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|Tested species reactivity||Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||C3H.CE - Ly 1.2 : DS|
|Storage buffer||PBS with 4-5mg/ml BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||0.1 ug/10^6 cells|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Miscellaneous PubMed (MISC)||See 2 publications below|
MA5-17786 targets CD5/Ly-1 in FACS applications and shows reactivity with Mouse samples.
The MA5-17786 immunogen is c3H.CE - Ly 1.2 : DS.
The CD5, a transmembrane protein, is found on 95%of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas, and activated T cells. Occasionally, CD5 antigen is also expressed on a subset of B cells. Mantle cell lymphomas (same as diffuse centrocytic lymphomas) are CD5+ while the follicle center cell lymphoma are CD5-.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Resting memory CD8+ T cells are hyperreactive to antigenic challenge in vitro.
MA5-17786 was used in flow cytometry to test if different activation thresholds distinguish naive from memory CD8+ T cell populations.
|Pihlgren M,Dubois PM,Tomkowiak M,Sjögren T,Marvel J||The Journal of experimental medicine (184:2141)||1996|
The role of peritoneal stromal cells in the survival of sIgM+ peritoneal B lymphocyte populations.
MA5-17786 was used in flow cytometry to determine if the unusual growth and survival of peritoneal B1 cells is intrinsic or extrinsic.
|Hardin JA,Yamaguchi K,Sherr DH||Cellular immunology (161:50)||1995|
CD5; CD5 antigen p56-62; Ly-1; Lymphocyte antigen 1; lymphocyte antigen T1/Leu-1; T-cell surface glycoprotein CD5
Cd5; Ly-1; Ly-12; Ly-A; Lyt-1