|Tested species reactivity||Human|
|Published species reactivity||Human, Mouse, Not Applicable|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Human IL-2 dependent T cells.|
|Storage buffer||PBS, pH 7.4|
|Contains||15mM sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||10ul x 100ul whole blood or 10^6 cells|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Pretreatment note: MA1-19452 does not require protein digestion pretreatment of paraffin sections and does not require antigen retrieval using heat treatment prior to staining of paraffin sections. A suggested positive control for this product is tonsil tissue.
CD45R0 is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45R0 is expressed e.g. on macrophages, CD8+ T cells, activated T cells and myeloma cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CD30(+) extranodal natural killer/T-cell lymphoma mimicking phlegmonous myositis: A case report.
MA1-19452 was used in immunohistochemistry (paraffin) to report on a case of CD30-positive extranodal natural killer/T-cell lymphoma.
|Yang YJ,Li YX,Liu YB,Yang M,Liu K||Oncology letters (7:1419)||2014|
Serous effusion cytology of extranodal natural killer/T-cell lymphoma.
MA1-19452 was used in flow cytometry to characterize extranodal natural killer/T-cell lymphoma, nasal type using patient samples.
|Su XY,Huang J,Jiang Y,Tang Y,Li GD,Liu WP||Cytopathology : official journal of the British Society for Clinical Cytology (23:96)||2012|
The significance of multiplex PCR/heteroduplex analysis-based TCR-¿ gene rearrangement combined with laser-capture microdissection in the diagnosis of early mycosis fungoides.
MA1-19452 was used in immunohistochemistry (paraffin) to study the diagnostic value for detecting early mycosis fungoides of a combination of multiplex PCR analyis of TCRgamma gene rearrangements and laser-capture microdissection.
|Yang H,Xu C,Tang Y,Wan C,Liu W,Wang L||Journal of cutaneous pathology (39:337)||2012|
IL-21 can supplement suboptimal Lck-independent MAPK activation in a STAT-3-dependent manner in human CD8(+) T cells.
MA1-19452 was used in flow cytometry to investigate the role of CD8 and antigen in proliferation of CTLs.
|Imataki O,Ansén S,Tanaka M,Butler MO,Berezovskaya A,Milstein MI,Kuzushima K,Nadler LM,Hirano N||Journal of immunology (Baltimore, Md. : 1950) (188:1609)||2012|
Chemokine receptor CCR4 on CD4+ T cells in juvenile rheumatoid arthritis synovial fluid defines a subset of cells with increased IL-4:IFN-gamma mRNA ratios.
MA1-19452 was used in flow cytometry to elucidate the mechanisms that promote recruitment and survival of T cells within the pediatric inflamed joint.
|Thompson SD,Luyrink LK,Graham TB,Tsoras M,Ryan M,Passo MH,Glass DN||Journal of immunology (Baltimore, Md. : 1950) (166:6899)||2001|
Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages.
MA1-19452 was used in flow cytometry to determine the number of CD4, CCR5, and CXCR4 antibody-binding sites on various T cells and macrophages.
|Lee B,Sharron M,Montaner LJ,Weissman D,Doms RW||Proceedings of the National Academy of Sciences of the United States of America (96:5215)||1999|
CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells.
MA1-19452 was used in flow cytometry to determine the functional properties of CK beta-11/MIP-3 beta/ELC.
|Kim CH,Pelus LM,White JR,Applebaum E,Johanson K,Broxmeyer HE||Journal of immunology (Baltimore, Md. : 1950) (160:2418)||1998|
Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1.
MA1-19452 was used in flow cytometry, immunohistochemistry - frozen section, and immunoprecipitation to characterize the monoclonal antibody UCHL1.
|Smith SH,Brown MH,Rowe D,Callard RE,Beverley PC||Immunology (58:63)||1986|
A giant primary sclerosing lipogranuloma of the scrotum.
MA1-19452 was used in immunohistochemistry to report on a case of giant primary sclerosing lipogranuloma of the scrotum
|Mungan S,Karagüzel E,Turan C,Re¿s A||Turk patoloji dergisi (30:78)||2014|
Axonal projections of mechanoreceptive dorsal root ganglion neurons depend on Ret.
MA1-19452 was used in immunohistochemistry to study the role of Ret in the neurturin-mediated formation of precise axonal projections in the central nervous system
|Honma Y,Kawano M,Kohsaka S,Ogawa M||Development (Cambridge, England) (137:2319)||2010|
Hyperplasia of hair follicles and other adnexal structures in cutaneous lymphoproliferative disorders: a study of 53 cases, including so-called pseudolymphomatous folliculitis and overt lymphomas.
MA1-19452 was used in immunohistochemistry to study 53 cases of cutaneous lymphoproliferative disorders
|Kazakov DV,Belousova IE,Kacerovska D,Sima R,Vanecek T,Vazmitel M,Pizinger K,Michal M||The American journal of surgical pathology (32:1468)||2008|
A patient with clinicopathologic features of small plaque parapsoriasis presenting later with plaque-stage mycosis fungoides: report of a case and comparative retrospective study of 27 cases of "nonprogressive" small plaque parapsoriasis.
MA1-19452 was used in immunohistochemistry to report on a case of small plaque parapsoriasis with plaque-stage mycosis fungoides
|Belousova IE,Vanecek T,Samtsov AV,Michal M,Kazakov DV||Journal of the American Academy of Dermatology (59:474)||2008|
Primary cutaneous histiocyte and neutrophil-rich CD30+ and CD56+ anaplastic large-cell lymphoma with prominent angioinvasion and nerve involvement in the forehead and scalp of an immunocompetent woman.
MA1-19452 was used in immunohistochemistry to report on a case of utaneous lymphoma of the head co-expressing CD56 and CD30
|Boudova L,Kazakov DV,Jindra P,Sima R,Vanecek T,Kuntscher V,Vera V,Bouda J,Michal M||Journal of cutaneous pathology (33:584)||2006|
Cutaneous lymphoid hyperplasia and other lymphoid infiltrates of the breast nipple: a retrospective clinicopathologic study of fifty-six patients.
MA1-19452 was used in immunohistochemistry to study the clinicopathological spectrum of lymphoproliferations and other lymphoid infiltration of the breast nipple
|Boudova L,Kazakov DV,Sima R,Vanecek T,Torlakovic E,Lamovec J,Kutzner H,Szepe P,Plank L,Bouda J,Hes O,Mukensnabl P,Michal M||The American Journal of dermatopathology (27:375)||2005|
CIK cells from patients with HCC possess strong cytotoxicity to multidrug-resistant cell line Bel-7402/R.
MA1-19452 was used in immunohistochemistry to investigate the effectiveness of cytokine-induced killer cell treatment in patient with hepatocellular carcinoma
|Zhang YS,Yuan FJ,Jia GF,Zhang JF,Hu LY,Huang L,Wang J,Dai ZQ||World journal of gastroenterology (11:3339)||2005|
T-cell-rich B-cell lymphoma: a clinicopathologic study of 21 cases and comparison with 43 cases of diffuse large B-cell lymphoma.
MA1-19452 was used in immunohistochemistry to compare the clinocopathology of T-cell rich B-cell lymphoma and diffuse large B-cell lymphoma
|Aki H,Tuzuner N,Ongoren S,Baslar Z,Soysal T,Ferhanoglu B,Sahinler I,Aydin Y,Ulku B,Aktuglu G||Leukemia research (28:229)||2004|
|Not Applicable||Not Cited||
Effector Memory T cells Are Associated With Atherosclerosis in Humans and Animal Models.
MA1-19452 was used in flow cytometry to study the relationship between circulating CD4+ T-cell subsets and atherosclerosis
|Ammirati E,Cianflone D,Vecchio V,Banfi M,Vermi AC,De Metrio M,Grigore L,Pellegatta F,Pirillo A,Garlaschelli K,Manfredi AA,Catapano AL,Maseri A,Palini AG,Norata GD||Journal of the American Heart Association (1:27)||2012|
|Not Applicable||Not Cited||
Natural regulatory T cells: number and function are normal in the majority of patients with lupus nephritis.
MA1-19452 was used in flow cytometry to examine the frequency, phenotype, and function of T regulatory cells in patients with systemic lupus erythematosus and inactive disease
|Yates J,Whittington A,Mitchell P,Lechler RI,Lightstone L,Lombardi G||Clinical and experimental immunology (153:44)||2008|
|Not Applicable||Not Cited||
Monocyte-derived human macrophages mediate anergy in allogeneic T cells and induce regulatory T cells.
MA1-19452 was used in flow cytometry to assess the T cell-stimulatory capacity of mature dendritic cells and macrophages using a model of allogeneic MLR
|Hoves S,Krause SW,Schütz C,Halbritter D,Schölmerich J,Herfarth H,Fleck M||Journal of immunology (Baltimore, Md. : 1950) (177:2691)||2006|
Up-regulation of expression of the ubiquitin carboxyl-terminal hydrolase L1 gene in human airway epithelium of cigarette smokers.
MA1-19452 was used in immunocytochemistry to investigate the expression of carboxyl-terminal hydrolyase L1 gene in human airway epithelium of cigarette smokers
|Carolan BJ,Heguy A,Harvey BG,Leopold PL,Ferris B,Crystal RG||Cancer research (66:10729)||2006|