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Invitrogen
CD49a (Integrin alpha 1) Monoclonal Antibody (TS2/7)
FIGURE: 1 / 1
CD49a (Integrin alpha 1) Antibody (MA5-44044) in Flow
Separation of HeLa cells stained using anti-CD49a (TS2/7) purified Monoclonal antibody (Product # MA5-44044), concentration in sample 0.6 µg/mL, GAM APC (red-filled) from HeLa cells unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining).
Product Details
MA5-44044
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
TS2/7
Immunogen
human CTL line
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4° C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2912976
Product Specific Information
This antibody recognizes an extracellular epitope of CD49a, the alpha 1 chain of VLA integrin complex, that serves as an adhesion receptor for collagen IV and laminin 1.
Target Information
Integrin alpha 1 (ITGA1) chain associates with the beta 1 (ITGB1) chain to form a heterodimer that functions as a dual laminin/collagen receptor in neural cells and hematopoietic cells. ITGA1 has a 206-amino acid I domain in its N-terminal half, followed by 3 divalent cation-binding sites and a C-terminal transmembrane domain with a short cytoplasmic tail. It also has 28 potential N-glycosylation sites. Human ITGA1 was expressed in a mouse fibroblast cell line as a 180-kD protein. ITGA1 is involved in the early remodeling of osteoarthritic cartilage and plays an essential role in the regulation of mesenchymal stem cell proliferation and cartilage production. It also plays an essential role in the regulation of MSC proliferation and cartilage production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD49 antigen-like family member A; CD49a; integrin alpha 1; Integrin alpha-1; integrin, alpha 1; Laminin and collagen receptor; very late activation protein 1; VLA-1
Gene Aliases: CD49a; ITGA1; VLA1
UniProt ID: (Human) P56199
Entrez Gene ID: (Human) 3672
activation of MAPK activity
muscle contraction
cell-matrix adhesion
integrin-mediated signaling pathway
negative regulation of cell proliferation
extracellular matrix organization
neutrophil chemotaxis
positive regulation of phosphoprotein phosphatase activity
negative regulation of epidermal growth factor receptor signaling pathway
vasodilation
positive regulation of neuron apoptotic process
cellular extravasation
neuron projection morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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