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Invitrogen
CD49a (Integrin alpha 1) Recombinant Rabbit Monoclonal Antibody (7T5B6)
FIGURE: 1 / 1
CD49a (Integrin alpha 1) Antibody (MA5-55280) in WB
Western Blot analysis of various lysates using CD49a (Integrin alpha 1) Recombinant Monoclonal Antibody (Product # MA5-55280) at 1:10,0000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) at 1:10,000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
Product Details
MA5-55280
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
7T5B6
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 29-1141 of human Integrin alpha 1 (ITGA1/CD49a).
Conjugate
Form
Liquid
Concentration
0.72 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
RRID
AB_3667522
Product Specific Information
Immunogen Sequence: FNVDVKNSMT FSGPVEDMFG YTVQQYENEE GKWVLIGSPL VGQPKNRTGD VYKCPVGRGE SLPCVKLDLP VNTSIPNVTE VKENMTFGST LVTNPNGGFL ACGPLYAYRC GHLHYTTGIC SDVSPTFQVV NSIAPVQECS TQLDIVIVLD GSNSIYPWDS VTAFLNDLLE RMDIGPKQTQ VGIVQYGENV THEFNLNKYS STEEVLVAAK KIVQRGGRQT MTALGIDTAR KEAFTEARGA RRGVKKVMVI VTDGESHDNH RLKKVIQDCE DENIQRFSIA ILGSYNRGNL STEKFVEEIK SIASEPTEKH FFNVSDELAL VTIVKTLGER IFALEATADQ SAASFEMEMS QTGFSAHYSQ DWVMLGAVGA YDWNGTVVMQ KASQIIIPRN TTFNVESTKK NEPLASYLGY TVNSATASSG DVLYIAGQPR YNHTGQVIIY RMEDGNIKIL QTLSGEQIGS YFGSILTTTD IDKDSNTDIL LVGAPMYMGT EKEEQGKVYV YALNQTRFEY QMSLEPIKQT CCSSRQHNSC TTENKNEPCG ARFGTAIAAV KDLNLDGFND IVIGAPLEDD HGGAVYIYHG SGKTIRKEYA QRIPSGGDGK TLKFFGQSIH GEMDLNGDGL TDVTIGGLGG AALFWSRDVA VVKVTMNFEP NKVNIQKKNC HMEGKETVCI NATVCFDVKL KSKEDTIYEA DLQYRVTLDS LRQISRSFFS GTQERKVQRN ITVRKSECTK HSFYMLDKHD FQDSVRITLD FNLTDPENGP VLDDSLPNSV HEYIPFAKDC GNKEKCISDL SLHVATTEKD LLIVRSQNDK FNVSLTVKNT KDSAYNTRTI VHYSPNLVFS GIEAIQKDSC ESNHNITCKV GYPFLRRGEM VTFKILFQFN TSYLMENVTI YLSATSDSEE PPETLSDNVV NISIPVKYEV GLQFYSSASE YHISIAANET VPEVINSTED IGNEINIFYL IRKSGSFPMP ELKLSISFPN MTSNGYPVLY PTGLSSSENA NCRPHIFEDP FSINSGKKMT TSTDHLKRGT ILDCNTCKFA TITCNLTSSD ISQVNVSLIL WKPTFIKSYF SSLNLTIRGE LRSENASLVL SSSNQKRELA IQISKDGLPG RVP
Target Information
Integrin alpha 1 (ITGA1) chain associates with the beta 1 (ITGB1) chain to form a heterodimer that functions as a dual laminin/collagen receptor in neural cells and hematopoietic cells. ITGA1 has a 206-amino acid I domain in its N-terminal half, followed by 3 divalent cation-binding sites and a C-terminal transmembrane domain with a short cytoplasmic tail. It also has 28 potential N-glycosylation sites. Human ITGA1 was expressed in a mouse fibroblast cell line as a 180-kD protein. ITGA1 is involved in the early remodeling of osteoarthritic cartilage and plays an essential role in the regulation of mesenchymal stem cell proliferation and cartilage production. It also plays an essential role in the regulation of MSC proliferation and cartilage production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD49 antigen-like family member A; CD49a; integrin alpha 1; Integrin alpha-1; integrin, alpha 1; Laminin and collagen receptor; very late activation protein 1; VLA-1
Gene Aliases: CD49a; ITGA1; VLA1
UniProt ID: (Human) P56199
Entrez Gene ID: (Human) 3672
activation of MAPK activity
muscle contraction
cell-matrix adhesion
integrin-mediated signaling pathway
negative regulation of cell proliferation
extracellular matrix organization
neutrophil chemotaxis
positive regulation of phosphoprotein phosphatase activity
negative regulation of epidermal growth factor receptor signaling pathway
vasodilation
positive regulation of neuron apoptotic process
cellular extravasation
neuron projection morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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