Invitrogen

CD49b (Integrin alpha 2) Monoclonal Antibody (AK7), FITC

Product Image Gallery

CD49b (Integrin alpha 2) Antibody in Flow Cytometry (Flow) — Flow cytometry of CD49b (Integrin alpha 2) in lymphocytes (red-filled) and CD49b negative lymphocytes (black-dashed). Samples were incubated with CD49b (Integrin alpha 2) monoclonal antibody (Product # MA5-38698) followed by FITC at a dilution of 4 µL reagent/100 µL of peripheral whole blood.

Product Details

MA5-38698

Applications	Tested Dilution	Publications
Flow Cytometry (Flow)	10 µL/10^6 cells	-

Product Specifications
Species Reactivity	Human, Non-human primate
Host/Isotype	Mouse / IgG1
Class	Monoclonal
Type	Antibody
Clone	AK7
Immunogen	Human platelets
Conjugate	FITC PE Unconjugated
Excitation/Emission Profile	View spectra
Form	Liquid
Concentration	0.08 mg/mL
Purification	Size-exclusion chromatography
Storage buffer	PBS with 0.2% BSA
Contains	15mM sodium azide
Storage conditions	4° C, store in dark, DO NOT FREEZE!

Product Specific Information

Do not use after expiration date stamped on vial label.

Target Information

CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family. It is a glycoprotein with molecular weight of 150 kD, and it complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex. VLA-2 is an extracellular receptor for laminin, collagen, and fibronectin, and interaction with its ligands results in the activation of intracellular signaling pathways. It has reported roles in VEGF-induced angiogenesis in vivo, as well as adhesion and lymphocyte activation. CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, and epithelial cells. It is also expressed on adaptive immune cells such as T and B cells, specifically on a subset of CD4+ T cells in the spleen, on intraepithelial and lamina propria lymphocytes in the intestine, as well as on a population of peripheral CD4+ type 1 T regulatory (Tr1) cells that co-express LAG-3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Flow Cytometry

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Bioinformatics

Protein Aliases: alpha 2 subunit of VLA-2 receptor; BDPLT9; CD49 antigen-like family member B; CD49b; Collagen receptor; GPIa; human platelet alloantigen system 5; Integrin alpha-2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); platelet antigen Br; platelet glycoprotein GPIa; Platelet membrane glycoprotein Ia; very late activation protein 2 receptor, alpha-2 subunit; VLA-2 subunit alpha; VLA2 receptor

Gene Aliases: BR; CD49B; GPIa; HPA-5; ITGA2; VLA-2; VLAA2

UniProt ID: (Human) P17301

Entrez Gene ID: (Human) 3673

Molecular Function: integrin