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|Tested species reactivity||Human, Mouse, Non-human primate, Rat|
|Published species reactivity||Human, Mouse, Not Applicable|
|Host / Isotype||Mouse / IgG2a, kappa|
|Immunogen||Interleukin-2-dependent human T lymphocytes|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||0.5-1 ug/test|
|Immunohistochemistry (Paraffin) (IHC (P))||1:200-1:400|
|Western Blot (WB)||1:1-1:100|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-11532 targets CD45RO in WB, FACS and IHC (P) applications and shows reactivity with Human, Mouse, Rat and Non-human primate samples.
The MA5-11532 immunogen is interleukin-2-dependent human T lymphocytes.
CD45RO (an isoform of leukocyte common antigen) is expressed on most thymocytes, monocytes, macrophages and granulocytes. It is not expressed on normal B lymphocytes. Intrathymic T cell maturation progresses from CD45RA-/CD45RO+ to CD45RA+/CD45RO-; while peripheral T cell maturation progresses from CD45RA+/CD45RO- to CD45RA-/CD45RO+.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CD30(+) extranodal natural killer/T-cell lymphoma mimicking phlegmonous myositis: A case report.
MA5-11532 was used in immunohistochemistry (paraffin) to report on a case of CD30-positive extranodal natural killer/T-cell lymphoma.
|Yang YJ,Li YX,Liu YB,Yang M,Liu K||Oncology letters (7:1419)||2014|
Serous effusion cytology of extranodal natural killer/T-cell lymphoma.
MA5-11532 was used in flow cytometry to characterize extranodal natural killer/T-cell lymphoma, nasal type using patient samples.
|Su XY,Huang J,Jiang Y,Tang Y,Li GD,Liu WP||Cytopathology : official journal of the British Society for Clinical Cytology (23:96)||2012|
The significance of multiplex PCR/heteroduplex analysis-based TCR-¿ gene rearrangement combined with laser-capture microdissection in the diagnosis of early mycosis fungoides.
MA5-11532 was used in immunohistochemistry (paraffin) to study the diagnostic value for detecting early mycosis fungoides of a combination of multiplex PCR analyis of TCRgamma gene rearrangements and laser-capture microdissection.
|Yang H,Xu C,Tang Y,Wan C,Liu W,Wang L||Journal of cutaneous pathology (39:337)||2012|
IL-21 can supplement suboptimal Lck-independent MAPK activation in a STAT-3-dependent manner in human CD8(+) T cells.
MA5-11532 was used in flow cytometry to investigate the role of CD8 and antigen in proliferation of CTLs.
|Imataki O,Ansén S,Tanaka M,Butler MO,Berezovskaya A,Milstein MI,Kuzushima K,Nadler LM,Hirano N||Journal of immunology (Baltimore, Md. : 1950) (188:1609)||2012|
Chemokine receptor CCR4 on CD4+ T cells in juvenile rheumatoid arthritis synovial fluid defines a subset of cells with increased IL-4:IFN-gamma mRNA ratios.
MA5-11532 was used in flow cytometry to elucidate the mechanisms that promote recruitment and survival of T cells within the pediatric inflamed joint.
|Thompson SD,Luyrink LK,Graham TB,Tsoras M,Ryan M,Passo MH,Glass DN||Journal of immunology (Baltimore, Md. : 1950) (166:6899)||2001|
Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages.
MA5-11532 was used in flow cytometry to determine the number of CD4, CCR5, and CXCR4 antibody-binding sites on various T cells and macrophages.
|Lee B,Sharron M,Montaner LJ,Weissman D,Doms RW||Proceedings of the National Academy of Sciences of the United States of America (96:5215)||1999|
CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells.
MA5-11532 was used in flow cytometry to determine the functional properties of CK beta-11/MIP-3 beta/ELC.
|Kim CH,Pelus LM,White JR,Applebaum E,Johanson K,Broxmeyer HE||Journal of immunology (Baltimore, Md. : 1950) (160:2418)||1998|
Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1.
MA5-11532 was used in flow cytometry, immunohistochemistry - frozen section, and immunoprecipitation to characterize the monoclonal antibody UCHL1.
|Smith SH,Brown MH,Rowe D,Callard RE,Beverley PC||Immunology (58:63)||1986|
A giant primary sclerosing lipogranuloma of the scrotum.
MA5-11532 was used in immunohistochemistry to report on a case of giant primary sclerosing lipogranuloma of the scrotum
|Mungan S,Karagüzel E,Turan C,Re¿s A||Turk patoloji dergisi (30:78)||2014|
Axonal projections of mechanoreceptive dorsal root ganglion neurons depend on Ret.
MA5-11532 was used in immunohistochemistry to study the role of Ret in the neurturin-mediated formation of precise axonal projections in the central nervous system
|Honma Y,Kawano M,Kohsaka S,Ogawa M||Development (Cambridge, England) (137:2319)||2010|
Hyperplasia of hair follicles and other adnexal structures in cutaneous lymphoproliferative disorders: a study of 53 cases, including so-called pseudolymphomatous folliculitis and overt lymphomas.
MA5-11532 was used in immunohistochemistry to study 53 cases of cutaneous lymphoproliferative disorders
|Kazakov DV,Belousova IE,Kacerovska D,Sima R,Vanecek T,Vazmitel M,Pizinger K,Michal M||The American journal of surgical pathology (32:1468)||2008|
A patient with clinicopathologic features of small plaque parapsoriasis presenting later with plaque-stage mycosis fungoides: report of a case and comparative retrospective study of 27 cases of "nonprogressive" small plaque parapsoriasis.
MA5-11532 was used in immunohistochemistry to report on a case of small plaque parapsoriasis with plaque-stage mycosis fungoides
|Belousova IE,Vanecek T,Samtsov AV,Michal M,Kazakov DV||Journal of the American Academy of Dermatology (59:474)||2008|
Primary cutaneous histiocyte and neutrophil-rich CD30+ and CD56+ anaplastic large-cell lymphoma with prominent angioinvasion and nerve involvement in the forehead and scalp of an immunocompetent woman.
MA5-11532 was used in immunohistochemistry to report on a case of utaneous lymphoma of the head co-expressing CD56 and CD30
|Boudova L,Kazakov DV,Jindra P,Sima R,Vanecek T,Kuntscher V,Vera V,Bouda J,Michal M||Journal of cutaneous pathology (33:584)||2006|
Cutaneous lymphoid hyperplasia and other lymphoid infiltrates of the breast nipple: a retrospective clinicopathologic study of fifty-six patients.
MA5-11532 was used in immunohistochemistry to study the clinicopathological spectrum of lymphoproliferations and other lymphoid infiltration of the breast nipple
|Boudova L,Kazakov DV,Sima R,Vanecek T,Torlakovic E,Lamovec J,Kutzner H,Szepe P,Plank L,Bouda J,Hes O,Mukensnabl P,Michal M||The American Journal of dermatopathology (27:375)||2005|
CIK cells from patients with HCC possess strong cytotoxicity to multidrug-resistant cell line Bel-7402/R.
MA5-11532 was used in immunohistochemistry to investigate the effectiveness of cytokine-induced killer cell treatment in patient with hepatocellular carcinoma
|Zhang YS,Yuan FJ,Jia GF,Zhang JF,Hu LY,Huang L,Wang J,Dai ZQ||World journal of gastroenterology (11:3339)||2005|
T-cell-rich B-cell lymphoma: a clinicopathologic study of 21 cases and comparison with 43 cases of diffuse large B-cell lymphoma.
MA5-11532 was used in immunohistochemistry to compare the clinocopathology of T-cell rich B-cell lymphoma and diffuse large B-cell lymphoma
|Aki H,Tuzuner N,Ongoren S,Baslar Z,Soysal T,Ferhanoglu B,Sahinler I,Aydin Y,Ulku B,Aktuglu G||Leukemia research (28:229)||2004|
|Not Applicable||Not Cited||
Effector Memory T cells Are Associated With Atherosclerosis in Humans and Animal Models.
MA5-11532 was used in flow cytometry to study the relationship between circulating CD4+ T-cell subsets and atherosclerosis
|Ammirati E,Cianflone D,Vecchio V,Banfi M,Vermi AC,De Metrio M,Grigore L,Pellegatta F,Pirillo A,Garlaschelli K,Manfredi AA,Catapano AL,Maseri A,Palini AG,Norata GD||Journal of the American Heart Association (1:27)||2012|
|Not Applicable||Not Cited||
Natural regulatory T cells: number and function are normal in the majority of patients with lupus nephritis.
MA5-11532 was used in flow cytometry to examine the frequency, phenotype, and function of T regulatory cells in patients with systemic lupus erythematosus and inactive disease
|Yates J,Whittington A,Mitchell P,Lechler RI,Lightstone L,Lombardi G||Clinical and experimental immunology (153:44)||2008|
|Not Applicable||Not Cited||
Monocyte-derived human macrophages mediate anergy in allogeneic T cells and induce regulatory T cells.
MA5-11532 was used in flow cytometry to assess the T cell-stimulatory capacity of mature dendritic cells and macrophages using a model of allogeneic MLR
|Hoves S,Krause SW,Schütz C,Halbritter D,Schölmerich J,Herfarth H,Fleck M||Journal of immunology (Baltimore, Md. : 1950) (177:2691)||2006|
Up-regulation of expression of the ubiquitin carboxyl-terminal hydrolase L1 gene in human airway epithelium of cigarette smokers.
MA5-11532 was used in immunocytochemistry to investigate the expression of carboxyl-terminal hydrolyase L1 gene in human airway epithelium of cigarette smokers
|Carolan BJ,Heguy A,Harvey BG,Leopold PL,Ferris B,Crystal RG||Cancer research (66:10729)||2006|
B220; CD45; CD45 antigen; CD45R; GP180; L-CA; LCA; leucocyte common antigen; Leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; LY5; lymphocyte antigen 5; lymphocyte common antigen; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; Protein tyrosine phosphatase, receptor-type, c polypeptide; Receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein; T200 leukocyte common antigen
B220; CD45; CD45R; GP180; L-CA; LCA; loc; Ly-5; LY5; Lyt-4; PTPRC; RT7; T200