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|Tested species reactivity||Rat|
|Published species reactivity||Not Applicable|
|Host / Isotype||Mouse / IgG1|
|Storage buffer||PBS with 4mg/ml BSA, sucrose|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 2 publications below|
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
New therapy of skin repair combining adipose-derived mesenchymal stem cells with sodium carboxymethylcellulose scaffold in a pre-clinical rat model.
MR6404 was used in flow cytometry to test the efficacy of using sodium carboxymethylcellulose and adipose-derived stem cells to treat skin lesions in a rat model
|Rodrigues C,de Assis AM,Moura DJ,Halmenschlager G,Saffi J,Xavier LL,Fernandes Mda C,Wink MR||PloS one (9:null)||2014|
|Not Applicable||Not Cited||
Effects of pixantrone on immune-cell function in the course of acute rat experimental allergic encephalomyelitis.
MR6404 was used in flow cytometry to study the effect of pixantrone on B cells and lymphomononuclear cells in the course of acute EAE
|Mazzanti B,Biagioli T,Aldinucci A,Cavaletti G,Cavalletti E,Oggioni N,Frigo M,Rota S,Tagliabue E,Ballerini C,Massacesi L,Riccio P,Lolli F||Journal of neuroimmunology (168:111)||2005|
B220; CD45; CD45R; GP180; L-CA; LCA; leucocyte common antigen; Leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; LY5; Protein tyrosine phosphatase, receptor-type, c polypeptide; Receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein
CD45; L-CA; Lca; Ptprc; RT7; T200