Göbel F,Taschner S,Jurkin J,Konradi S,Vaculik C,Richter S,Kneidinger D,Mühlbacher C,Bieglmayer C,Elbe-Bürger A,Strobl H||Blood (114:3813)||2009|
The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes.
MA1-19636 was used in immunocytochemistry to study CXCR4 and CCR5 expression on different T cell subsets using mAbs
|Bleul CC,Wu L,Hoxie JA,Springer TA,Mackay CR||Proceedings of the National Academy of Sciences of the United States of America (94:1925)||1997|