CD48 (Blast-1) belongs to the CD2 subset of the Ig superfamily, which includes CD2, CD2F-10, CD58, CD84, CD150, CD229, CD244 and others. These molecules bind to the same or another members of their family, thus mediate homotypic or heterotypic adhesion. CD48 is a GPI-anchored protein broadly expressed on hematopoietic cells and serves as a high affinity ligand for 2B4 and low affinity ligand for CD2. 2B4-CD48 interaction among NK cells and NK-T cells regulates cell proliferation. Signaling through CD48 results in eosinophil activation and CD48 expression is increased in several infectious diseases.
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Protein Aliases: BCM1; BCM1 surface antigen; BLAST; BLAST1; CD48 antigen; hCD48; HM48-1; mCD48; MEM-102; MRC OX-45 surface antigen; signaling lymphocytic activation molecule 2; SLAM family member 2; SLAMF2
Gene Aliases: AI449234; AW610730; Bcm-1; BCM1; BLAST; BLAST-1; BLAST1; MEM-102; Sgp-60; SLAMF2
UniProt ID: (Mouse) P18181
Entrez Gene ID: (Mouse) 12506