|Tested species reactivity||Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rat / IgG2a|
|Immunogen||TH2 cell clones, final boost with TH2 clone D10 Fusion Partner: Ag8.653|
|Storage buffer||PBS with 4-5mg/ml BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||0.5 ug/10^6 cells|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Miscellaneous PubMed (MISC)||See 1 publications below|
MA5-17886 targets CD45RB/PTPRC in FACS applications and shows reactivity with Mouse samples.
The MA5-17886 immunogen is tH2 cell clones, final boost with TH2 clone D10 Fusion Partner: Ag8.653.
CD45 is a family of single chain transmembraneous glycoproteins consisting of at least four isoforms which share a common large intracellular domain. Their extracellular domains are heavily glycosylated. The different isoforms are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1. CD45 is expressed on cells of the human hematopoietic lineage with the exception of mature red cells. It is not detected on differentiated cells of other tissues. It is likely that CD45 plays an important role in signal transduction, inhibition or upregulation of various immunological functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression.
MA5-17886 was used in flow cytometry to determine the role of CD69 in thymocyte development.
|Nakayama T,Kasprowicz DJ,Yamashita M,Schubert LA,Gillard G,Kimura M,Didierlaurent A,Koseki H,Ziegler SF||Journal of immunology (Baltimore, Md. : 1950) (168:87)||2002|